Immune Tolerance of Mesenchymal Stem Cells and Induction of Skin Allograft Tolerance

Title:Immune Tolerance of Mesenchymal Stem Cells and Induction of Skin Allograft Tolerance

Volume: 12 Issue: 5

Author(s): Tengxiao Ma, Xiao Wang and Duyin Jiang*

Affiliation:

• Department of Plastic Surgery and Burns, The Second Hospital of Shandong University, Jinan, Shandong 250033,,China

Keywords: Mesenchymal stem cells, immunosuppression, immune tolerance, skin allograft.

Abstract: Background: Mesenchymal stem cells not only possess reparative properties, but also have immunomodulatory effect. Owing to the properties, they have been proposed to be hopeful candidates for cell therapy in the process of organ transplantation. In the preclinical researches, it shows that MSCs is capable of prolonging graft survival and inducing tolerance in some cases. Various mechanisms of immune tolerance were reported before, such as tolerogenic dendritic cells, induction of apoptosis, regulatory T cells, mixed chimerism, soluble factors and anergy. Furthermore, the induction of immune tolerance may be influenced by the dose, route and optimal timing of MSCs administration. Allograft of skin can provisionally restore the function of skin barrier and offer a good environment to expand micro-skin auto-graft; however, at the same time, it can cause strong immune rejection, which leads to the failure of skin graft.

Cite this article as:

Ma Tengxiao, Wang Xiao and Jiang Duyin*, Immune Tolerance of Mesenchymal Stem Cells and Induction of Skin Allograft Tolerance, Current Stem Cell Research & Therapy 2017; 12 (5) . https://dx.doi.org/10.2174/1574888X12666170301122744