The Effect of Transcranial Photobiomodulation for Motor Performance
Improvement in Patients with Brain Disorders

Milad      Iravani; Abbas   Ebrahimi   Kalan; Maryam   Moghaddam   Salimi; Ali      Jahan

doi:10.2174/0115743624250965231116060824

Abstract

Background: Transcranial photobiomodulation (PBM) therapy has emerged as a promising alternative therapeutic option for the management of neurological and psychiatric disorders. However, the underlying mechanisms of PBM therapy and its effects on motor performance in brain disorders are not yet fully understood. The aim of this literature review is to provide a more detailed and evidence-based explanation of the rationale and intent behind the correlation between PBM therapy and its effects on motor performance in brain disorders.

Methods: A literature search was performed in the databases "PubMed/Medline", "Scopus," and "Google Scholar" for all relevant English language papers. A combination of different keywords was used for the database search. Video articles, patents, review articles, book chapters, articles using other transcranial methods, non-transcranial PBM, and case reports were excluded.

Results: Out of the 2174 papers, 18 addressed the effect of PBM on motor performance. Among these, four studies were on ischemic stroke models and individuals with stroke, six studies on models associated with traumatic brain injury (TBI), five studies on models associated with neurodegenerative diseases and Parkinson's disease, and four studies related to models and patients with central nervous system inflammation. All studies have shown that motor parameters improve with PBM. In two studies on healthy individuals, 65 showed improvement in motor function and 16 showed improvement in motor evoked potential. In most studies (n=10), the wavelength used was between 800 and 900 nm. Near-infrared or LED continuous light was used in most studies. However, two studies compared the effects of pulsed and continuous waves and found the superiority of pulsed over continuous waves.

Conclusions: PBM therapy appears to be useful in brain injury, inducing changes at the behavioral, motor, cellular, and chemical levels. Recent studies suggest that PBM therapy may have potential benefits in improving motor performance in brain disorders, including stroke, traumatic brain injury, Parkinson's disease, and demyelination. However, further research is needed to determine the optimal parameters for PBM therapy and to investigate its effects on motor function in different brain disorders. Overall, PBM therapy appears to be a promising therapeutic option for brain injury and warrants further investigation.

Keywords: Low-level light therapy, transcranial photobiomodulation, motor, near-infrared, brain disorders, neurological and psychiatric disorders.

Graphical Abstract

[1]
Feigin VL, Vos T, Nichols E, et al. Global burden of neurological disorders: Estimates and projections. Neurol Res  2021; 43(4): 266-71.

[2]
Feigin VL, Nichols E, Alam T, et al. Global, regional, and national burden of neurological disorders, 1990–2016: A systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol  2019; 18(5): 459-80.
 [http://dx.doi.org/10.1016/S1474-4422(18)30499-X] [PMID: 30879893]

[3]
Stevens AR, Hadis M, Milward M, et al. Photobiomodulation Therapy for Traumatic Brain Injury: A Systematic Review and Meta-Analysis. J Neurotrauma  2023; 40(3-4): 210-27.
 [http://dx.doi.org/10.1089/neu.2022.0140]

[4]
Wu Q. The effects of photobiomodulation therapy on neurological function recovery in patients with traumatic brain injury: A systematic review and meta-analysis. Brain Inj  2021; 35(3): 224-38.
 [http://dx.doi.org/10.1080/02699052.2020.1874310]

[5]
Chung H, Dai T, Sharma SK, Huang YY, Carroll JD, Hamblin MR. The nuts and bolts of low-level laser (light) therapy. Ann Biomed Eng  2012; 40(2): 516-33.
 [http://dx.doi.org/10.1007/s10439-011-0454-7] [PMID: 22045511]

[6]
Guo S, Wang R, Hu J. Photobiomodulation Promotes Hippocampal CA1 NSC Differentiation Toward Neurons and Facilitates Cognitive Function Recovery Involving NLRP3 Inflammasome Mitigation Following Global Cerebral Ischemia. Front Cell Neurosci  2021; 15: 731855.
 [http://dx.doi.org/10.3389/fncel.2021.731855] [PMID: 34489645]

[7]
Salehpour F. Photobiomodulation for cognitive enhancement and brain neuroprotection. J Photochem Photobiol B  2020; 202: 111684.
 [http://dx.doi.org/10.1016/j.jphotobiol.2019.111684]

[8]
Zhang Q. Photobiomodulation Therapy for Cognitive Impairment and Neuroinflammation in Neurological and Neuropsychiatric Disorders: A Systematic Review. Front Neurosci  2020; 14: 596699.
 [http://dx.doi.org/10.3389/fnins.2020.596699]

[9]
Salehpour F. Near-infrared photobiomodulation in healthy volunteers: A randomized, placebo-controlled, double-blind, crossover study. Brain Stimul  2018; 11(6): 1290-9.

