Abstract
It is suggested that the interactions between the hydrophobic C-H groups of carbohydrate residues and the p-electron systems of aromatic amino-acid residues play an important role in the ligand-recognition function of carbohydrate-binding proteins. This review focuses on our recent structural and functional studies of human lysozyme and hevein-domain type lectins (wheat-germ agglutinin and Ac-AMP2) aimed at understanding how CH / π interactions are involved in the actual binding events.
Keywords: interaction, carbohydrate binding protein, cbp interaction
Protein & Peptide Letters
Title: The Importance of Ch / π Interactions to the Function of Carbohydrate Binding Proteins
Volume: 9 Issue: 3
Author(s): Michiro Muraki
Affiliation:
Keywords: interaction, carbohydrate binding protein, cbp interaction
Abstract: It is suggested that the interactions between the hydrophobic C-H groups of carbohydrate residues and the p-electron systems of aromatic amino-acid residues play an important role in the ligand-recognition function of carbohydrate-binding proteins. This review focuses on our recent structural and functional studies of human lysozyme and hevein-domain type lectins (wheat-germ agglutinin and Ac-AMP2) aimed at understanding how CH / π interactions are involved in the actual binding events.
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Cite this article as:
Muraki Michiro, The Importance of Ch / π Interactions to the Function of Carbohydrate Binding Proteins, Protein & Peptide Letters 2002; 9 (3) . https://dx.doi.org/10.2174/0929866023408751
DOI https://dx.doi.org/10.2174/0929866023408751 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
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Plants are still the major repository of biologically active substances. In the last two decades, however, natural peptides and proteins of plant origin have gained increasing attention due to their pharmacological activities over a variety of human illnesses, including those mediated by infections and parasitosis and those involving different cellular ...read more
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