Focusing on Enzyme Suppression in Neurodegenerative Disorders: Promising Approaches for Therapeutic Measures

Title:Focusing on Enzyme Suppression in Neurodegenerative Disorders: Promising Approaches for Therapeutic Measures

Volume: 5

Author(s): Shivendra Kumar*, Sunam Saha, Talever Singh, Ram Babu Tripathi, Kuldeep Singh, Vivek Dwivedi, Shubham Singh and Deep Chandra

Affiliation:

• Department of Pharmacy, Rajiv Academy for Pharmacy, Mathura (U.P.), India

Keywords: Neurodegenerative diseases, Enzyme dysregulation, Enzyme inhibition, Preclinical studies, Clinical studies, Molecular biology.

Abstract: Neurodegenerative diseases, characterized by the progressive degeneration of neurons, represent a significant and growing global health concern. Despite extensive research, the underlying molecular mechanisms driving these conditions remain elusive. Enzyme dysregulation has emerged as a pivotal player in the pathogenesis of various neurodegenerative disorders, including Alzheimer's, Parkinson's, and Huntington's diseases. Understanding and targeting these enzymes hold immense therapeutic potential for mitigating disease progression. This abstract summarizes the current state of knowledge regarding the involvement of enzymes in neurodegenerative diseases and explores the potential therapeutic interventions aimed at enzyme inhibition. First, we provide an overview of the key enzymes implicated in each disorder and highlight their specific roles in neurodegenerative processes. Next, we delve into the intricate interplay between enzyme dysregulation and disease progression, elucidating the cascade of events leading to neuronal death and cognitive decline. Additionally, we explore promising preclinical and clinical studies that have shown encouraging results in inhibiting specific enzymes, validating the therapeutic potential of targeting these pathways. In conclusion, targeting enzyme inhibition in neurodegenerative diseases holds immense promise as a therapeutic avenue to slow disease progression and improve patients' quality of life. Nevertheless, considerable challenges lie ahead, necessitating collaborative efforts among researchers, clinicians, and pharmaceutical companies to develop safe, effective, and precise interventions for combating these devastating disorders. With continued advancements in molecular biology and drug discovery, we remain optimistic that the targeted modulation of enzymes will pave the way for innovative and transformative treatments in the realm of neurodegenerative diseases.

Cite this article as:

Kumar Shivendra*, Saha Sunam, Singh Talever, Tripathi Ram Babu, Singh Kuldeep, Dwivedi Vivek, Singh Shubham and Chandra Deep, Focusing on Enzyme Suppression in Neurodegenerative Disorders: Promising Approaches for Therapeutic Measures, New Emirates Medical Journal 2024; 5 : e02506882311325 . https://dx.doi.org/10.2174/0102506882311325240815105251