α-Synuclein Aggregation

Title: α-Synuclein Aggregation

Volume: 11 Issue: 3

Author(s): Angela M. Bodles and G. Brent Irvine

Affiliation:

Keywords: synuclein, amyloid, aggregation, parkinsons disease

Abstract: α-Synuclein is a major component of Lewy bodies in Parkinsons disease and is found associated with several other forms of dementia. As with other neurodegenerative diseases, the ability of α-synuclein to aggregate and form fibrillar deposits seems central to its pathology. We have defined a sequence within the NAC region of α-synuclein that is necessary for aggregation. Exploitation of chemically modified analogues of this peptide may produce inhibitors of aggregation.

Cite this article as:

Bodles M. Angela and Irvine Brent G., α-Synuclein Aggregation, Protein & Peptide Letters 2004; 11 (3) . https://dx.doi.org/10.2174/0929866043407084