[10]
Salehpour F. Photobiomodulation therapy improves cognitive function and increases cerebral blood flow in patients with mild cognitive impairment: A randomized controlled trial. Photobiomodul Photomed Laser Surg  2021; 39(10): 687-95.
 [http://dx.doi.org/10.1089/photob.2021.0003]

[11]
Almasi S. Effects of photobiomodulation therapy on cognitive function, depression, and anxiety in individuals with multiple sclerosis: A randomized double-blind controlled trial. Lasers Med Sci  2022; 37(2): 381-8.
 [http://dx.doi.org/10.1007/s10103-021-03436-1]

[12]
Quirk BJ. Review of transcranial photobiomodulation for major depressive disorder: Targeting brain metabolism, inflammation, oxidative stress, and neurogenesis. Neurophotonics  2019; 6(4): 041408.

[13]
Zhou J. Photobiomodulation promotes synaptogenesis and neurogenesis through nerve growth factor signaling pathway after cerebral ischemia-reperfusion injury. Brain Res  2021; 1762: 147462.
 [http://dx.doi.org/10.1016/j.brainres.2021.147462]

[14]
Campbell BCV, Mitchell PJ, Churilov L, et al. Tenecteplase versus alteplase before thrombectomy for ischemic stroke. N Engl J Med  2018; 378(17): 1573-82.
 [http://dx.doi.org/10.1056/NEJMoa1716405] [PMID: 29694815]

[15]
Mokhtarzadeh A. Photobiomodulation therapy improves neurological function and decreases oxidative stress markers in a rat model of traumatic brain injury. Lasers Med Sci  2022; 37(5): 1359-66.

[16]
Moriyama Y, Aizawa K, Izu Y, Takemura M, Tanaka Y, Toda T. Transcranial low-level laser therapy improves neurological performance in mice with induced multiple sclerosis. Lasers Med Sci  2020; 35(4): 941-8.

[17]
Ferraresi C, de Brito Vieira WH, Perez SEA, Baldissera V, Parizotto NA, Marcos RL. Effects of low-level laser therapy (LLLT) in the development of exercise-induced skeletal muscle fatigue and changes in biochemical markers related to postexercise recovery: A systematic review. J Orthop Sports Phys Ther  2018; 48(11): 887-903.
 [PMID: 29895236]

[18]
Baroni BM, Leal-Junior EC, Geremia JM, Dornelles MP. Photobiomodulation therapy for the improvement of peripheral nerve regeneration: A systematic review and meta-analysis. Lasers Med Sci  2020; 35(4): 853-67.
 [PMID: 31486933]

[19]
Zhang Z. Non-invasive transcranial infrared laser therapy for Alzheimer’s disease: A randomized, placebo-controlled trial. Alzheimers Res Ther  2017; 9(1): 25.
 [http://dx.doi.org/10.1186/s13195-017-0246-9] [PMID: 28359327]

[20]
Naeser MA, Zafonte R, Krengel MH, et al. Significant improvements in cognitive performance post-transcranial, red/near-infrared light-emitting diode treatments in chronic, mild traumatic brain injury: Open-protocol study. J Neurotrauma  2014; 31(11): 1008-17.
 [http://dx.doi.org/10.1089/neu.2013.3244] [PMID: 24568233]

[21]
Brunoni AR. Transcranial direct current stimulation: Challenges, opportunities, and impact on psychiatry and neurorehabilitation. Front Psychiatry  2021; 12: 707734.
 [PMID: 23544030]

[22]
Huang YZ. Clinical neurophysiology of transcranial magnetic stimulation. Clin Neurophysiol  2017; 128(9): 1719-40.
 [PMID: 28756348]

[23]
Johnstone DM. Turning on lights to stop neurodegeneration: The potential of near infrared light therapy in Alzheimer’s and Parkinson’s disease. Front Neurosci  2021; 15: 672116.
 [http://dx.doi.org/10.3389/fnins.2021.672116] [PMID: 26793049]

[24]
Salehpour F. Photobiomodulation therapy and its effects on motor symptoms of Parkinson’s disease: A systematic review and meta-analysis. Lasers Med Sci  2021; 36(8): 1431-43.

