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Protein & Peptide Letters

Editor-in-Chief

ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

The Importance of Ch / π Interactions to the Function of Carbohydrate Binding Proteins

Author(s): Michiro Muraki

Volume 9, Issue 3, 2002

Page: [195 - 209] Pages: 15

DOI: 10.2174/0929866023408751

Price: $65

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Abstract

It is suggested that the interactions between the hydrophobic C-H groups of carbohydrate residues and the p-electron systems of aromatic amino-acid residues play an important role in the ligand-recognition function of carbohydrate-binding proteins. This review focuses on our recent structural and functional studies of human lysozyme and hevein-domain type lectins (wheat-germ agglutinin and Ac-AMP2) aimed at understanding how CH / π interactions are involved in the actual binding events.

Keywords: interaction, carbohydrate binding protein, cbp interaction


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