Importance of Nanocarriers in Colon Cancer

Pp: 228-254 (27)

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Abstract

Colon cancer is the third most common cause of cancer globally and leads to many deaths. Conventional chemotherapy has severe side effects and toxicities, which are significant challenges for cancer treatment. Current therapy has an essential concern of target specificity. In colon cancer, the primary concern is to deliver the drug to cancer cells in the colon in a reproducible and predictable manner. The oral route has its limitations. The drug delivered through this route gets degraded or may not be subsequently absorbed to produce the effects or lessen them before reaching the colon. Nanocarriers empowered the delivery of chemotherapeutics at specific sites and enhanced cellular penetrability. Within the organism, the cytotoxic substance will quickly accumulate. The present chapter focuses on the different nanostructures designed to deliver the drugs to treat colon cancer.

Keywords: Colon cancer, Chemotherapy, Nanocarriers, Nanoparticles.

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