Visceral Fat-associated Adipokines and Metabolic Variables in Central Obese Type 2 Diabetic Patients

Title:Visceral Fat-associated Adipokines and Metabolic Variables in Central Obese Type 2 Diabetic Patients

Volume: 5

Author(s): Abid Shaheer*, Ashok Kumar, Mahir Jallo and Palat Menon

Affiliation:

• College of Medicine, Gulf Medical University, Ajman, United Arab Emirates

Keywords: Diabetes, Obesity, Adipokines, Cytokines, Adiponectin, Visfatin.

Abstract:

Background: The association between visceral obesity and insulin resistance establishes an alternative risk for the onset of type 2 diabetes mellitus. The infiltration of macrophages in the visceral fatty tissue and the unreliable generation of adipokines are associated with mechanisms directing the progress of insulin resistance.

Objective: The objective of the study was to observe the relationship between visceral fat-associated adipokines and biochemical variables in central obese type 2 diabetic patients.

Methods: This study included 100 central obese subjects (both genders) aged 30-60 years newly diagnosed with type 2 diabetes mellitus. Out of the 100 participants, 73 were male and 27 were female. Serum adipokines were analyzed using an enzyme-linked immunosorbent assay. Biochemical parameters were assessed using the Cobas® 6000 analyzer, while HbA1c levels were determined through high-performance liquid chromatography.

Results: The results showed a significant relationship (p < 0.05) between the adipokines and HbA1c, fasting, and postprandial blood glucose levels. The results indicated a significant association (p < 0.05) between the adipokines and lipid profile with varying degrees in central obese type 2 diabetic subjects. Conclusion:

The relationship between visceral fat-associated adipokines and metabolic variables may influence the metabolic pathways in central obese type 2 diabetic patients. The adipokines are strong predictors for the intensification of diabetic risk and can be used as a diagnostic tool for risk assessment in the central obese population.

Cite this article as:

Shaheer Abid*, Kumar Ashok, Jallo Mahir and Menon Palat, Visceral Fat-associated Adipokines and Metabolic Variables in Central Obese Type 2 Diabetic Patients, New Emirates Medical Journal 2024; 5 : e02506882293086 . https://dx.doi.org/10.2174/0102506882293086240422102329