[25]
Hamblin MR. Photobiomodulation for traumatic brain injury and stroke. J Neurosci Res  2018; 96(4): 731-43.
 [http://dx.doi.org/10.1002/jnr.24190] [PMID: 29131369]

[26]
Salehpour F, Mahmoudi J, Kamari F, Sadigh-Eteghad S, Rasta SH. Transcranial photobiomodulation prevents anxiety and depression via changing serotonin and nitric oxide levels in brain of depression model mice: A study of three different doses of 810 nm laser. Lasers Med Sci  2018; 33(6): 1395-403.

[27]
Salehpour F, Farhoudi M, Mahmoudi J. Therapeutic effects of transcranial photobiomodulation on cognitive impairment in neurodegenerative diseases. J Lasers Med Sci  2019; 10(2): 158-64.

[28]
R Hamblin M. Huang YY, Sharma SK, Carroll JD, de Sousa MV. Mechanisms and applications of the anti-inflammatory effects of photobiomodulation. AIMS Biophys  2017; 4(3): 337-61.
 [http://dx.doi.org/10.3934/biophy.2017.3.337] [PMID: 28748217]

[29]
Salehpour F, Mahmoudi J, Kamari F, Sadigh-Eteghad S, Rasta SH. Transcranial photobiomodulation improves cognitive function in healthy individuals: A randomized, double-blind, placebo-controlled study. Photobiomodul Photomed Laser Surg  2021; 39(3): 189-96.

[30]
Chao LL, Barlow C, Karimpoor M, Lim L. Changes in Brain Function and Structure After Self-Administered Home Photobiomodulation Treatment in a Concussion Case. Front Neurol  2020; 11: 952.
 [http://dx.doi.org/10.3389/fneur.2020.00952] [PMID: 33013635]

[31]
Fekri A, Jahan A, Moghadam Salimi M, Oskouei AE. Short-term Effects of Transcranial Near-Infrared Photobiomodulation on Motor Performance in Healthy Human Subjects: An Experimental SingleBlind Randomized Clinical Trial. J Lasers Med Sci  2019; 10(4): 317-23.
 [http://dx.doi.org/10.15171/jlms.2019.51] [PMID: 31875125]

[32]
Argibay B, Campos F, Perez-Mato M, et al. Light-Emitting Diode Photobiomodulation After Cerebral Ischemia. Front Neurol  2019; 10: 911.
 [http://dx.doi.org/10.3389/fneur.2019.00911] [PMID: 31507516]

[33]
Naeser MA, Ho MD, Martin PI, Hamblin MR, Koo BB. Increased Functional Connectivity Within Intrinsic Neural Networks in Chronic Stroke Following Treatment with Red/Near-Infrared Transcranial Photobiomodulation: Case Series with Improved Naming in Aphasia. Photobiomodul Photomed Laser Surg  2020; 38(2): 115-31.
 [http://dx.doi.org/10.1089/photob.2019.4630] [PMID: 31621498]

[34]
Meynaghizadeh-Zargar R, Sadigh-Eteghad S, Mohaddes G, Salehpour F, Rasta SH. Effects of transcranial photobiomodulation and methylene blue on biochemical and behavioral profiles in mice stress model. Lasers Med Sci  2020; 35(3): 573-84.
 [http://dx.doi.org/10.1007/s10103-019-02851-z] [PMID: 31372913]

[35]
Song P, Li S, Hao W, et al. Corticospinal excitability enhancement with simultaneous transcranial near-infrared stimulation and anodal direct current stimulation of motor cortex. Clin Neurophysiol  2021; 132(5): 1018-24.
 [http://dx.doi.org/10.1016/j.clinph.2021.01.020] [PMID: 33743296]

[36]
Song P, Han T, Lin H, et al. Transcranial near-infrared stimulation may increase cortical excitability recorded in humans. Brain Res Bull  2020; 155: 155-8.
 [http://dx.doi.org/10.1016/j.brainresbull.2019.12.007] [PMID: 31837460]

[37]
Ghaderi AH, Jahan A, Akrami F, Moghadam Salimi M. Transcranial photobiomodulation changes topology, synchronizability, and complexity of resting state brain networks. J Neural Eng  2021; 18(4): 046048.
 [http://dx.doi.org/10.1088/1741-2552/abf97c] [PMID: 33873167]

