Calcium-Independent Membrane Damage by Venom Phospholipases A2

Title: Calcium-Independent Membrane Damage by Venom Phospholipases A2

Volume: 16 Issue: 8

Author(s): A.H.C. de Oliveira, E. A. Aragao, J. M. Sa, L. Chioato, R. Bugs-Bortoleto, R. Ruller, T. L. Ferreira and R. J. Ward

Affiliation:

Keywords: Membrane permeabilization, molecular mechanism, micelle nucleation

Abstract: Many snake venom phospholipase A2s (vPLA2s) present biological effects that are independent of hydrolytic activity. Here we review the evidence for the calcium-independent membrane damaging activity of vPLA2s, the possible relevance of this activity on their biological effects, and models for the mechanism of membrane permeabilization by these proteins.

Cite this article as:

de Oliveira A.H.C., Aragao A. E., Sa M. J., Chioato L., Bugs-Bortoleto R., Ruller R., Ferreira L. T. and Ward J. R., Calcium-Independent Membrane Damage by Venom Phospholipases A2, Protein & Peptide Letters 2009; 16 (8) . https://dx.doi.org/10.2174/092986609788923392