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Current Topics in Medicinal Chemistry

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ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

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Review Article

Repurposing of Plant-based Antiviral Molecules for the Treatment of COVID-19

Author(s): Jabeena Khazir, Sajad Ahmed, Rakesh Kr Thakur, Manzoor Hussain, Sumit G. Gandhi, Sadhana Babbar, Shabir Ahmad Mir, Nusrat Shafi, Libert Brice Tonfack, Vijay Rani Rajpal*, Tariq Maqbool*, Bilal Ahmad Mir* and Latif Ahmad Peer*

Volume 24, Issue 7, 2024

Published on: 20 February, 2024

Page: [614 - 633] Pages: 20

DOI: 10.2174/0115680266276749240206101847

Price: $65

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Abstract

COVID-19, stemming from SARS-CoV-2, poses a formidable threat to global healthcare, with a staggering 77 million confirmed cases and 690,067 deaths recorded till December 24, 2023. Given the absence of specific drugs for this viral infection, the exploration of novel antiviral compounds becomes imperative. High-throughput technologies are actively engaged in drug discovery, and there is a parallel effort to repurpose plant-based molecules with established antiviral properties. In this context, the review meticulously delves into the potential of plant-based folk remedies and existing molecules. These substances have showcased substantial viral inhibition in diverse in vivo, in silico, and in vitro studies, particularly against critical viral protein targets, including SARS-CoV-2. The findings position these plant-based molecules as promising antiviral drug candidates for the swift advancement of treatments for COVID-19. It is noteworthy that the inherent attributes of these plant-based molecules, such as their natural origin, potency, safety, and cost-effectiveness, contribute to their appeal as lead candidates. The review advocates for further exploration through comprehensive in vivo studies conducted on animal models, emphasizing the potential of plant-based compounds to help in the ongoing quest to develop effective antivirals against COVID-19.

Keywords: Medicinal plants, Drug molecules, SARS-CoV-2, Plant-based antivirals, COVID-19, Middle Eastern Respiratory Syndrome (MERS).

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