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The Natural Products Journal

Editor-in-Chief

ISSN (Print): 2210-3155
ISSN (Online): 2210-3163

Review Article

Physiologic Effects of Hibiscus sabdariffa (Sorrel) on Biological Systems: Advances in Sorrel Research

Author(s): Garsha McCalla* and Bethany Smith

Volume 14, Issue 7, 2024

Published on: 19 January, 2024

Article ID: e190124225815 Pages: 20

DOI: 10.2174/0122103155273914231206094057

Price: $65

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Abstract

Background: Hibiscus sabdariffa (sorrel) is a member of the hibiscus genus and Malvaceae family. An important attribute is its therapeutic characteristic, which has been validated by research that shows some success in treating several diseases.

Objective: Owing to limited information and research deficits, this study aimed to investigate the physiologic effects of Hibiscus sabdariffa on biological systems and the advances made in the last century.

Methods: PubMed Central search for “Hibiscus sabdariffa OR sorrel” was conducted from November 2021 to March 2022, covering articles from 1921 to 2020. The results were documented in Microsoft Excel 2016 and grouped based on physiological systems.

Results: Sorrel research publications mushroomed in the last decade. Studies from 1921-2010 reported on the endocrine and cardiovascular systems, while additional biological systems (nervous, urinary, gastrointestinal, integumentary, hematopoietic, reproductive, and skeletal) were later investigated. Sorrel positively treated diabetes, hypertension, and a multitude of other illnesses due to its antioxidant, antibacterial, and anti-inflammatory potential, chiefly via its anthocyanins. Hypertension was mostly reported, predominantly from Nigeria (Africa), and toxicity exceeded 2000 mg/kg b.w.

Conclusion: Sorrel has multifaceted uses, mostly involving hypertension treatment. Despite increased publications and advances in research, all areas of physiology still require sorrel research, especially in the Caribbean, which lacked publication, amidst Jamaica being known for the consumption of sorrel drink.

Keywords: Hibiscus sabdariffa, sorrel, therapeutic attributes, physiological effects, biological systems, anthocyanins.

