Technical Considerations, Applications, and Benefits of Organogels in
Topical Drug Delivery Systems

Abhishek      Yadav; Vikas      Jhawat; Rahul   Pratap   Singh; Sunita      Chauhan; Rohit      Dutt; Rajesh      Goyal; Deependra      Singh

doi:10.2174/0126673878277455240214110033

Abstract

Organogels represent semi-solid systems where an organic liquid phase is entrapped within a three-dimensional network formed by self-assembled, crosslinked, or entangled gelator fibers. These versatile materials find applications in a wide range of fields, including chemistry, pharmaceuticals, cosmetics, biotechnology, and food technology. Notably, in pharmacology, they serve as valuable platforms for drug and vaccine delivery, facilitating the transport of active ingredients through various routes such as transdermal, oral, and parenteral. However, their previous utility as drug delivery systems was hindered by the toxicity associated with the organic solvents used. The pharmacokinetics of medications delivered via organogels are primarily influenced by the distinctive properties of these materials, specifically their "high permeability and poor aqueous solubility," which can impact the bioavailability of the drugs. Organogels can be employed topically or for the controlled release of medications through cutaneous administration and percutaneous absorption, expanding their scope of application beyond conventional drug delivery methods. Organogels hold significant promise as drug delivery vehicles due to their biocompatibility, non-irritating properties, and thermoremanent characteristics. They enable the formulation of diverse drug delivery systems by incorporating both hydrophilic and hydrophobic bioactive compounds within the gel matrix. This comprehensive review offers an overview of organogels, encompassing their nature, synthesis, characterization, and properties. Special attention is directed towards cutting-edge technologies employed in designing organogels as potential controlled delivery systems, with a focus on their emerging therapeutic applications.

Keywords: Organogels, skin permeation, drug delivery, topical route, solubility, bioavailability.

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DOI https://dx.doi.org/10.2174/0126673878277455240214110033	Print ISSN 2667-3878
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Recent Advances in Drug Delivery and Formulation

Technical Considerations, Applications, and Benefits of Organogels in Topical Drug Delivery Systems

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