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Endocrine, Metabolic & Immune Disorders - Drug Targets

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ISSN (Print): 1871-5303
ISSN (Online): 2212-3873

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Research Article

A Comparison of the Decline in Glomerular Filtration Rate between Elderly Patients with Diabetes and those without Diabetes in Southwest China

Author(s): Qing-Hua Yi, Hong-Liang Wang, Yun Hou, Lang Xu, Wei-Li Tian, Yi-Xuan Zhang, Yu-Shan Xu and Jia-Bin Shi*

Volume 24, Issue 12, 2024

Published on: 11 January, 2024

Page: [1371 - 1376] Pages: 6

DOI: 10.2174/0118715303261963231228125548

Price: $65

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Abstract

Objective: To investigate the effect of high blood glucose on the decline in the estimated glomerular filtration rate (eGFR) in the elderly.

Methods: We compared the decline in eGFR of diabetic and non-diabetic groups in the noninterventional state and analyzed the effect of hyperglycemia on the decline in eGFR among the elderly in a retrospective analysis of 1,223 cases of elderly people aged 65 years or older with a 4-year follow-up period.

Results: The prevalence of diabetes in the elderly increased significantly from 12.67% in 2017 to 16.68% in 2021. The rate of decline in eGFR in patients with diabetes was higher than in the population without diabetes, at 9.29% and 5.32%, respectively (both p <0.05).

Conclusion: The results of this study revealed that the prevalence of diabetes in the elderly increased significantly, and there is a more rapid decrease in the eGFR levels in those with diabetes than those without diabetes.

Keywords: Diabetes, eGFR decline, elderly, non-intervention, inflammation, hyperglycemia.

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