Graphical Abstract
[1]
Chewonarin, T.; Kinouchi, T.; Kataoka, K.; Arimochi, H.; Kuwahara, T.; Vinitketkumnuen, U.; Ohnishi, Y. Effects of roselle (Hibiscus sabdariffa Linn.), a Thai medicinal plant, on the mutagenicity of various known mutagens in Salmonella typhimurium and on formation of aberrant crypt foci induced by the colon carcinogens azoxymethane and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in F344 rats. Food Chem. Toxicol., 1999, 37(6), 591-601.
[http://dx.doi.org/10.1016/S0278-6915(99)00041-1] [PMID: 10478827]
[2]
Rao, P.U. Nutrient composition and biological evaluation of mesta seed. Plant Foods Hum. Nutr., 1996, 49(1), 27-34.
[http://dx.doi.org/10.1007/BF01092519] [PMID: 9139301]
[3]
Abu-Tarboush, H.M.; Ahmed, S.A.B.; Al Kahtani, H.A. Some nutritional and functional properties of karkade (Hibiscus sabdariffa) seed products. Cereal Chem., 1997, 74(3), 352-355.
[http://dx.doi.org/10.1094/CCHEM.1997.74.3.352]
[4]
Guardiola, S.; Mach, N. Potencial terapéutico del Hibiscus sabdariffa: una revisión de las evidencias científicas. Endocrinol. Nutr., 2014, 61(5), 274-295.
[http://dx.doi.org/10.1016/j.endonu.2013.10.012] [PMID: 24444676]
[5]
El-Shiekh, R.A.; Ashour, R.M.; Abd El-Haleim, E.A.; Ahmed, K.A.; Abdel-Sattar, E. Hibiscus sabdariffa L.: A potent natural neuroprotective agent for the prevention of streptozotocin-induced Alzheimer’s disease in mice. Biomed. Pharmacother., 2020, 128, 110303.
[http://dx.doi.org/10.1016/j.biopha.2020.110303] [PMID: 32480228]
[6]
Adigun, M.O.; Ogundipe, O.D.; Anetor, J.I.; Odetunde, A.O. Dose-dependent changes in some hematological parameters during short-term administration of Hibiscus sabdariffa Calyx aqueous extract (Zobo) in Wistar albino rats. Afr. J. Med. Med. Sci., 2006, 35(1), 73-77.
[PMID: 17209331]
[7]
Singh, P.; Khan, M.; Hailemariam, H. Nutritional and health importance of Hibiscus sabdariffa: A review and indication for research needs. Journal of Nutritional Health & Food Engineering, 2017, 6(5), 125-128.
[http://dx.doi.org/10.15406/jnhfe.2017.06.00212]
[8]
Sáyago-Ayerdi, S.G.; Arranz, S.; Serrano, J.; Goñi, I. Dietary fiber content and associated antioxidant compounds in Roselle flower (Hibiscus sabdariffa L.) beverage. J. Agric. Food Chem., 2007, 55(19), 7886-7890.
[http://dx.doi.org/10.1021/jf070485b] [PMID: 17705439]
[9]
Peng, C.H.; Chyau, C.C.; Chan, K.C.; Chan, T.H.; Wang, C.J.; Huang, C.N. Hibiscus sabdariffa polyphenolic extract inhibits hyperglycemia, hyperlipidemia, and glycation-oxidative stress while improving insulin resistance. J. Agric. Food Chem., 2011, 59(18), 9901-9909.
[http://dx.doi.org/10.1021/jf2022379] [PMID: 21870884]
[10]
Wisetmuen, E.; Pannangpetch, P.; Kongyingyoes, B.; Kukongviriyapan, U.; Yutanawiboonchai, W.; Itharat, A. Insulin secretion enhancing activity of roselle calyx extract in normal and streptozotocin-induced diabetic rats. Pharmacognosy Res., 2013, 5(2), 65-70.
[http://dx.doi.org/10.4103/0974-8490.110520] [PMID: 23798879]
[11]
Yusni, Y.; Meutia, F. Action mechanism of rosella (Hibiscus sabdariffa L.) used to treat metabolic syndrome in elderly women. Evid. Based Complement. Alternat. Med., 2020, 2020, 1-6.
[http://dx.doi.org/10.1155/2020/5351318] [PMID: 33005201]
[12]
Ajiboye, T.O.; Raji, H.O.; Adeleye, A.O.; Adigun, N.S.; Giwa, O.B.; Ojewuyi, O.B.; Oladiji, A.T. Hibiscus sabdariffa calyx palliates insulin resistance, hyperglycemia, dyslipidemia and oxidative rout in fructose-induced metabolic syndrome rats. J. Sci. Food Agric., 2016, 96(5), 1522-1531.
[http://dx.doi.org/10.1002/jsfa.7254] [PMID: 25965053]
[13]
Alshami, I.; Alharbi, A.E. Hibiscus sabdariffa extract inhibits in vitro biofilm formation capacity of Candida albicans isolated from recurrent urinary tract infections. Asian Pac. J. Trop. Biomed., 2014, 4(2), 104-108.
[http://dx.doi.org/10.1016/S2221-1691(14)60217-3] [PMID: 25182280]
[14]
Chiu, C.T.; Chen, J.H.; Chou, F.P.; Lin, H.H. Hibiscus sabdariffa leaf extract inhibits human prostate cancer cell invasion via down-regulation of Akt/NF-kB/MMP-9 pathway. Nutrients, 2015, 7(7), 5065-5087.
[http://dx.doi.org/10.3390/nu7075065] [PMID: 26115086]
[15]
Fakaye, T. Toxicity and immunomodulatory activity of fractions of Hibiscus sabdariffa Linn (family Malvaceae) in animal models. Afr. J. Tradit. Complement. Altern. Med., 2008, 5(4), 394-398.
[http://dx.doi.org/10.4314/ajtcam.v5i4.31296] [PMID: 20161963]
[16]
