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Review Article

和谐生物材料，用于就地方法在局部地区提供抗癌药物的开发：当前趋势

卷 27, 期 21, 2020

页: [3463 - 3498] 页: 36

弟呕挨: 10.2174/1573406415666190621095726

价格: $65

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摘要

局部药物递送是有效递送抗癌药的新方法，因为它使肿瘤暴露于高浓度的药物中。原位胶凝系统由于其靶向递送，易于制备，延长或持续的药物释放以及改善的患者依从性而在局部癌症化学疗法领域引起了极大的关注。已经研究了许多聚合物的特性，例如溶胀以及生物降解，药物释放和物理化学特性，以成功地将药物靶向到植入部位。聚合物，例如壳聚糖，透明质酸（HA），泊洛沙姆，聚乙醇酸乳酸（PGLA）和聚乳酸（PLA）倾向于在原位形成水凝胶，并已被用于开发局部递送载体。这些制剂以溶液形式给药，并在暴露于诸如温度，pH或离子组合物的生理环境中时经历相转化为水凝胶药物贮库。原位胶凝方法的使用为通过减少对正常细胞的暴露和减轻全身性副作用来增强药物对肿瘤部位的生物利用度提供了提高癌症患者总体生存率和生活质量的前景。由于其良好的安全性和临床益处，美国食品和药物管理局（U.S. FDA）批准了基于聚合物的原位系统以延长局部区域的活性。本文讨论了开发用于靶向递送抗癌药的原位系统的原理，特别强调了用于配制原位系统的聚合物类型。本文还详细讨论了市售的，正在临床试验中的局部抗癌药物递送原位制剂。

关键词: 局部区域，原位凝胶，抗癌药，生物材料，商业制剂，临床试验。

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