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Review Article

用于诊断阿尔茨海默病的99mTc标记的小分子：过去，近期和未来的观点

卷 26, 期 12, 2019

页: [2166 - 2189] 页: 24

弟呕挨: 10.2174/0929867325666180410104023

价格: $65

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摘要

背景：阿尔茨海默病（AD）是一种与年龄相关的进行性神经退行性疾病。其突出的标志是β-淀粉样蛋白（淀粉样斑块）的细胞外沉积，细胞内神经原纤维缠结（NTF），神经变性以及最终丧失认知功能。因此，早期AD诊断和疾病监测非常重要。 方法：在本综述文章中，我们回顾了最近为99mTc标记的小分子的AD成像设计，合成和评估所做的努力。 结果：这些小分子包括刚果红，苯并噻唑，苯并呋喃，苯并恶唑，萘，联苯，查尔酮，黄酮，噢，芪，姜黄素，二苄基丙酮，喹喔啉等衍生物.99mTc标记的小分子的不同方面包括化学结构，将讨论它们对淀粉样斑块的亲和力，BBB渗透和体内/体外稳定性。 结论：本综述的结果证实了99mTc标记的小分子对AD成像的重要性。基于这些设计化合物的药效团的未来研究是改进这些分子用于临床应用所必需的。

关键词: 阿尔茨海默病，99mTc，小分子，AD成像，β-淀粉样蛋白斑，SPECT。

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