The Influence of Inflammatory Cytokines on the Proliferation and Osteoblastic Differentiation of MSCs

Title:The Influence of Inflammatory Cytokines on the Proliferation and Osteoblastic Differentiation of MSCs

Volume: 12 Issue: 5

Author(s): Juan Liu, Bin Chen, Fuhua Yan*Wenrong Yang

Affiliation:

• Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, Jiangsu,China

Keywords: Inflammatory cytokines, mesenchymal stem cells (MSCs), osteoblastic differentiation, osteogenic differentiation.

Abstract: Background: Mesenchymal stem cells (MSCs) have been widely researched for the function of wound repair and bone regeneration. Numerous evidence have proved that MSCs can differentiate towards osteoblasts, and enhance bone formation, and then directly promote the process of bone regeneration.

Objective: The researchers’ interest in MSCs focuses on the potential of differentiating towards osteoblasts. They suggest that these applications can be significantly influenced by different kinds of inflammatory cytokines. In particular, in the process of bone regeneration, MSCs and inflammatory cytokines interact with each other, and promote the process of bone healing.

In this review, we attempt to summarize several inflammatory cytokines that may have influence on the osteogenic differentiation of MSCs, including interleukin 1 (IL-1), IL-6, IL-10, IL-17, tumor necrosis factor-α (TNF-α ), and interferon-γ (INF-γ ), bone morphogenetic proteins(BMPs). Finally, some perspective of the behavior of MSCs in response to inflammatory cytokines are discussed.

Cite this article as:

Liu Juan , Chen Bin , Yan Fuhua *, Yang Wenrong , The Influence of Inflammatory Cytokines on the Proliferation and Osteoblastic Differentiation of MSCs, Current Stem Cell Research & Therapy 2017; 12 (5) . https://dx.doi.org/10.2174/1574888X12666170509102222

DOI https://dx.doi.org/10.2174/1574888X12666170509102222	Print ISSN 1574-888X
Publisher Name Bentham Science Publisher	Online ISSN 2212-3946