Login Register Cart 0
Generic placeholder image

Endocrine, Metabolic & Immune Disorders - Drug Targets

Editor-in-Chief

ISSN (Print): 1871-5303
ISSN (Online): 2212-3873

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Review Article

Promising Influences of Moringa oleifera in Functional Foods against Metabolic Syndrome: A Comprehensive and Mechanistic Review

Author(s): Mohammad Masoumvand, Elmira Ramezani, Vafa Baradaran Rahimi and Vahid Reza Askari*

Volume 24, Issue 12, 2024

Published on: 25 January, 2024

Page: [1355 - 1370] Pages: 16

DOI: 10.2174/0118715303269893231207071440

Price: $65

conference banner
Abstract

Metabolic syndrome (MetS) is now considered a global issue with a growing financial and health impact. Numerous herbal alternatives have been examined and researched due to the ever-increasing demand for new medications to treat metabolic syndrome disorders. People have empirically employed Moringa oleifera (MO), a native plant to several Asian nations, for a variety of diseases. We sought to examine recent research on MO in MetS and its potential mechanism of action in the current review. Four databases, including PubMed, Scopus, Web of Sciences, and Google Scholar, were thoroughly searched, and the data were then compiled. In total, 146 papers covering nonclinical and clinical MO investigations in metabolic syndromerelated disorders are included in this study. Numerous research confirmed MO's positive impact on the control of blood glucose, blood pressure, hyperlipidemia, and obesity. Many molecular processes have been investigated, including increasing glucose transporter type 4 (GLUT4) expression, inhibition of β-Hydroxy-β-methylglutaryl-coenzyme A (HMG-CoA), α-glucosidase inhibiting, AMP-activated protein kinase (AMPK) activation, and other suggested mechanisms. The current review established much data favoring MO's potential advantages in metabolic syndrome. However, further research involving human studies is required in this area to determine whether Moringa can effectively treat metabolic syndrome.

Keywords: Moringa oleifera, metabolic syndrome, diabetes, dyslipidemia, obesity, herbal alternatives.

