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Review Article

新辅助疗法对可切除的胰腺癌至关重要

卷 26, 期 40, 2019

页: [7196 - 7211] 页: 16

弟呕挨: 10.2174/0929867325666180413101722

价格: $65

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摘要

背景：对新辅助疗法的益处的意识正在提高，但是对于可切除的胰腺癌患者，其作为最初的治疗选择仍存在争议，特别是对于那些没有高风险预后特征的患者。即使对于具有高风险特征的患者，他们也有可能接受新辅助治疗，但也没有标准的治疗方案。方法：在本综述中，我们通过搜索PubMed / MEDLINE，ClinicalTrials.gov，Web of Science和Cochrane库，检查了可切除胰腺癌患者新辅助治疗的可用数据，包括前瞻性研究，回顾性研究和正在进行的临床试。 。描述了筛选研究的特征和结果。结果：包括具有报告结果的回顾性和前瞻性研究以及正在进行的随机研究。对于可切除的胰腺癌患者，由于多模式治疗完成率的提高，新辅助疗法具有诸如提高生存率，降低合并症和死亡率的风险以及提高成本效益等优点。诸如FOLFIRINOX（亚叶酸，氟尿嘧啶，伊立替康和奥沙利铂）或吉西他滨加纳布紫杉醇等高活性方案被认为是可接受的治疗方案。此外，某些患者可以接受除FOLFIRINOX以外的含铂方案。正在探索其他疗法，例如化学放射疗法，免疫肿瘤药和靶向疗法，并高度期待其结果。结论：本综述强调了新辅助疗法对可切除胰腺癌的益处。一些方案目前是可以接受的，但是需要经过精心设计的临床试验的更多证据，或者应在多学科团队的仔细检查后使用。

关键词: 可切除的胰腺癌，新辅助疗法，新辅助化疗方案，新辅助化疗放疗，胰腺导管腺癌，新疗法。

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