围产期感染和双相情感障碍的暴露：一个系统评价

Title:Exposure to Perinatal Infections and Bipolar Disorder: A Systematic Review

Volume: 16 Issue: 2

Author(s): T. Barichello, M. Badawy, M.R. Pitcher, P. Saigal, J.S. Generoso, J.A. Goularte, L.R. Simoes, J. Quevedo and A.F. Carvalho

Affiliation:

关键词: 双相情感障碍，母体感染，疱疹，流感，弓形虫，系统评价。

摘要: Bipolar disorder (BD) is a debilitating psychiatric disorder and a growing global public health issue. Notwithstanding BD has been conceptualized as a neuroprogressive illness, there are some evidences to suggest a role for neurodevelopmental pathways in the patho-etiology of this disorder. Evidences on the associations between perinatal infections and risk for bipolar disorder have been inconsistent across studies. Here, we performed a systematic review of observational studies on the relationship between exposure to perinatal pathogens and bipolar disorder. A computerized literature search of the PubMed, Embase, and PsyINFO databases till January 31^st, 2015 was performed. Twenty-three studies ultimately met inclusion criteria. Studies investigated exposure to several pathogens namely Cytomegalovirus (CMV), Epstein–Barr Virus (EBV), Herpes simplex virus-1 (HSV-1), Herpes simplex virus-2 (HSV-2), Human herpesvirus 6 (HHV-6), Toxoplasma gondii, Influenza, and Varicella zoster virus (VZV). Overall, studies provided mixed evidences. Thus, contrary to schizophrenia, the role of perinatal infections as risk factors for BD remain inconclusive. Larger studies with a prospective design would be necessary to elucidate the role of previous exposure to infectious agents as a potential risk factor for BD.

Cite this article as:

T. Barichello, M. Badawy, M.R. Pitcher, P. Saigal, J.S. Generoso, J.A. Goularte, L.R. Simoes, J. Quevedo and A.F. Carvalho , Exposure to Perinatal Infections and Bipolar Disorder: A Systematic Review, Current Molecular Medicine 2016; 16 (2) . https://dx.doi.org/10.2174/1566524016666160126143741