Abstract
Angiogenesis is the formation of new blood vessels from the pre-existing ones. It forms the core of the metastatic cascade, since the tumor cells needs nutrition for their growth at distant sites. The work by Folkman et al., has led to a significant understanding of the angiogenesis process and development of novel anti-cancer strategies based on angiogenesis inhibition. In the present chapter we have discussed various pro-angiogenic and anti-angiogenic molecules that are involved in angiogenesis. Further, we have tried to summarise the various molecules both natural and synthetic that inhibit angiogenesis and are being used as novel strategies for the treatment of cancer.
Keywords: Angiogenesis, angiogenic switch, cancer, endothelial cells, growth factors, hypoxia, integrins, metastasis, natural inhibitors, signaling pathway, STAT-3, synthetic inhibitors, targeting, VEGF.
Related Journals
Drug Delivery Letters
Recent Advances in Anti-Infective Drug Discovery
Applied Drug Research, Clinical Trials and Regulatory Affairs
Current Bioactive Compounds
Current Drug Delivery
Current Drug Safety
Drug Metabolism and Bioanalysis Letters
Recent Advances in Drug Delivery and Formulation
Reviews on Recent Clinical Trials
Current Drug Targets - Inflammation & Allergy
Related Books
A Comprehensive Text Book on Self-emulsifying Drug Delivery Systems
Angiogenesis & Therapeutic Targets In Cancer
Biopolymers In Drug Delivery: Recent Advances and Challenges
Chemoinformatics: Directions Toward Combating Neglected Diseases
Current Advances in Drug Delivery Through Fast Dissolving/Disintegrating Dosage Forms
Current Technologies To Increase The Transdermal Delivery Of Drugs
Current Technologies To Increase The Transdermal Delivery Of Drugs
Drug Design and Discovery in Alzheimer's Disease
Frontiers in Anti-Cancer Drug Discovery
Frontiers in Anti-Cancer Drug Discovery