Structural and Pharmacological Features of Phospholipases A2 from Snake Venoms

Title: Structural and Pharmacological Features of Phospholipases A2 from Snake Venoms

Volume: 16 Issue: 8

Author(s): Rafael Cisne de Paula, Helena Carla Castro, Carlos Rangel Rodrigues, Paulo Assis Melo and Andre Lopes Fuly

Affiliation:

Keywords: Phospholipases A2, snake venom, mechanism of action, inhibitors, lysophosphatidylcholine, binding receptors

Abstract: Phospholipases A2 enzymes are found in many biological sources, including snake venoms. Here we reviewed aspects of PLA2s including biological and structural features, interaction with binding receptors, inhibitors used on structure- function relationship studies and highlighting the mechanism of action and role of the snake venom PLA2s products, the lysophosphatidylcholine.

Cite this article as:

de Paula Cisne Rafael, Castro Carla Helena, Rodrigues Rangel Carlos, Melo Assis Paulo and Fuly Lopes Andre, Structural and Pharmacological Features of Phospholipases A2 from Snake Venoms, Protein & Peptide Letters 2009; 16 (8) . https://dx.doi.org/10.2174/092986609788923365