« Previous Next »
Graphical Abstract

[1]
Eckel, R.H.; Grundy, S.M.; Zimmet, P.Z. The metabolic syndrome. Lancet, 2005, 365(9468), 1415-1428.
[http://dx.doi.org/10.1016/S0140-6736(05)66378-7] [PMID: 15836891]
[2]
Mokhayeri, Y.; Riahi, S.M.; Rahimzadeh, S.; Pourhoseingholi, M.A.; Hashemi-Nazari, S.S. Metabolic syndrome prevalence in the Iranian adult’s general population and its trend: A systematic review and meta-analysis of observational studies. Diabetes Metab. Syndr., 2018, 12(3), 441-453.
[http://dx.doi.org/10.1016/j.dsx.2017.12.023] [PMID: 29292185]
[3]
Baradaran, R.V.; Askari, V.R.; Hosseinzadeh, H. Promising influences of Scutellaria baicalensis and its two active constituents, baicalin, and baicalein, against metabolic syndrome: A review. Phytother. Res., 2021, 35(7), 3558-3574.
[http://dx.doi.org/10.1002/ptr.7046] [PMID: 33590943]
[4]
Hamilton, M.T.; Hamilton, D.G.; Zderic, T.W. Role of low energy expenditure and sitting in obesity, metabolic syndrome, type 2 diabetes, and cardiovascular disease. Diabetes, 2007, 56(11), 2655-2667.
[http://dx.doi.org/10.2337/db07-0882] [PMID: 17827399]
[5]
Wilson, P.W.F.; D’Agostino, R.B.; Parise, H.; Sullivan, L.; Meigs, J.B. Metabolic syndrome as a precursor of cardiovascular disease and type 2 diabetes mellitus. Circulation, 2005, 112(20), 3066-3072.
[http://dx.doi.org/10.1161/CIRCULATIONAHA.105.539528] [PMID: 16275870]
[6]
Meigs, J.B.; Wilson, P.W.F.; Fox, C.S.; Vasan, R.S.; Nathan, D.M.; Sullivan, L.M.; D’Agostino, R.B. Body mass index, metabolic syndrome, and risk of type 2 diabetes or cardiovascular disease. J. Clin. Endocrinol. Metab., 2006, 91(8), 2906-2912.
[http://dx.doi.org/10.1210/jc.2006-0594] [PMID: 16735483]
[7]
Ranasinghe, P.; Mathangasinghe, Y.; Jayawardena, R.; Hills, A.P.; Misra, A. Prevalence and trends of metabolic syndrome among adults in the asia-pacific region: A systematic review. BMC Public Health, 2017, 17(1), 101.
[http://dx.doi.org/10.1186/s12889-017-4041-1] [PMID: 28109251]
[8]
Friend, A.; Craig, L.; Turner, S. The prevalence of metabolic syndrome in children: A systematic review of the literature. Metab. Syndr. Relat. Disord., 2013, 11(2), 71-80.
[http://dx.doi.org/10.1089/met.2012.0122] [PMID: 23249214]
[9]
Delavari, A.; Forouzanfar, M.H.; Alikhani, S.; Sharifian, A.; Kelishadi, R. First nationwide study of the prevalence of the metabolic syndrome and optimal cutoff points of waist circumference in the Middle East: The national survey of risk factors for noncommunicable diseases of Iran. Diabetes Care, 2009, 32(6), 1092-1097.
[http://dx.doi.org/10.2337/dc08-1800] [PMID: 19279302]
[10]
Bouguerra, R.; Alberti, H.; Smida, H.; Salem, L.B.; Rayana, C.B.; El Atti, J.; Achour, A.; Gaigi, S.; Slama, C.B.; Zouari, B.; Alberti, K.G.M.M. Waist circumference cut‐off points for identification of abdominal obesity among the tunisian adult population. Diabetes Obes. Metab., 2007, 9(6), 859-868.
[http://dx.doi.org/10.1111/j.1463-1326.2006.00667.x] [PMID: 17924868]
[11]
Adedapo, A.; Mogbojuri, O.; Emikpe, B. Safety evaluations of the aqueous extract of the leaves of Moringa oleifera in rats. J. Med. Plants Res., 2009, 3(8), 586-591.
[12]
Mbikay, M. Therapeutic potential of Moringa oleifera leaves in chronic hyperglycemia and dyslipidemia: A review. Front. Pharmacol., 2012, 3, 24.
[http://dx.doi.org/10.3389/fphar.2012.00024] [PMID: 22403543]
[13]
Stohs, S.J.; Hartman, M.J. Review of the safety and efficacy of Moringa oleifera. Phytother. Res., 2015, 29(6), 796-804.
[http://dx.doi.org/10.1002/ptr.5325] [PMID: 25808883]
[14]
Padayachee, B. Baijnath, H. An updated comprehensive review of the medicinal, phytochemical and pharmacological properties of Moringa oleifera. South African J. Botany, 2020, 129, 304-316.
[http://dx.doi.org/10.1016/j.sajb.2019.08.021]
[15]
Kumar, S.; Bhattacharya, A.; Tiwari, P.; Sahu, P.K. A review of the phytochemical and pharmacological characteristics of Moringa oleifera. J. Pharm. Bioallied Sci., 2018, 10(4), 181-191.
[http://dx.doi.org/10.4103/JPBS.JPBS_126_18] [PMID: 30568375]
[16]
Pareek, A. Pant, M: Gupta, M.M: Kashania, P: Ratan, Y: Jain, V. Moringa oleifera: An updated comprehensive review of its pharmacological activities, ethnomedicinal, phytopharmaceutical formulation, clinical, phytochemical, and toxicological aspects. Int. J. Mol. Sci., 2023, 24(3), 2098.
[http://dx.doi.org/10.3390/ijms24032098]
[17]
