Login Register Cart 0
Generic placeholder image

Current Drug Delivery

Editor-in-Chief

ISSN (Print): 1567-2018
ISSN (Online): 1875-5704

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Commentary

Lectins and Nanostructured Drug Delivery Systems

Author(s): Marcos Luciano Bruschi*

Volume 16, Issue 3, 2019

Page: [268 - 269] Pages: 2

DOI: 10.2174/1567201816666181122105548

conference banner
Abstract

The advances and the impact of nanostructured systems on therapeutics constitute a constantly evolving reality. New strategies have been developed for drug delivery control and for directing these systems to the targeted site improving the therapy. In this commentary, the lectins are briefly reviewed; their fundamentals and the proposed applications as ligands in nanostructured drug delivery systems are discussed.

Keywords: Nanotechnology, nanomedicine, proteins, targeting, drug delivery system, ligands, strategies.

« Previous
[1]
Pusztai, A.; Bardocsz, S.; Ewen, S.W.B. In: Bioadhesive Drug Delivery Systems- Fundamentals, Novel Approaches, and Development; Mathiowitz, E.; Chickering III, D.E.; Lehr, C-M., Eds.; Marcel Dekker: New York, 1999, Vol. 98, pp. 387-407.
[2]
Smart, J.D. Lectin-mediated drug delivery in the oral cavity. Adv. Drug Deliv. Rev., 2004, 56, 481-489.
[3]
Juan, L.L.; Recio, V.G.; Lopez, P.J.; Juan, T.G.; Cordoba-Diaz, M.; Cordoba-Diaz, D. Pharmaceutical applications of lectins. J. Drug Deliv. Sci. Technol., 2017, 42, 126-133.
[4]
Carvalho, F.C.; Bruschi, M.L.; Evangelista, R.C.; Gremião, M.P.D. Mucoadhesive drug delivery systems. Braz. J. Pharm. Sci., 2010, 46(1), 1-17.
[5]
Bruschi, M.L. Strategies to modify the drug delivery from pharmaceutical systems; Woodheading Publishing-Elsevier: London, 2015.
[6]
García-Díaz, M.; Birch, D.; Wan, F.; Nielsen, H.M. The role of mucus as an invisible cloak to transepithelial drug delivery by nanoparticles. Adv. Drug Deliv. Rev., 2018, 124, 107-124.
[7]
Farokhzad, O.C.; Langer, R. Nanomedicine: Developing smarter therapeutic and diagnostic modalities. Adv. Drug Deliv. Rev., 2006, 58, 1456-1459.
[8]
Campbell, B.J. In: Bioadhesive Drug Delivery Systems- Fundamentals, Novel Approaches, and Development; Mathiowitz, E.; Chickering III, D.E.; Lehr, C-M., Eds.; Marcel Dekker: New York, 1999, Vol. 98, pp. 85-130.
[9]
Cagliari, R.; Kremer, F.S.; da Silva Pinto, L. Bauhinia lectins: biochemical properties and biotechnological applications. Int. J. Biol. Macromol., 2018, 119, 811-820.
[10]
Stillmark, H. Üeber ricin, ein giftiges ferment aus den samen von Ricinus comm. L. und einigen anderen Euphorbiaceen, MD Dissertation, University of Dorpat: Dorpat,. 1888.
[11]
Sharon, N. Lectins: Past, present and future. Biochem. Soc. Trans., 2008, 36(6), 1457-1460.
[12]
Bies, C.; Lehr, C.M.; Woodley, J.F. Lectin-mediated drug targeting: history and applications. Adv. Drug Deliv. Rev., 2004, 56(4), 425-435.
[13]
Neumann, D.; Lehr, C-M.; Lenhof, H-P.; Kohlbacher, O. Computational modeling of the sugar-lectin interaction. Adv. Drug Deliv. Rev., 2004, 56, 467-457.
[14]
Gabor, F.; Bogner, E.; Weissenboeck, A.; Wirth, M. The lectin-cell interaction and its implications to intestinal lectin-mediated drug delivery. Adv. Drug Deliv. Rev., 2004, 56, 459-480.
[15]
Hägerström, H. Polymer gels as pharmaceutical dosage forms: rheological performance and physicochemical interactions at the gel–mucus interface for formulations intended for mucosal drug delivery. Acta Universitatis Upsaliensis. Uppsala: Comprehensive Summaries of Uppsala Dissertations from the Faculty of Pharmacy, Series 293; 2003, 76 pp.
[16]
Andrews, G.P.; Laverty, T.P.; Jones, D.S. Mucoadhesive polymeric platforms for controlled drug delivery. Eur. J. Pharm. Biopharm., 2009, 71, 505-518.
[17]
Bruschi, M.L.; de Freitas, O. Oral bioadhesive drug delivery systems. Drug Dev. Ind. Pharm., 2005, 31, 293-310.
[18]
Bruschi, M.L.; Jones, D.S.; Panzeri, H.; Gremião, M.P.D.; de Freitas, O.; Lara, E.H.G. Semisolid systems containing propolis for the treatment of periodontal disease: In vitro release kinetics, syringeability, rheological, textural, and mucoadhesive properties. J. Pharm. Sci., 2007, 96(8), 2074-2089.
[19]
Bruschi, M.L.; de Freitas, O.; Lara, E.H.G.; Panzeri, H.; Gremião, M.P.D.; Jones, D.S. Precursor system of liquid crystalline phase containing propolis microparticles for the treatment of periodontal disease: Development and characterization. Drug Dev. Ind. Pharm., 2008, 34, 267-278.
[20]
Bassi da Silva, J.; Ferreira, S.B.S.; de Freitas, O.; Bruschi, M.L. A critical review about methodologies for the analysis of mucoadhesive properties of drug delivery systems. Drug Dev. Ind. Pharm., 2017, 43(7), 1053-1070.
[21]
Apfelthaler, C.; Gassenbauer, P.; Weisse, S.; Gabor, F.; Wirth, M. lectin mediated delivery system for the intravesical treatment of bladder diseases using poly-(L)-glutamic acid as polymeric backbone. Eur. J. Pharm. Sci., 2018, 111, 376-382.

Rights & Permissions Print Cite
Article Metrics
79
8
1
1
Wayfinder Image
© 2024 Bentham Science Publishers | Privacy Policy