Abstract
Angiogenesis plays a pivotal role in progression of both solid and hematologic tumors. We have focused on multiple myeloma (MM) and its bone marrow stromal cells which are not only a support for tumor cell survival, but also active inducers of angiogenesis by releasing a broad number of angiogenic cytokines. Also, stromal cells such as macrophages and mast cells can participate in blood vessels formation in MM through other processes, such as a vasculogenic mimicry. Finally, it has been discovered that hematopoietic stem and progenitor cells (HSPCs) are involved in the vasculogenesis of MM.
About this chapter
Cite this chapter as:
Maria Fico, Giuseppe Mangialardi, Roberto Ria, Michele Moschetta, Domenico Ribatti, Angelo Vacca ;Role of Stromal Cells in Neovascularization of Multiple Myeloma, Recent Advances in Angiogenesis and Antiangiogenesis (2009) 1: 80. https://doi.org/10.2174/978160805004810901010080
DOI https://doi.org/10.2174/978160805004810901010080 |
Publisher Name Bentham Science Publisher |