Leone, A.; Spada, A.; Battezzati, A.; Schiraldi, A.; Aristil, J.; Bertoli, S. Cultivation, genetic, ethnopharmacology, phytochemistry and pharmacology of Moringa oleifera leaves: An overview. Int. J. Mol. Sci., 2015, 16(12), 12791-12835.
[http://dx.doi.org/10.3390/ijms160612791] [PMID: 26057747]
[18]
Vergara-Jimenez, M.; Almatrafi, M.; Fernandez, M. Bioactive components in Moringa oleifera leaves protect against chronic disease. Antioxidants, 2017, 6(4), 91.
[http://dx.doi.org/10.3390/antiox6040091] [PMID: 29144438]
[19]
Islam, Z.; Islam, S.M.R.; Hossen, F.; Mahtab-ul-Islam, K.; Hasan, M.R.; Karim, R. Moringa oleifera is a prominent source of nutrients with potential health benefits. Int. J. Food Sci., 2021, 2021, 1-11.
[http://dx.doi.org/10.1155/2021/6627265] [PMID: 34423026]
[20]
Pal, S.K.; Mukherjee, P.K.; Saha, B.P. Studies on the antiulcer activity of Moringa oleifera leaf extract on gastric ulcer models in rats. Phytother. Res., 1995, 9(6), 463-465.
[http://dx.doi.org/10.1002/ptr.2650090618]
[21]
Oyedepo, T.; Babarinde, S.; Ajayeoba, T. Evaluation of anti-hyperlipidemic effect of aqueous leaves extract of Moringa oleifera in alloxan induced diabetic rats. Int. J. Biochem. Res. Rev., 2013, 3(3), 162-170.
[http://dx.doi.org/10.9734/IJBCRR/2013/3639]
[22]
Faizi, S.; Siddiqui, B.; Saleem, R.; Aftab, K.; Shaheen, F.; Gilani, A.H. Hypotensive constituents from the pods of Moringa oleifera. Planta Med., 1998, 64(3), 225-228.
[http://dx.doi.org/10.1055/s-2006-957414] [PMID: 9581519]
[23]
Rao, K.; Mishra, S. Anti-inflammatory and antihepatotoxic activities of the roots of Moringa pterygosperma Gaertn. Indian J. Pharm. Sci., 1998, 60(1), 12.
[24]
Bennett, R.N.; Mellon, F.A.; Foidl, N.; Pratt, J.H.; Dupont, M.S.; Perkins, L.; Kroon, P.A. Profiling glucosinolates and phenolics in vegetative and reproductive tissues of the multi-purpose trees Moringa oleifera L. (horseradish tree) and Moringa stenopetala L. J. Agric. Food Chem., 2003, 51(12), 3546-3553.
[http://dx.doi.org/10.1021/jf0211480] [PMID: 12769522]
[25]
Tahiliani, P.; Kar, A. Role of Moringa oleifera leaf extract in the regulation of thyroid hormone status in adult male and female rats. Pharmacol. Res., 2000, 41(3), 319-323.
[http://dx.doi.org/10.1006/phrs.1999.0587] [PMID: 10675284]
[26]
Peter, A. Walter, A: Wagai, S: Joseph, O. Antibacterial activity of Moringa oleifera and Moringa stenopetala methanol and n-hexane seed extracts on bacteria implicated in water borne diseases. Afr. J. Microbiol. Res., 2011, 5(2)
[27]
Anwar, F.; Latif, S.; Ashraf, M.; Gilani, A.H. Moringa oleifera: A food plant with multiple medicinal uses. Phytother. Res., 2007, 21(1), 17-25.
[http://dx.doi.org/10.1002/ptr.2023] [PMID: 17089328]
[28]
Mahajan, S.G.; Banerjee, A.; Chauhan, B.F.; Padh, H.; Nivsarkar, M.; Mehta, A.A. Inhibitory effect of n-butanol fraction of Moringa oleifera Lam. seeds on ovalbumin-induced airway inflammation in a guinea pig model of asthma. Int. J. Toxicol., 2009, 28(6), 519-527.
[http://dx.doi.org/10.1177/1091581809345165] [PMID: 19966143]
[29]
Hamza, A.A. Ameliorative effects of Moringa oleifera Lam seed extract on liver fibrosis in rats. Food Chem. Toxicol., 2010, 48(1), 345-355.
[http://dx.doi.org/10.1016/j.fct.2009.10.022] [PMID: 19854235]
[30]
Pari, L.; Kumar, N.A. Hepatoprotective activity of Moringa oleifera on antitubercular drug-induced liver damage in rats. J. Med. Food, 2002, 5(3), 171-177.
[http://dx.doi.org/10.1089/10966200260398206] [PMID: 12495589]
[31]
Halaby, M.S.; Metwally, E.; Omar, A. Effect of Moringa oleifera on serum lipids and kidney function of hyperlipidemic rats. J. Appl. Sci. Res., 2013, 9, 5189-5198.
[32]
Okwari, O.; Dasofunjo, K.; Asuk, A.; Alagwu, E.; Mokwe, C. Anti-hypercholesterolemic and hepatoprotective effect of aqueous leaf extract of Moringa oleifera in rats fed with thermoxidized palm oil diet. J. Pharm. Biol. Sci., 2013, 8, 57-62.
[33]
Efiong, E.; Igile, G.; Mgbeje, B.; Otu, E.; Ebong, P. Hepatoprotective and anti-diabetic effect of combined extracts of Moringa oleifera and Vernonia amygdalina in streptozotocin-induced diabetic albino Wistar rats. J. Endocrinol. Diabetes, 2013, 4(4), 45-50.
[34]
Jaiswal, D.; Kumar, R.P.; Kumar, A.; Mehta, S.; Watal, G. Effect of Moringa oleifera Lam. leaves aqueous extract therapy on hyperglycemic rats. J. Ethnopharmacol., 2009, 123(3), 392-396.
[http://dx.doi.org/10.1016/j.jep.2009.03.036] [PMID: 19501271]
[35]
Araújo, L.C.C.; Aguiar, J.S.; Napoleão, T.H.; Mota, F.V.B.; Barros, A.L.S.; Moura, M.C.; Coriolano, M.C.; Coelho, L.C.B.B.; Silva, T.G.; Paiva, P.M.G. Evaluation of cytotoxic and anti-inflammatory activities of extracts and lectins from Moringa oleifera seeds. PLoS One, 2013, 8(12), e81973.
