Abstract
Baculovirus has been widely utilized as a protein production tool in insect cells for nearly 3 decades and has captured growing interests as a vector for gene delivery into mammalian cells and animals over the past decade. This review summarizes important patents pertaining to the use of baculovirus for insect cell infection and mammalian cell transduction, with special emphasis on the vector development, new applications and downstream processing.
Keywords: Baculovirus, expression system, insect cell, mammalian cell, vaccine, mammalian cell transduction, downstream processing, nucleopolyhedrovirus, replication, human interferon, DNA cloning capacity, Rous Sarcoma Virus (RSV), cytomegalovirus (CMV), long terminal repeat (LTR) promoter, eucaryotic proteins, delivery of vaccine immunogens, polyadenylation sequence
Call for Papers in Thematic Issues
Advancements in Plant Genetics and Genomics
This thematic issue will highlight cutting-edge innovations and recent patents across the breadth of plant genetics and genomics. Key topics will include advanced breeding techniques, omics-based approaches, gene editing, trait discovery, and translational applications for crop improvement. Renowned researchers from leading institutions worldwide will provide state-of-the-art insights and future perspectives ...read more
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