Login Register Cart 0
Generic placeholder image

Recent Patents on Food, Nutrition & Agriculture

Editor-in-Chief

ISSN (Print): 2212-7984
ISSN (Online): 1876-1429

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Research Article

Hepatoprotective Effects of Algerian Crataegus oxyacantha Leaves

Author(s): Amira Mecheri, Wassila Benabderrahmane, Amel Amrani *, Nassima Boubekri, Fadila Benayache, Samir Benayache and Djamila Zama

Volume 10, Issue 1, 2019

Page: [70 - 75] Pages: 6

DOI: 10.2174/2212798410666180730095456

Price: $65

Open Access Journals Promotions 2
conference banner
Abstract

Background: Hawthorn (C. oxyacantha), a common edible plant, is widely used for the preparation of a different foodstuff and is also used in traditional medicine to treat heart problems and gastrointestinal ailments. Recently, a few patents of Crataegus preparation for protective effects (prevention of cardiovascular and hepatic diseases) have been developed.

Objective: The current study aimed to explore the antioxidant and hepatoprotective effects of nbutanol extract of Crataegus oxyacantha leaves in acute liver damage induced by Doxorubicin (DOX).

Methods: Crataegus oxyacantha (100 mg/kg body weight) or vitamin E as a standard antioxidant (100 mg/kg body weight) were administered orally to female rats for 10 days, in the presence or absence of hepatotoxicity induced by a single intraperitoneal (i.p.) injection of DOX (15 mg/kg on the 8th day). On day 11, blood and liver samples were analyzed for biomarker levels and histopathological changes. Liver homogenates were used for determination of oxidative stress parameters that include Malondialdehyde (MDA), Glutathione (GSH) level and Glutathione Peroxidase (GPx) activity.

Results: Treatment with n-butanol extract of C. oxyacantha leaves significantly improved the altered liver enzyme activities and oxidative stress markers. The histopathological observations confirm the results of biochemical parameters.

Conclusion: The obtained results support the traditional use of C. oxyacantha to cure gastrointestinal ailments and highlighted its possible use in the food and pharmaceutical industries as a source of natural antioxidant.

Keywords: Crataegus oxyacantha, antioxidant, hepatoprotective, doxorubicin, hepatotoxicity, oxidative stress.