[http://dx.doi.org/10.1371/journal.pone.0081973] [PMID: 24349164]
[36]
Adedapo, A.A.; Falayi, O.O.; Oyagbemi, A.A. Evaluation of the analgesic, anti-inflammatory, anti-oxidant, phytochemical and toxicological properties of the methanolic leaf extract of commercially processed Moringa oleifera in some laboratory animals. J. Basic Clin. Physiol. Pharmacol., 2015, 26(5), 491-499.
[http://dx.doi.org/10.1515/jbcpp-2014-0105] [PMID: 26020553]
[37]
Waterman, C.; Rojas-Silva, P.; Tumer, T.B.; Kuhn, P.; Richard, A.J.; Wicks, S.; Stephens, J.M.; Wang, Z.; Mynatt, R.; Cefalu, W.; Raskin, I. Isothiocyanate‐rich Moringa oleifera extract reduces weight gain, insulin resistance, and hepatic gluconeogenesis in mice. Mol. Nutr. Food Res., 2015, 59(6), 1013-1024.
[http://dx.doi.org/10.1002/mnfr.201400679] [PMID: 25620073]
[38]
Sun, C.; Li, W.; Liu, Y.; Deng, W.; Adu-Frimpong, M.; Zhang, H.; Wang, Q.; Yu, J.; Xu, X. In vitro/in vivo hepatoprotective properties of 1-O-(4-hydroxymethylphenyl)-α-L-rhamnopyrano side from Moringa oleifera seeds against carbon tetrachloride-induced hepatic injury. Food Chem. Toxicol., 2019, 131, 110531.
[http://dx.doi.org/10.1016/j.fct.2019.05.039] [PMID: 31136780]
[39]
Chin, C.Y.; Ng, P.Y.; Ng, S.F. Moringa oleifera standardised aqueous leaf extract-loaded hydrocolloid film dressing: in vivo dermal safety and wound healing evaluation in STZ/HFD diabetic rat model. Drug Deliv. Transl. Res., 2019, 9(2), 453-468.
[http://dx.doi.org/10.1007/s13346-018-0510-z] [PMID: 29560587]
[40]
Gao, X.; Xie, Q.; Liu, L.; Kong, P.; Sheng, J.; Xiang, H. Metabolic adaptation to the aqueous leaf extract of Moringa oleifera Lam.-supplemented diet is related to the modulation of gut microbiota in mice. Appl. Microbiol. Biotechnol., 2017, 101(12), 5115-5130.
[http://dx.doi.org/10.1007/s00253-017-8233-5] [PMID: 28382453]
[41]
Daba, M-H.; El-masry, A.; El-Karef, A. Effect of Moringa oleifera with and without metformin on an experimental model of metabolic syndrome in rats. Int. J. Adv. Res., 2015, 3, 1624-1632.
[42]
Othman, A. I: Amer, M.A: Basos, A.S: El-Missiry, M.A. Moringa oleifera leaf extract ameliorated high-fat diet-induced obesity, oxidative stress and disrupted metabolic hormones. Clini Phytosci, 2019, 5(48)
[http://dx.doi.org/10.1186/s40816-019-0140-0]
[43]
Muhammad, N.; Ibrahim, K.G.; Ndhlala, A.R.; Erlwanger, K.H. Moringa oleifera Lam. prevents the development of high fructose diet-induced fatty liver. S. Afr. J. Bot., 2020, 129, 32-39.
[http://dx.doi.org/10.1016/j.sajb.2018.12.003]
[44]
Sandoval, M.A.S.; Jimeno, C.A. Effect of malunggay (Moringa oleifera) capsules on lipid and glucose levels. Acta Med. Philipp., 2013, 47(3)
[http://dx.doi.org/10.47895/amp.v47i3.1285]
[45]
Anthanont, P.; Lumlerdkij, N.; Akarasereenont, P.; Vannasaeng, S.; Sriwijitkamol, A. Moringa oleifera leaf increases insulin secretion after single dose administration: A preliminary study in healthy subjects. J. Med. Assoc. Thai., 2016, 99(3), 308-313.
[PMID: 27276742]
[46]
Adeoye, R.I.; Joel, E.B.; Igunnu, A.; Arise, R.O.; Malomo, S.O. A review of some common African spices with antihypertensive potential. J. Food Biochem., 2022, 46(1), e14003.
[http://dx.doi.org/10.1111/jfbc.14003] [PMID: 34820859]
[47]
Carpéné, C.; Stiliyanov, A.K.; Les, F.; Mercader, B.J. Hyperglycemia and reduced adiposity of streptozotocin-induced diabetic mice are not alleviated by oral benzylamine supplementation. World J. Diabetes, 2022, 13(9), 752-764.
[http://dx.doi.org/10.4239/wjd.v13.i9.752] [PMID: 36188146]
[48]
Aju, B.Y.; Rajalakshmi, R.; Mini, S. Protective role of Moringa oleifera leaf extract on cardiac antioxidant status and lipid peroxidation in streptozotocin induced diabetic rats. Heliyon, 2019, 5(12), e02935.
[http://dx.doi.org/10.1016/j.heliyon.2019.e02935] [PMID: 31872118]
[49]
Estri, K. S. Analysis of the Moringa oleifera seed oil extract on insulin level in alloxan-induced diabetic rat (Rattus norvegicus). Indian J. Med. Forensic Med. Toxicol., 2020, 14(3), 1888-1893.
[50]
Irfan, H.M.; Khan, N.A.K.; Asmawi, M.Z. Moringa oleifera Lam. leaf extracts reverse metabolic syndrome in Sprague Dawley rats fed high-fructose high fat diet for 60-days. Arch. Physiol. Biochem., 2022, 128(5), 1202-1208.
[PMID: 32412306]
[51]
