Dengue Viral Protein Interaction Study Derived Immune Epitope for In-Silico Vaccine Design

Pp: 77-83 (7)

Abstract

Dengue viral illness is communicated to humans through the bite of female Aedes aegypti mosquitoes. This disease may become lethal in numerous patients. The availability of an efficacious vaccine makes alarm for public healthcare. The dengue virus multiplied inside the host framework involved many host-viral protein interactions. This immunoinformatics study was designed for the prediction of immune epitopes for T cell-mediated immunity. The epitopes are anticipated from the most connecting viral protein with humans. We utilized a couple of epitope mapping tools for the determination of immunodominant epitope for vaccine design. The physical interaction between epitope ligand and receptor MHC class I alleles was analyzed in the molecular docking study. This study was concluded that two epitopes (‘SRAIWYMWL’ and ‘FLEFEALGF’) are suitable for the designing of an efficacious multi-epitope vaccine. The clinical validation is considered necessary for the final confirmation of vaccine potency.

Keywords: Conservancy, Dengue, Epitope, Host, Immunogenicity, Immunoinformatics, Protein-interaction, Vaccine, Virus.