Experimental Cancer Prevention by InsP6 & Inositol

Abstract

Myo-inositol and InsP₆ have independent anticancer action against divergent types of malignancies in a consistent and reproducible manner. The anti-cancer action is dose-dependent and inositol acts synergistically with InsP₆ to enhance the anticancer action of the latter. Since inositol and InsP₆ are common constituents of cereals and legumes, comparative study of high bran diet with equivalent amount of InsP₆ showed that while the ‘high fiber’ diet failed to reduce the incidence of experimental cancer, InsP₆ alone at equivalent dose significantly inhibited mammary cancer formation. Combined with the other studies, these data strongly suggest that supplementation with pure inositol + InsP₆ may be better than gobbling a large amount of fiber.

Keywords: AOM, CD, colitis, Crohn’s disease, DMBA, DMH, pre-initiation, post-initiation, tumor promoter, UC, ulcerative colitis.