Ndong, M.; Uehara, M.; Katsumata, S.; Sato, S.; Suzuki, K. Preventive effects of Moringa oleifera (Lam) on hyperlipidemia and hepatocyte ultrastructural changes in iron deficient rats. Biosci. Biotechnol. Biochem., 2007, 71(8), 1826-1833.
[http://dx.doi.org/10.1271/bbb.60644] [PMID: 17690476]
[52]
Taweerutchana, R. Lumlerdkij, N: Vannasaeng, S: Akarasereenont, P: Sriwijitkamol, A. Effect of Moringa oleifera leaf capsules on glycemic control in therapy-naive type 2 diabetes patients: A randomized placebo controlled study. Evid. Based Complement. Alternat. Med., 2017, 2017, 6581390.
[http://dx.doi.org/10.1155/2017/6581390]
[53]
Joung, H.; Kim, B.; Park, H.; Lee, K.; Kim, H.H.; Sim, H.C.; Do, H.J.; Hyun, C.K.; Do, M.S. Fermented Moringa oleifera decreases hepatic adiposity and ameliorates glucose intolerance in high-fat diet-induced obese mice. J. Med. Food, 2017, 20(5), 439-447.
[http://dx.doi.org/10.1089/jmf.2016.3860] [PMID: 28504910]
[54]
López, M.; Ríos-Silva, M.; Huerta, M.; Cárdenas, Y.; Bricio-Barrios, J.A.; Díaz-Reval, M.I.; Urzúa, Z.; Huerta-Trujillo, M.; López-Quezada, K.; Trujillo, X. Effects of Moringa oleifera leaf powder on metabolic syndrome induced in male Wistar rats: a preliminary study. J. Int. Med. Res., 2018, 46(8), 3327-3336.
[http://dx.doi.org/10.1177/0300060518781726] [PMID: 29962304]
[55]
Chigurupati, S.; Al-murikhy, A.; Almahmoud, S.A.; Almoshari, Y.; Saber Ahmed, A.; Vijayabalan, S.; Ghazi, F.S.; Raj, P.V. Molecular docking of phenolic compounds and screening of antioxidant and antidiabetic potential of Moringa oleifera ethanolic leaves extract from Qassim region, Saudi Arabia. Saudi J. Biol. Sci., 2022, 29(2), 854-859.
[http://dx.doi.org/10.1016/j.sjbs.2021.10.021] [PMID: 35197753]
[56]
Ullah, M.F.; Bhat, S.H.; Abuduhier, F.M. Antidiabetic potential of hydro-alcoholic extract of Moringa Peregrina Leaves: Implication as functional food for prophylactic intervention in prediabetic stage. J. Food Biochem., 2015, 39(4), 360-367.
[http://dx.doi.org/10.1111/jfbc.12140]
[57]
Mohamed, M.A.; Ahmed, M.A.; El Sayed, R.A. Molecular effects of Moringa leaf extract on insulin resistance and reproductive function in hyperinsulinemic male rats. J. Diabetes Metab. Disord., 2019, 18(2), 487-494.
[http://dx.doi.org/10.1007/s40200-019-00454-7] [PMID: 31890674]
[58]
Ghasi, S.; Nwobodo, E.; Ofili, J.O. Hypocholesterolemic effects of crude extract of leaf of Moringa oleifera Lam in high-fat diet fed wistar rats. J. Ethnopharmacol., 2000, 69(1), 21-25.
[http://dx.doi.org/10.1016/S0378-8741(99)00106-3] [PMID: 10661880]
[59]
Olayaki, L.A.; Irekpita, J.E.; Yakubu, M.T.; Ojo, O.O. Methanolic extract of Moringa oleifera leaves improves glucose tolerance, glycogen synthesis and lipid metabolism in alloxan-induced diabetic rats. J. Basic Clin. Physiol. Pharmacol., 2015, 26(6), 585-593.
[http://dx.doi.org/10.1515/jbcpp-2014-0129] [PMID: 26124050]
[60]
Onyenibe, N.S.; Isreal, F.; Babatunji, O. Moringa oleifera leaves modulate blood glucose concentration, lipid profile and carbohydrate metabolizing enzymes in streptozotocin diabetic rats. World Heart J., 2018, 10(3), 213-222.
[61]
Díaz-Prieto, L.E.; Gómez-Martínez, S.; Vicente-Castro, I.; Heredia, C.; González-Romero, E.A.; Martín-Ridaura, M.C.; Ceinos, M.; Picón, M.J.; Marcos, A.; Nova, E. Effects of Moringa oleifera Lam. supplementation on inflammatory and cardiometabolic markers in subjects with prediabetes. Nutrients, 2022, 14(9), 1937.
[http://dx.doi.org/10.3390/nu14091937] [PMID: 35565903]
[62]
Almatrafi, M.; Vergara-Jimenez, M.; Murillo, A.; Norris, G.; Blesso, C.; Fernandez, M. Moringa leaves prevent hepatic lipid accumulation and inflammation in guinea pigs by reducing the expression of genes involved in lipid metabolism. Int. J. Mol. Sci., 2017, 18(7), 1330.
[http://dx.doi.org/10.3390/ijms18071330] [PMID: 28640194]
[63]
Helmy, S.A.; Morsy, N.F.S.; Elaby, S.M.; Ghaly, M.A.A. Hypolipidemic effect of Moringa oleifera Lam leaf powder and its extract in diet-induced hypercholesterolemic rats. J. Med. Food, 2017, 20(8), 755-762.
[http://dx.doi.org/10.1089/jmf.2016.0155] [PMID: 28459609]
[64]
Bitrus, N.E. Kingsley, UI: Chukwuma, O.O. The role of crude methanol leaf extract of Moringa oleifera in protection against hyperlipidaemia and cardiomyopathy in albino rat fed a high cholesterol diet and carbimazole. Pharmacologyonline, 2018, 3, 261-271.
[65]
Rajanandh, M.G.; Satishkumar, M.N.; Elango, K.; Suresh, B. Moringa oleifera Lam. A herbal medicine for hyperlipidemia: A pre–clinical report. Asian Pac. J. Trop. Dis., 2012, 2, S790-S795.