[38]
Jahan A, Nazari MA, Mahmoudi J, Salehpour F, Salimi MM. Transcranial near-infrared photobiomodulation could modulate brain electrophysiological features and attentional performance in healthy young adults. Lasers Med Sci  2019; 34(6): 1193-200.
 [http://dx.doi.org/10.1007/s10103-018-02710-3] [PMID: 31011865]

[39]
Bullock-Saxton J, Lehn A, Laakso EL. Exploring the Effect of Combined Transcranial and Intra-Oral Photobiomodulation Therapy Over a Four-Week Period on Physical and Cognitive Outcome Measures for People with Parkinson’s Disease: A Randomized Double-Blind Placebo-Controlled Pilot Study. J Alzheimers Dis  2021; 83(4): 1499-512.
 [http://dx.doi.org/10.3233/JAD-210170] [PMID: 34092640]

[40]
Oron A, Oron U, Streeter J, et al. Near infrared transcranial laser therapy applied at various modes to mice following traumatic brain injury significantly reduces long-term neurological deficits. J Neurotrauma  2012; 29(2): 401-7.
 [http://dx.doi.org/10.1089/neu.2011.2062] [PMID: 22040267]

[41]
Thunshelle C, Hamblin MR. Transcranial Low-Level Laser (Light) Therapy for Brain Injury. Photomed Laser Surg  2016; 34(12): 587-98.
 [http://dx.doi.org/10.1089/pho.2015.4051] [PMID: 28001759]

[42]
Duarte KCN, Soares TT, Magri AMP, et al. Low-level laser therapy modulates demyelination in mice. J Photochem Photobiol B  2018; 189: 55-65.
 [http://dx.doi.org/10.1016/j.jphotobiol.2018.09.024] [PMID: 30312921]

[43]
Ferraresi C, Huang YY, Hamblin MR. Photobiomodulation as a potential adjuvant therapy for periodontal disease. Front Oral Health  2021; 2: 604948.

[44]
Wang Y, Huang Z, Huang Y, et al. Transcranial photobiomodulation therapy improves cognitive function and modulates functional connectivity in patients with traumatic brain injury: A pilot study. Photomed Laser Surg  2020; 38(5): 273-81.
 [http://dx.doi.org/10.1089/pho.2019.4667]

[45]
Xu X, Liu H, Wang Y, et al. Transcranial photobiomodulation for motor function recovery after stroke: A randomized, double-blind, placebo-controlled trial. Photomedicine and Laser Surgery  2021; 39(5): 288-95.

[46]
Ferraresi C, Huang YY, Hamblin MR. Transient receptor potential vanilloid 1 (TRPV1) channels mediate the effects of 670 nm light emitting diode (LED) irradiation on thermal pain threshold and cerebral inflammation. BMC Neurosci  2021; 22(1): 27.

[47]
Lapchak PA, Salgado KF, Chao CH, Zivin JA. Transcranial near-infrared light therapy improves motor function following embolic strokes in rabbits: An extended therapeutic window study using continuous and pulse frequency delivery modes. Neuroscience  2007; 148(4): 907-14.
 [http://dx.doi.org/10.1016/j.neuroscience.2007.07.002] [PMID: 17693028]

[48]
Lee HI, Park JH, Park MY, et al. Pre-conditioning with transcranial low-level light therapy reduces neuroinflammation and protects blood-brain barrier after focal cerebral ischemia in mice. Restor Neurol Neurosci  2016; 34(2): 201-14.
 [http://dx.doi.org/10.3233/RNN-150559] [PMID: 26889965]

[49]
Ashrafi F, Rezaei A, Azhideh A, et al. Effectiveness of extremely low frequency electromagnetic field and pulsed low level laser therapy in acute stroke treatment. International Clinical Neuroscience Journal  2020; 7(3): 127-31.
 [http://dx.doi.org/10.34172/icnj.2020.13]

[50]
Xuan W, Vatansever F, Huang L, et al. Transcranial low-level laser therapy improves neurological performance in traumatic brain injury in mice: Effect of treatment repetition regimen. PLoS One  2013; 8(1): e53454.
 [http://dx.doi.org/10.1371/journal.pone.0053454] [PMID: 23308226]

[51]
Hesse S, Werner C, Byhahn M. Transcranial low-level laser therapy may improve alertness and awareness in traumatic brain injured subjects with severe disorders of consciousness: A case series. Int Arch Med  2015; 8.

