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Review Article

生物组织和代谢组学的高分辨率核磁共振光谱

卷 26, 期 12, 2019

页: [2190 - 2207] 页: 18

弟呕挨: 10.2174/0929867326666190312130155

价格: $65

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摘要

高分辨率核磁共振（NMR）光谱是一种通用的分析工具。它可以提供有关化学位移，J耦合常数，多重峰模式和相对峰面积的详细信息。它在化学，生物学，医学和药学领域发挥着重要作用。高度均匀的磁场是获得出色光谱分辨率的先决条件。然而，在一些情况下，例如体内和离体生物组织，由于样品中的磁化率变化引起的磁场不均匀性是不可避免的并且难以通过常规方法消除。基于分子间多量子相干性和常规单量子相干性的技术可以消除场不均匀性效应的影响，并且可以应用于获得生物组织的高分辨率NMR光谱，包括体内动物和人体组织。宽带1H同源解耦核磁共振波谱显示J耦合共振作为坍塌的单峰，导致高度分辨的光谱。它可用于获取某些药物的高分辨率光谱。 J差异编辑的光谱可用于检测J偶联的代谢物，例如γ-氨基丁酸，其检测受到强烈的相邻峰的干扰。高分辨率1H NMR光谱已广泛用于生物流体的鉴定和表征，是药物发现，药物开发和疾病诊断的重要工具。

关键词: 核磁共振（NMR），高分辨率，分子间多重相干（iMQC），单量子相干，同源解耦（纯移），结构解析，J-差异编辑，代谢组学.

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