[http://dx.doi.org/10.1016/S2222-1808(12)60266-7]
[66]
El Rabey, H.A. Khan, J.A: Almutairi, F.M: Elbakry, M.A. The low dose of drumsticks (Moringa oleifera L.) seed powder ameliorates blood cholesterol in hypercholesterolemic male rat. Indian J. Biochem. Biophys., 2017, 54(6), 306-313.
[67]
Chumark, P.; Khunawat, P.; Sanvarinda, Y.; Phornchirasilp, S.; Morales, N.P.; Phivthong-ngam, L.; Ratanachamnong, P.; Srisawat, S.; Pongrapeeporn, K.S. The in vitro and ex vivo antioxidant properties, hypolipidaemic and antiatherosclerotic activities of water extract of Moringa oleifera Lam. leaves. J. Ethnopharmacol., 2008, 116(3), 439-446.
[http://dx.doi.org/10.1016/j.jep.2007.12.010] [PMID: 18249514]
[68]
Elabd, E.M.Y.; Morsy, S.M.; Elmalt, H.A. Investigating of Moringa oleifera role on gut microbiota composition and inflammation associated with obesity following high fat diet feeding. Open Access Maced. J. Med. Sci., 2018, 6(8), 1359-1364.
[http://dx.doi.org/10.3889/oamjms.2018.313] [PMID: 30159057]
[69]
Kim, D.S.; Choi, M.H.; Shin, H.J. Extracts of Moringa oleifera leaves from different cultivation regions show both antioxidant and antiobesity activities. J. Food Biochem., 2020, 44(7), e13282.
[http://dx.doi.org/10.1111/jfbc.13282] [PMID: 32436270]
[70]
Balusamy, S.R.; Perumalsamy, H.; Ranjan, A.; Park, S.; Ramani, S. A dietary vegetable, Moringa oleifera leaves (drumstick tree) induced fat cell apoptosis by inhibiting adipogenesis in 3T3-L1 adipocytes. J. Funct. Foods, 2019, 59, 251-260.
[http://dx.doi.org/10.1016/j.jff.2019.05.029]
[71]
Muni, S.G.; Ramesh, G.; Devi, P.R.; Meriga, B. Astragalin, (3-O-glucoside of kaempferol), isolated from Moringa oleifera leaves modulates leptin, adiponectin secretion and inhibits adipogenesis in 3T3-L1 adipocytes. Arch. Physiol. Biochem., 2022, 128(4), 938-944.
[http://dx.doi.org/10.1080/13813455.2020.1740742] [PMID: 32216601]
[72]
Kilany, O.E.; Abdelrazek, H.M.A.; Aldayel, T.S.; Abdo, S.; Mahmoud, M.M.A. Anti-obesity potential of Moringa olifera seed extract and lycopene on high fat diet induced obesity in male Sprauge Dawely rats. Saudi J. Biol. Sci., 2020, 27(10), 2733-2746.
[http://dx.doi.org/10.1016/j.sjbs.2020.06.026] [PMID: 32994733]
[73]
Metwally, F. M: Rashad, H.M: Ahmed, H.H: Mahmoud, A.A.: Abdol Raouf, E.R: Abdalla, A.M. Molecular mechanisms of the anti-obesity potential effect of Moringa oleifera in the experimental model. Asian Pac. J. Trop. Biomed., 2017, 7(3), 214-221.
[http://dx.doi.org/10.1016/j.apjtb.2016.12.007]
[74]
Gómez-Martínez, S.; Díaz-Prieto, L.E.; Vicente, C.I.V.; Jurado, C.; Iturmendi, N.; Martín-Ridaura, M.C.; Calle, N.; Dueñas, M.; Picón, M.J.; Marcos, A.; Nova, E. Moringa oleifera leaf supplementation as a glycemic control strategy in subjects with prediabetes. Nutrients, 2021, 14(1), 57.
[http://dx.doi.org/10.3390/nu14010057] [PMID: 35010932]
[75]
Bour, S.; Visentin, V.; Prévot, D.; Daviaud, D.; Saulnier-Blache, J.S.; Guigne, C.; Valet, P.; Carpéné, C. Effects of oral administration of benzylamine on glucose tolerance and lipid metabolism in rats. J. Physiol. Biochem., 2005, 61(2), 371-379.
[http://dx.doi.org/10.1007/BF03167054] [PMID: 16180335]
[76]
El-Shehawi, A.M.; Alkafafy, M.; El-Shazly, S.; Sayed, S.; Farouk, S.; Alotaibi, S.; Madkour, D.A.; Khalifa, H.K.; Ahmed, M.M. Moringa oleifera leaves ethanolic extract ameliorates high fat diet-induced obesity in rats. J. King Saud Univ. Sci., 2021, 33(6), 101552.
[http://dx.doi.org/10.1016/j.jksus.2021.101552]
[77]
Li, L.; Ma, L.; Wen, Y.; Xie, J.; Yan, L.; Ji, A.; Zeng, Y.; Tian, Y.; Sheng, J. Crude polysaccharide extracted from Moringa oleifera leaves prevents obesity in association with modulating gut microbiota in high-fat diet-fed mice. Front. Nutr., 2022, 9, 861588.
[http://dx.doi.org/10.3389/fnut.2022.861588] [PMID: 35548566]
[78]
Aktar, S.; Das, P.; Asha, S.; Siddika, M.; Islam, F.; Khanam, J.; Rakib, M. Moringa oleifera leaves methanolic extract inhibits angiotensin converting enzyme activity in vitro which ameliorates hypertension. J. Adv. Biotechnol. Exp Ther., 2019, 2(2), 73-77.
[http://dx.doi.org/10.5455/jabet.2019.d28]
[79]
Kumolosasi, E.; Cheng, C.W.; Abdullah, A.Z.; Abd Manap, N.S.; Lee, W.L.; Yusuf, M.H.; Lo, S.Y.; Buang, F.; Mohd Said, M.; Mohamad, H.F.; Jasamai, M. Antihypertensive activities of standardised Moringa oleifera Lam.(merunggai) extracts in spontaneously hypertensive rats. Sains Malays., 2021, 50(3), 769-778.
[http://dx.doi.org/10.17576/jsm-2021-5003-18]
[80]
