Heme-oxygenase and Autophagy connected as a Cytoprotective Mechanism: Potential Therapeutic Target

Pp: 1-27 (27)

* (Excluding Mailing and Handling)

Heme-oxygenase (HO) is an enzyme that catalyzes the main step of heme

degradation generating anti-inflammatory end products with protective roles in

physiologic and pathological situations. The relevance of HO in inflammatory

conditions is well reported through pharmacological and/or genetic modulation,

pointing out its importance in several models of stress such as infection, inflammation,

and oxidative disturbance. Under the referred situations, another well-known protective

process triggered is autophagy, in which defective cytosolic components and organelles

are eliminated via lysosomes. Besides its role on organelles and macromolecules

recycling, autophagy also contributes to cellular homeostasis by generating the

functional blocks required for anabolic reactions. Recently, different studies have

demonstrated a link between HO activity and autophagy activation. In this chapter, we

would like to draw the reader's attention to the interconnection between HO and

autophagy regarding stress response mechanisms, highlighting its importance in

homeostasis maintenance that might be useful in the therapy of inflammatory diseases

in the future.

Keywords: Autophagy, Bilirubin and biliverdin, Carbon monoxide, Curcumin, Cytoprotection, Heme, Heme-oxygenase, HO-therapy, Inflammation, Iron, Macroautophagy, Rapamycin, Reactive oxygen species, Resveratrol.

Cite as

Drug Delivery Letters

Recent Advances in Anti-Infective Drug Discovery

Applied Drug Research, Clinical Trials and Regulatory Affairs

Current Bioactive Compounds

Current Drug Delivery

Current Drug Safety

Drug Metabolism and Bioanalysis Letters

Recent Advances in Drug Delivery and Formulation

Reviews on Recent Clinical Trials

Current Drug Targets - Inflammation & Allergy

A Comprehensive Text Book on Self-emulsifying Drug Delivery Systems

Angiogenesis & Therapeutic Targets In Cancer

Anti-Angiogenesis Drug Discovery and Development

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Chemoinformatics: Directions Toward Combating Neglected Diseases

Current Advances in Drug Delivery Through Fast Dissolving/Disintegrating Dosage Forms

DOI https://doi.org/10.2174/9789815036879122110003	Print ISSN 1574-0889
Publisher Name Bentham Science Publisher	Online ISSN 2212-1064

Frontiers in Drug Design and Discovery