Recent Extensions of IDA-based Sensing Protocols

Abstract

With the advancement of supramolecular chemistry in the realm of sensing, researchers across the globe have developed various evolutionary extensions of IDAs from time to time. These comprise enantioselective indicator displacement assays (eIDAs), intramolecular indicator displacement assays (I-IDAs), indicator catalyst displacement assays (ICDA), reaction-based indicator displacement assays (R-IDAs), mechanically controlled indicator displacement assays (MC-IDAs), allosteric indicator displacement assays (A-IDAs), catalytic chemosensing assay (CCA), dimer dye assembly assay (DDA), and quencher displacement assay (QDA). All these evolutionary extensions of IDAs have been discussed in detail from concept to applications along with the possible future outcomes. The authors are of the viewpoint that this chapter will develop a better understanding of the researchers worldwide in the context of the advancement of IDAs.

Keywords: Analyte, Allosteric, Chiral analyte, Catalyst, Coordination, Dye, Displacement, Extensions, Enantiomer, Enantiomeric excess, Intramolecular indicator, Mechanical force, Optical signal, Quencher, Receptor, Recognition, Sensing, Signal modulation.