Chan, S.M.; Ruhomally, Z.B.; Boojhawon, R.; Neergheen-Bhujun, V.S. Consumption of Moringa oleifera Lam leaves lowers postprandial blood pressure. J. Am. Coll. Nutr., 2020, 39(1), 54-62.
[http://dx.doi.org/10.1080/07315724.2019.1608602] [PMID: 31063434]
[81]
Sana, A.; Saleem, R.; Faizi, S. Hypotensive activity of Moringa oleifera Lam (Moringaceae) root extracts and its volatile constituents. Trop. J. Pharm. Res., 2015, 14(5), 823-830.
[http://dx.doi.org/10.4314/tjpr.v14i5.12]
[82]
Aekthammarat, D.; Pannangpetch, P.; Tangsucharit, P. Moringa oleifera leaf extract lowers high blood pressure by alleviating vascular dysfunction and decreasing oxidative stress in L-NAME hypertensive rats. Phytomedicine, 2019, 54, 9-16.
[http://dx.doi.org/10.1016/j.phymed.2018.10.023] [PMID: 30668387]
[83]
Aderinola, T.A.; Fagbemi, T.N.; Enujiugha, V.N.; Alashi, A.M.; Aluko, R.E. In vitro antihypertensive and antioxidative properties of trypsin‐derived Moringa oleifera seed globulin hydrolyzate and its membrane fractions. Food Sci. Nutr., 2019, 7(1), 132-138.
[http://dx.doi.org/10.1002/fsn3.826] [PMID: 30680166]
[84]
Monraz-Méndez, C.A.; Escutia-Gutiérrez, R.; Rodriguez-Sanabria, J.S.; Galicia-Moreno, M.; Monroy-Ramírez, H.C.; Sánchez-Orozco, L.; García-Bañuelos, J.; De la Rosa-Bibiano, R.; Santos, A.; Armendáriz-Borunda, J.; Sandoval-Rodríguez, A. Moringa oleifera improves MAFLD by inducing epigenetic modifications. Nutrients, 2022, 14(20), 4225.
[http://dx.doi.org/10.3390/nu14204225] [PMID: 36296907]
[85]
Gondo, H.K. Moringa oleifera decrease blood sugar level and blood pressure in pregnant diabetic rats. J. Adv. Pharm. Educ. Res., 2021, 11(2), 88-91.
[http://dx.doi.org/10.51847/FDGccLKxoF]
[86]
Aziz, I.; Saqib, Q.N.; Younus, M.; Ali, E.; Qadir, M.I.; Siddique, F.A.; Wazir, M.A.; Shaheer, M.T.; Adnan, Q.; Shirazi, J.H.; Rehman, K.U.; Ullah, S.; Abbas, K. Physicochemical, antidiarrheal and antidiabetic potential of super food (Moringa oleifera Lam.). Pak. J. Pharm. Sci., 2021, 34(2), 723-729.
[PMID: 34275807]
[87]
Anwer, T.; Safhi, M.M.; Makeen, H.A.; Alshahrani, S.; Siddiqui, R.; Sivakumar, S.M.; Shaheen, E.S.; Alam, M.F. Antidiabetic potential of Moringa oleifera Lam. leaf extract in type 2 diabetic rats, and its mechanism of action. Trop. J. Pharm. Res., 2021, 20(1), 95-103.
[http://dx.doi.org/10.4314/tjpr.v20i1.15]
[88]
Ayuwardani, N.; Hariningsih, Y. Effectiveness of combination of Moringa leaf extract (Moringa oleifera Lamk.) and papaya seed extract (Carica papaya L.) in reducing blood sugar levels of diabetic rats. Pharm. Educ., 2021, 21(2), 215-219.
[http://dx.doi.org/10.46542/pe.2021.212.215219]
[89]
Muhammad Irfan, H.; Zaini Asmawi, M.; Abdul Karim Khan, N.; Bashir, S.; Rasool, Z.; Riaz, H. In-vivo and in-vitro studies to investigate the anti-diabetic mechanisms underlying Moringa oleifera leaf ethanol extracts. Pak. J. Pharm. Sci., 2020, 33(3), 1261-1270.
[90]
Bao, Y.; Xiao, J.; Weng, Z.; Lu, X.; Shen, X.; Wang, F. A phenolic glycoside from Moringa oleifera Lam. improves the carbohydrate and lipid metabolisms through AMPK in db/db mice. Food Chem., 2020, 311, 125948.
[http://dx.doi.org/10.1016/j.foodchem.2019.125948] [PMID: 31877545]
[91]
Nazir, S.; Sulistyo, J.; Hashmi, M.I.; Ho, A.L.; Khan, M.S. Enzymatic synthesis of polyphenol glycosides catalyzed by transglycosylation reaction of cyclodextrin glucanotransferase derived from Trichoderma viride. J. Food Sci. Technol., 2018, 55(8), 3026-3034.
[http://dx.doi.org/10.1007/s13197-018-3223-x] [PMID: 30065412]
[92]
Saleh, S.S.; Sarhat, E.R. Effects of ethanolic Moringa oleifera extract on melatonin, liver and kidney function tests in alloxan-induced diabetic rats. Indian J. Forensic Med Toxicol., 2019, 13(4), 1009.
[http://dx.doi.org/10.5958/0973-9130.2019.00431.6]
[93]
Rengarajan, T.; Bamagous, G.A.; Al Ghamdi, S.S.; Aziz Ibrahim, I.A.; Mahfoz, A.M.; Afify, M.A.; Alsugoor, M.H.M.; Shammah, A.A.; Arulselvan, P. Antidiabetic and antioxidant activity of ethyl acetate extract fraction of Moringa oleifera leaves in streptozotocin-induced diabetes rats via inhibition of inflammatory mediators. Asian Pac. J. Trop. Biomed., 2018, 8(6), 320.
[http://dx.doi.org/10.4103/2221-1691.235327]
[94]
Omodanisi, E.I.; Aboua, Y.G.; Chegou, N.N.; Oguntibeju, O.O. Hepatoprotective, antihyperlipidemic, and anti-inflammatory activity of Moringa oleifera in diabetic-induced damage in male wistar rats. Pharmacognosy Res., 2017, 9(2), 182-187.
[PMID: 28539743]
[95]