[52]
Oron A, Oron U, Streeter J, et al. low-level laser therapy applied transcranially to mice following traumatic brain injury significantly reduces long-term neurological deficits. J Neurotrauma  2007; 24(4): 651-6.
 [http://dx.doi.org/10.1089/neu.2006.0198] [PMID: 17439348]

[53]
Oueslati A, Lovisa B, Perrin J, et al. Photobiomodulation suppresses alpha-synuclein-induced toxicity in an AAV-based rat genetic model of Parkinson’s disease. PLoS One  2015; 10(10): e0140880.
 [http://dx.doi.org/10.1371/journal.pone.0140880] [PMID: 26484876]

[54]
Moro C, Torres N, El Massri N, et al. Photobiomodulation preserves behaviour and midbrain dopaminergic cells from MPTP toxicity: Evidence from two mouse strains. BMC Neurosci  2013; 14(1): 40-0.
 [http://dx.doi.org/10.1186/1471-2202-14-40] [PMID: 23531041]

[55]
Liebert A, Bicknell B, Laakso EL, et al. Improvements in clinical signs of Parkinson’s disease using photobiomodulation: A prospective proof-of-concept study. BMC Neurol  2021; 21(1): 256.
 [http://dx.doi.org/10.1186/s12883-021-02248-y] [PMID: 34215216]

[56]
O’Brien JA, Austin PJ. Effect of Photobiomodulation in Rescuing Lipopolysaccharide-Induced Dopaminergic Cell Loss in the Male Sprague–Dawley Rat. Biomolecules  2019; 9(8): 381.
 [http://dx.doi.org/10.3390/biom9080381] [PMID: 31430990]

[57]
Maksimovich IV. Intracerebral Transcatheter Laser Photobiomodulation Therapy in the Treatment of Binswanger’s Disease and Vascular Parkinsonism: Research and Clinical Experience. Photobiomodul Photomed Laser Surg  2019; 37(10): 606-14.
 [http://dx.doi.org/10.1089/photob.2019.4649] [PMID: 31390288]

[58]
Bhattacharya M, Dutta A. Computational Modeling of the Photon Transport, Tissue Heating, and Cytochrome C Oxidase Absorption during Transcranial Near-Infrared Stimulation. Brain Sci  2019; 9(8): 179.
 [http://dx.doi.org/10.3390/brainsci9080179] [PMID: 31357574]

[59]
Huang YY, Gupta A, Vecchio D, de Arce VJB, Hamblin MR. Transcranial low-level laser therapy: A review of cognitive improvement and neuroprotection in animal models. Photobiomodul Photomed Laser Surg  2020; 38(10): 571-83.

[60]
Keshri GK, Gupta A, Yadav A, Hamblin MR. Photobiomodulation for traumatic brain injury and spinal cord injury: Mechanisms, applications, and future prospects. Semin Cell Dev Biol  2021; 112: 65-75.

[61]
Cardoso FS, Mansur FCB, Lopes-Martins RÁB, Gonzalez-Lima F, Gomes da Silva S. Transcranial Laser Photobiomodulation Improves Intracellular Signaling Linked to Cell Survival, Memory and Glucose Metabolism in the Aged Brain: A Preliminary Study. Front Cell Neurosci  2021; 15: 683127.
 [http://dx.doi.org/10.3389/fncel.2021.683127] [PMID: 34539346]

[62]
Esenaliev RO, Petrov IY, Petrov Y, et al. Nano-Pulsed Laser Therapy Is Neuroprotective in a Rat Model of Blast-Induced Neurotrauma. J Neurotrauma  2018; 35(13): 1510-22.
 [http://dx.doi.org/10.1089/neu.2017.5249] [PMID: 29562823]

[63]
Xuan W, Agrawal T, Huang L, Gupta GK, Hamblin MR. Low-level laser therapy for traumatic brain injury in mice increases brain derived neurotrophic factor (BDNF) and synaptogenesis. J Biophotonics  2015; 8(6): 502-11.
 [http://dx.doi.org/10.1002/jbio.201400069] [PMID: 25196192]

[64]
Mocciaro E, Grant A, Esenaliev RO, et al. Non-Invasive Transcranial Nano-Pulsed Laser Therapy Ameliorates Cognitive Function and Prevents Aberrant Migration of Neural Progenitor Cells in the Hippocampus of Rats Subjected to Traumatic Brain Injury. J Neurotrauma  2020; 37(8): 1108-23.
 [http://dx.doi.org/10.1089/neu.2019.6534] [PMID: 31856661]

