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Current Topics in Medicinal Chemistry

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ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

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Review Article

Harnessing Natural Resources for Advancements in Dengue Virus Treatment

Author(s): Nur Aina Najiha Amin Hapis, Nurshamimi Nor Rashid and Yeun-Mun Choo*

Volume 24, Issue 27, 2024

Published on: 27 August, 2024

Page: [2337 - 2350] Pages: 14

DOI: 10.2174/0115680266312717240821062535

Price: $65

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Abstract

Dengue fever, caused by the Dengue virus (DENV) and transmitted by Aedes aegypti mosquitoes, has become endemic in over 100 countries. Despite considerable research, there is a lack of specific drugs for clinical use against dengue. Hence, further exploration to identify antidengue compounds is essential. In recent years, natural products have gained attention for their antiviral properties. Plant-based medicines are particularly appealing due to their safety and low toxicity. This review summarizes natural compounds with potential antiviral activity against DENV, highlighting their mechanisms of action. Various compounds, from traditional herbal remedies to novel plant isolates, show promise against dengue, targeting crucial viral proteins like the envelope protein, proteases, and RNA polymerase. Exploring natural sources of antiviral agents against dengue is crucial. These compounds offer hope for effective treatments and mitigating dengue's global impact.

Keywords: Dengue, DENV, Natural products, E protein, NS1 protein, NS2B-NS3 protease, NS5 protein.

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