« Previous Next »
Graphical Abstract

[1]
Koçkar MC, Nazıroğlu M, Celik O, Tola HT, Bayram D, Koyu A. N-acetylcysteine modulates doxorubicin-induced oxidative stress and antioxidant vitamin concentrations in liver of rats. Cell Biochem Funct 2010; 28(8): 673-7.
[2]
Pieniążek A, Czepas J, Piasecka-Zelga J, Gwoździński K, Koceva-Chyła A. Oxidative stress induced in rat liver by anticancer drugs doxorubicin, paclitaxel and docetaxel. Adv Med Sci 2013; 58(1): 104-11.
[3]
Boutabet K, Kebsa W, Alyane M, Lahouel M. Polyphenolic fraction of Algerian propolis protects rat kidney against acute oxidative stress induced by doxorubicin. Indian J Nephrol 2011; 21(2): 101-6.
[4]
Rashid S, Ali N, Nafees S, Ahmad ST, Arjumand W, Hasan SK, et al. Alleviation of doxorubicin-induced nephrotoxicity and hepatotoxicity by chrysin in Wistar rats. Toxicol Mech Methods 2013; 23(5): 337-45.
[5]
Giampieri F, Alvarez-Suarez JM, Gasparrini M, Forbes-Hernandez TY, Afrin S, Bompadre S, et al. Strawberry consumption alleviates doxorubicin-induced toxicity by suppressing oxidative stress. Food Chem Toxicol 2016; 94: 128-37.
[6]
Quiles JL, Huertas JR, Battino M, Mataix J, Ramírez-Tortosa MC. Antioxidant nutrients and adriamycin toxicity. Toxicology 2002; 180(1): 79-95.
[7]
Liu K, Azamimi Abdullah A, Huang M, Nishioka T. Altaf-Ul-Amin Md, et alNovel approach to classify plants based on metabolite-content similarity. BioMed Res Int 2017; 2017: 5296729.
[8]
Ruiz-Rodríguez BM, de Ancos B, Sánchez-Moreno C, Fernández-Ruiz V, de Cortes Sánchez-Mata M, Cámara M, et al. Wild blackthorn (Prunus spinosa L.) and hawthorn (Crataegus monogyna Jacq.) fruits as valuable sources of antioxidants. Fruits 2014; 69(1): 61-73.
[9]
Nabavi SF, Habtemariam S, Ahmed T, Sureda A, Daglia M, Sobarzo-Sánchez E, et al. Polyphenolic composition of Crataegus monogyna Jacq.: From chemistry to medical applications. Nutrients 2015; 7(9): 7708-28.
[10]
Kumar D, Arya V, Bhat Z, Khan NA, Prasad DN. The genus Crataegus: Chemical and pharmacological perspectives. Rev Bras Farmacogn 2012; 22(5): 1187-200.
[11]
Wang J, Xiong X, Feng B. Effect of Crataegus usage in cardiovascular disease prevention: An evidence-based approach. Evid Based Complement Alternat Med 2013; 2013: 149363.
[12]
Verma SK, Jain V, Verma D, Khamesra R. Crataegus oxyacantha- A Cardioprotective Herb. J Herbal Med Toxicol 2007; 1(1): 65-71.
[13]
Liao BS, Liao JF, Alex L, et al. Lipid metabolism and Fructus crataegus. US20040132816 2004.
[14]
Liao BS, Liao JF, Alex L, et al. Method for preventing and/or treating the cardiovascular and hepatic diseases induced by hyperlipidemia which comprises administered an effective amount of bioflavonoids extract derived from fructus crataegus (lipid metabolism and Fructus crataegus). US11226862 2005.
[15]
Uchiyama M, Mihara M. Determination of malonaldehyde precursor in tissues by thribarbituric acid test. Anal Biochem 1978; 86: 271-8.
[16]
Flohe L, Gunzler WA. Analysis of glutathione peroxidase. Methods Enzymol 1984; 105: 114-21.
[17]
Lowry OH, Rosegrough NJ, Farr AL, Randall RJ. Protein measurement with the folin phenol reagent. J Biol Chem 1951; 193: 265-75.
[18]
Ellman GL. Plasma Antioxidants. Arch Biochem Biophys 1959; 82: 70-7.
[19]
Mohajeri M, Sahebkar A. Protective effects of curcumin against doxorubicin-induced toxicity and resistance: A review. Crit Rev Oncol Hematol 2018; 122: 30-51.
[20]
Lee IC, Kim SH, Baek HS, Moon C, Bae CS, Kim SH, et al. Melatonin improves adriamycin-induced hepatic oxidative damage in rats. Mol Cell Toxicol 2013; 9: 257-65.
[21]
Karakilcik AZ, Bitiren M, Zerin M, Celik H, Aksoy N. Melatonin increased vitamin C and antioxidant enzyme values in the plasma, heart, liver, and kidney of adriamycin-treated rats. Turk J Biol 2015; 39: 925-31.
[22]
Mustafa HN, El-Awdan SA, Hegazy GA, Abdel JGA. Prophylactic role of coenzyme Q10 and Cynara scolymus L. on doxorubicin-induced toxicity in rats: Biochemical and immunohistochemical study. Indian J Pharmacol 2015; 47(6): 649-56.
[23]
Djebbari R, Chemam Y, Boubekri N, Lakroun Z, Kebieche M, Amrani A, et al. Chemoprotective potential of Helianthemum confertum against the loss of molecular and functional integrity of the liver cell in doxorubicin-treated rats. IJPPR 2017; 9(7): 903-10.
[24]
Giampieri F, Alvarez-Suarez JM, Gasparrini M, Forbes-Hernandez TY, Afrin SBS, et al. Strawberry consumption alleviates doxorubicin-induced toxicity by suppressing oxidative stress. Food Chem Toxicol 2016; 94: 128-37.
[25]
Indu R, Azhar TS, Nair A, Nair CK. Amelioration of doxorubicin induced cardio-and hepato-toxicity by carotenoids. J Cancer Res Ther 2014; 10(1): 62-7.
[26]
Jambhulkar S, Deshireddy S, Jestadi DB, Periyasamy L. Quercetin attenuating doxorubicin induced hepatic, cardiac and renal toxicity in male albino wistar rats. JPCT 2014; 8(2): 985-1004.
[27]
Ayaz SA, Bhandari U, Pillai KK. Influence of DL α-lipoic acid and vitamin-E against doxorubicin-induced biochemical and histological changes in the cardiac tissue of rats. Indian J Pharmacol 2005; 37(5): 294-9.
[28]
Krajka-Kuźniak V, Paluszczak J, Oszmiański J, Baer-Dubowska W. Hawthorn (Crataegus oxyacantha L.) bark extract regulates antioxidant response element (ARE)-mediated enzyme expression via Nrf2 pathway activation in normal hepatocyte cell line. Phytother Res 2014; (4): 593-602.
[29]
Martínez-Rodríguez JL, Reyes-Estrada CA, Gutiérrez-Hernández R, López JA. Antioxidant, hypolipidemic and preventive effect of hawthorn (Crataegus oxyacantha) on alcoholic liver damage in rats. J Pharmacognosy Phytother 2016; 8(11): 193-202.
[30]
Rezaei-Golmisheh A, Malekinejad H, Asri-Rezaei S, Farshid AA, Akbari P. Hawthorn ethanolic extracts with triterpenoids and flavonoids exert hepatoprotective effects and suppress the hypercholesterolemia-induced oxidative stress in rats. Iran J Basic Med Sci 2015; 18(7): 691-9.
[31]
Kalender Y, Yel M, Kalender S. Toxicology. Doxorubicin hepatotoxicity and hepatic free radical metabolism in rats : The effects of vitamin E and catechin. Toxicology 2005; 209(1): 39-45.
[32]
Gokcimen A, Cim A, Tola HT, Bayram D, Kocak A, Ozguner F, et al. Protective effect of N-acetylcysteine, caffeic acid and vitamin E on doxorubicin hepatotoxicity. Hum Exp Toxicol 2007; 26: 519-25.
[33]
Benabderrahmane W, Lores M, Lamas JP, Benayache S. Matrix solid-phase dispersion as a tool for phytochemical and bioactivities characterization: Crataegus oxyacantha L. A Case Study. Nat Prod Res 2017; 32(10): 1220-3.
[34]
Llesuy SF, Arnaiz SL. Hepatotoxicity of mitoxantrone and doxorubicin. Toxicology 1990; 63(2): 187-98.
[35]
Al-Syaad K, Ibrahim EH. The protective effects of the aqueous extract of Saliva against biochemical and histopathological changes in kidney and liver of male rats treated with the anticancer drug doxorubicin. RJPBCS 2014; 5(6): 237-45.

Rights & Permissions Print Cite
Article Metrics
75
2
© 2024 Bentham Science Publishers | Privacy Policy