The Historical Overview of Stem Cells

Pp: 1-17 (17)

* (Excluding Mailing and Handling)

Abstract

Stem cells of hierarchical clustering have emerged as alternative and promising sources for tissue engineering and regenerative medicine. Owing to the unique self-renewal and multi-lineage differentiation attributes, stem cell-based cytotherapy has evoked great expectations in handling numerous refractory and recurrent diseases. Of note, quality control (QC), good manufacturing practice (GMP), and guidelines for stem cells and the derivations are prerequisites for evaluating the safety and efficacy of stem cell-based remedies. In this book, we principally focus on the definition, classification, signatures and functions, safety and efficacy of stem cells, together with the core concerns upon stem cell-based clinical applications and investigational new drug (IND) and new drug application (NDA). Collectively, this book will effectively benefit the novel stem cell-based tissue engineering and regenerative medicine.

Keywords: Amniotic stem cells, Constitutive microenvironment, Embryonic stem cells, Exosomes and small microvesicles, Hematopoietic stem cells, Hematopoietic-supporting effect, Immunomodulation, Immunoregulatory property, Induced pluripotent stem cells, Investigational new drug, Mesenchymal stem/stromal cells, Multipotent stem cells, Neural stem cells, Pluripotent stem cells, Refractory and recurrent disease, Regenerative medicine, Stem cells, Tissue engineering, Totipotent stem cells, Uni-potent stem cells.