Tang, Y.; Choi, E.J.; Han, W.C.; Oh, M.; Kim, J.; Hwang, J.Y.; Park, P.J.; Moon, S.H.; Kim, Y.S.; Kim, E.K. Moringa oleifera from Cambodia ameliorates oxidative stress, hyperglycemia, and kidney dysfunction in type 2 diabetic mice. J. Med. Food, 2017, 20(5), 502-510.
[http://dx.doi.org/10.1089/jmf.2016.3792] [PMID: 28467233]
[96]
Paula, P.; Sousa, D.; Oliveira, J.; Carvalho, A.; Alves, B.; Pereira, M.; Farias, D.; Viana, M.; Santos, F.; Morais, T.; Vasconcelos, I. A protein isolate from Moringa oleifera leaves has hypoglycemic and antioxidant effects in alloxan-induced diabetic mice. Molecules, 2017, 22(2), 271.
[http://dx.doi.org/10.3390/molecules22020271] [PMID: 28208654]
[97]
Sholapur, H.; Patil, B. Effect of Moringa oleifera bark extracts on dexamethasone-induced insulin resistance in rats. Drug Res., 2013, 63(10), 527-531.
[http://dx.doi.org/10.1055/s-0033-1347238] [PMID: 23780503]
[98]
Attakpa, E.S.; Sangaré, M.M.; Béhanzin, G.J.; Ategbo, J.M.; Seri, B.; Khan, N.A. Moringa olifeira Lam. stimulates activation of the insulin-dependent akt pathway. Antidiabetic effect in a diet-induced obesity (DIO) mouse model. Folia Biol., 2017, 63(2), 42-51.
[PMID: 28557705]
[99]
Irfan, H.M.; Asmawi, M.Z.; Khan, N.A.K.; Sadikun, A.; Mordi, M.N. Anti-diabetic activity-guided screening of aqueous-ethanol Moringa oleifera extracts and fractions: Identification of marker compounds. Trop. J. Pharm. Res., 2017, 16(3), 543-552.
[http://dx.doi.org/10.4314/tjpr.v16i3.7]
[100]
El-Desouki, N.I.; Basyony, M.A.; Hegazi, M.A.; El-Aama, M.S.I. Moringa oleifera leaf extract ameliorates glucose, insulin and pancreatic beta cells disorder in alloxan-induced diabetic rats. Res. J. Pharm. Biol. Chem. Sci., 2015, 6(3), 642-654.
[101]
Yassa, H.D.; Tohamy, A.F. Extract of Moringa oleifera leaves ameliorates streptozotocin-induced Diabetes mellitus in adult rats. Acta Histochem., 2014, 116(5), 844-854.
[http://dx.doi.org/10.1016/j.acthis.2014.02.002] [PMID: 24657072]
[102]
Odunlade, A.; Taiwo, I. Effect of Moringa oleifera on hyperglycaemic response induced by subchronic fructose feeding in susceptibility rats. Int. Res. J. Pharm. Appl. Sci., 2013, 3(6), 39-41.
[103]
Gupta, R.; Mathur, M.; Bajaj, V.K.; Katariya, P.; Yadav, S.; Kamal, R.; Gupta, R.S. Evaluation of antidiabetic and antioxidant activity of Moringa oleifera in experimental diabetes. J. Diabetes, 2012, 4(2), 164-171.
[http://dx.doi.org/10.1111/j.1753-0407.2011.00173.x] [PMID: 22103446]
[104]
El-Hofi, M. Assessment of moring oleifera leaves as natural source to produce hypolipidemic and antioxidative functional food. Carpathian J. Food Sci. Technology., 2021, 13(3)
[105]
Madkhali, H.A.; Alharthy, K.M.; Asiri, M.A.; Ganaie, M.A.; Ansari, M.N.; Rehman, N.U. Moringa oleifera Lam. (family Moringaceae) leaf extract attenuates high-fat diet-induced dyslipidemia and vascular endothelium dysfunction in Wistar albino rats. Trop. J. Pharm. Res., 2019, 18(12), 2597-2604.
[106]
Mapfumo, M.; Lembede, B.W.; Ndhlala, A.R.; Chivandi, E. Effect of crude Moringa oleifera Lam. seed extract on the blood markers of metabolic syndrome in high-fructose diet-fed growing Sprague-Dawley rats. J. Complement. Integr. Med., 2019, 17(1)
[PMID: 31421043]
[107]
Reddy, V.; Urooj, A.; Sairam, S.; Ahmed, F.; Prasad, N. Hypocholesterolemic effect of Moringa oleifera polyphenols in rats fed high fat-cholesterol diet. Malays. J. Nutr., 2017, 23(2), 473-478.
[108]
Bais, S. Singh, GS: Sharma, R. Antiobesity and hypolipidemic activity of Moringa oleifera leaves against high fat diet-induced obesity in rats. Adv. Biol., 2014, 2014, 9.
[109]
Jain, P.G.; Patil, S.D.; Haswani, N.G.; Girase, M.V.; Surana, S.J. Hypolipidemic activity of Moringa oleifera Lam., Moringaceae, on high fat diet induced hyperlipidemia in albino rats. Rev. Bras. Farmacogn., 2010, 20(6), 969-973.
[http://dx.doi.org/10.1590/S0102-695X2010005000038]
[110]
Ma, K.; Wang, Y.; Wang, M.; Wang, Z.; Wang, X.; Ju, X.; He, R. Antihypertensive activity of the ACE–renin inhibitory peptide derived from Moringa oleifera protein. Food Funct., 2021, 12(19), 8994-9006.
[http://dx.doi.org/10.1039/D1FO01103K] [PMID: 34382048]
[111]
Batmomolin, A. Ahsan, A: Wiyasa, I.W.A: Santoso, S. Ethanolic extract of Moringa oleifera leaves improve inflammation, angiogenesis, and blood pressure in rat model of preeclampsia. J. Appl. Pharm. Sci., 2020, 10(8), 52.

Rights & Permissions Print Cite
Article Metrics
17
1
Wayfinder Image
World Diabetes Day
© 2024 Bentham Science Publishers | Privacy Policy