[65]
Moreira MS, Velasco IT, Ferreira LS, et al. Effect of phototherapy with low intensity laser on local and systemic immunomodulation following focal brain damage in rat. J Photochem Photobiol B  2009; 97(3): 145-51.
 [http://dx.doi.org/10.1016/j.jphotobiol.2009.09.002] [PMID: 19800810]

[66]
Lei T, Lin J, Cheng B, Wang Z, He C, Li G. Photobiomodulation therapy attenuates neuroinflammation via modulating microglia polarization and inhibiting NF-κB signaling pathway in traumatic brain injury. J Neuroinflamm  2020; 18(1): 1-16.

[67]
Lanzafame RJ, Blanche RR, Chiacchierini RP, Kazmirek ER, Sklar JA. Photobiomodulation with Near-Infrared Light Helmet in a Pilot, Placebo-Controlled Clinical Trial in Dementia Patients with and without Stroke. Photobiomodul Photomed Laser Surg  2020; 38(10): 557-70.
 [http://dx.doi.org/10.1089/pho.2020.4852]

[68]
Lei H. Investigated the effects of photobiomodulation therapy on neuroinflammation and microglia polarization in traumatic brain injury. They found that PBM therapy reduced the expression of pro-inflammatory cytokines and chemokines, inhibited NF-κB signaling, and promoted the polarization of microglia towards an antiinflammatory phenotype. 2021; 25(12): 12-3.

[69]
Lanzafame. Conducted a pilot, placebo-controlled clinical trial to evaluate the effects of photobiomodulation therapy on dementia patients with and without stroke. They found that PBM therapy using a near-infrared light helmet improved cognitive function and reduced symptoms of depression in the patients. 2020; 32(12): 24-46.

[70]
Yang B, Xu J, Li Y, et al. Photobiomodulation therapy for repeated closed head injury in rats. J Biophotonics  2020; 13(2): e201960117.
 [http://dx.doi.org/10.1002/jbio.201960117] [PMID: 31657525]

[71]
Gerace E, Cialdai F, Sereni E, et al. NIR Laser Photobiomodulation Induces Neuroprotection in an in vitro Model of Cerebral Hypoxia/Ischemia. Mol Neurobiol  2021; 58(10): 5383-95.
 [http://dx.doi.org/10.1007/s12035-021-02496-6] [PMID: 34319540]

[72]
Khuman J, Zhang J, Park J, Carroll JD, Donahue C, Whalen MJ. Low-level laser light therapy improves cognitive deficits and inhibits microglial activation after controlled cortical impact in mice. J Neurotrauma  2012; 29(2): 408-17.
 [http://dx.doi.org/10.1089/neu.2010.1745] [PMID: 21851183]

[73]
Raza C, Anjum R, Shakeel N, Samoo Z, Riaz A, Jaffar A. Non-steroidal anti-inflammatory drugs as a potential treatment for Alzheimer’s disease: A review. AIMS Med Sci  2020; 7(3): 227-39.
 [http://dx.doi.org/10.3934/medsci.2020016]

[74]
Liu L, Wu Y, Bian Z, et al. Minocycline inhibits microglial inflammation and improves motor function after spinal cord injury in rats. Acta Pharmacol Sin  2021; 42(1): 54-64.
 [http://dx.doi.org/10.1038/s41401-020-00550-4] [PMID: 32451414]

[75]
Zhao H, Li L, Zhang C, et al. Bcl-2 inhibitor ABT-199 exacerbates ischemic brain injury by promoting thrombin-induced neuronal apoptosis in rats. J Neuroinflammation  2019; 16(1): 45.
 [http://dx.doi.org/10.1186/s12974-019-1449-3] [PMID: 30782181]

[76]
Kim JY, Kim YH, Lee YJ, et al. Transcranial magnetic stimulation with robotic hand rehabilitation in stroke patients: A randomized controlled trial. Int J Neurosci  2018; 128(1): 28-36.

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DOI https://dx.doi.org/10.2174/0115743624250965231116060824	Print ISSN 1574-3624
Publisher Name Bentham Science Publisher	Online ISSN 2212-389X

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The Effect of Transcranial Photobiomodulation for Motor Performance Improvement in Patients with Brain Disorders

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