Hwang, J.M.; Kuo, H.C.; Lin, C.T.; Kao, E.S. Inhibitory effect of liposome-encapsulated anthocyanin on melanogenesis in human melanocytes. Pharm. Biol., 2013, 51(8), 941-947.
[http://dx.doi.org/10.3109/13880209.2013.771376] [PMID: 23570521]
[17]
Mohammed Yusof, N.L.; Zainalabidin, S.; Mohd Fauzi, N.; Budin, S.B. Hibiscus sabdariffa (roselle) polyphenol-rich extract averts cardiac functional and structural abnormalities in type 1 diabetic rats. Appl. Physiol. Nutr. Metab., 2018, 43(12), 1224-1232.
[http://dx.doi.org/10.1139/apnm-2018-0084] [PMID: 29726706]
[18]
Seck, S.M.; Doupa, D.; Dia, D.G.; Diop, E.A.; Ardiet, D.L.; Nogueira, R.C.; Graz, B.; Diouf, B. Clinical efficacy of African traditional medicines in hypertension: A randomized controlled trial with Combretum micranthum and Hibiscus sabdariffa. J. Hum. Hypertens., 2018, 32(1), 75-81.
[http://dx.doi.org/10.1038/s41371-017-0001-6] [PMID: 29311704]
[19]
Seung, T.W.; Park, S.K.; Kang, J.Y.; Kim, J.M.; Park, S.H.; Kwon, B.S.; Lee, C.J.; Kang, J.E.; Kim, D.O.; Lee, U.; Heo, H.J. Ethyl acetate fraction from Hibiscus sabdariffa L. attenuates diabetes-associated cognitive impairment in mice. Food Res. Int., 2018, 105, 589-598.
[http://dx.doi.org/10.1016/j.foodres.2017.11.063] [PMID: 29433251]
[20]
Jiménez-Ferrer, E.; Alarcón-Alonso, J.; Aguilar-Rojas, A.; Zamilpa, A.; Jiménez-Ferrer C, I.; Tortoriello, J.; Herrera-Ruiz, M. Diuretic effect of compounds from Hibiscus sabdariffa by modulation of the aldosterone activity. Planta Med., 2012, 78(18), 1893-1898.
[http://dx.doi.org/10.1055/s-0032-1327864] [PMID: 23150077]
[21]
Fouda, A.M.M.; Daba, M.H.Y.; Dahab, G.M. Inhibitory effects of aqueous extract of Hibiscus sabdariffa on contractility of the rat bladder and uterus. Can. J. Physiol. Pharmacol., 2007, 85(10), 1020-1031.
[http://dx.doi.org/10.1139/Y07-093] [PMID: 18066103]
[22]
Anwar Ibrahim, D.; Noman Albadani, R. Evaluation of the potential nephroprotective and antimicrobial effect of Camellia sinensis leaves versus Hibiscus sabdariffa (in vivo and in vitro studies). Adv. Pharmacol. Sci., 2014, 2014, 1-5.
[http://dx.doi.org/10.1155/2014/389834] [PMID: 24949007]
[23]
Kafeshani, M.; Entezari, M.H.; Karimian, J.; Pourmasoumi, M.; Maracy, M.R.; Amini, M.R.; Hadi, A. A comparative study of the effect of green tea and sour tea on blood pressure and lipid profile in healthy adult men. ARYA Atheroscler., 2017, 13(3), 109-116.
[PMID: 29147120]
[24]
Khuanekkaphan, M.; Noysang, C.; Khobjai, W. Anti-aging potential and phytochemicals of Centella asiatica, Nelumbo nucifera, and Hibiscus sabdariffa extracts. J. Adv. Pharm. Technol. Res., 2020, 11(4), 174-178.
[http://dx.doi.org/10.4103/japtr.JAPTR_79_20] [PMID: 33425700]
[25]
Malacrida, A.; Cavalloro, V.; Martino, E.; Cassetti, A.; Nicolini, G.; Rigolio, R.; Cavaletti, G.; Mannucci, B.; Vasile, F.; Giacomo, M.D.; Collina, S.; Miloso, M. Anti-multiple myeloma potential of secondary metabolites from Hibiscus sabdariffa. Molecules, 2019, 24(13), 2500.
[http://dx.doi.org/10.3390/molecules24132500] [PMID: 31323932]
[26]
Mojiminiyi, F.B.O.; Dikko, M.; Muhammad, B.Y.; Ojobor, P.D.; Ajagbonna, O.P.; Okolo, R.U.; Igbokwe, U.V.; Mojiminiyi, U.E.; Fagbemi, M.A.; Bello, S.O.; Anga, T.J. Antihypertensive effect of an aqueous extract of the calyx of Hibiscus sabdariffa. Fitoterapia, 2007, 78(4), 292-297.
[http://dx.doi.org/10.1016/j.fitote.2007.02.011] [PMID: 17482378]
[27]
Lim, Y.C.; Budin, S.B.; Othman, F.; Latip, J.; Zainalabidin, S. Roselle polyphenols exert potent negative inotropic effects via modulation of intracellular calcium regulatory channels in isolated rat heart. Cardiovasc. Toxicol., 2017, 17(3), 251-259.
[http://dx.doi.org/10.1007/s12012-016-9379-6] [PMID: 27402292]
[28]
Alsayed, A.M.A.; Zhang, B.L.; Bredeloux, P.; Boudesocque-Delaye, L.; Yu, A.; Peineau, N.; Enguehard-Gueiffier, C.; Ahmed, E.M.; Pasqualin, C.; Maupoil, V. Aqueous fraction from Hibiscus sabdariffa relaxes mesenteric arteries of normotensive and hypertensive rats through calcium current reduction and possibly potassium channels modulation. Nutrients, 2020, 12(6), 1782.
[http://dx.doi.org/10.3390/nu12061782] [PMID: 32549326]
[29]
Jalalyazdi, M.; Ghiasi, S.S.; Ramezani, J.; Izadi-Moud, A.; Madani-Sani, F.; Shahlaei, S. Effect of Hibiscus sabdariffa on blood pressure in patients with stage 1 hypertension. J. Adv. Pharm. Technol. Res., 2019, 10(3), 107-111.
[http://dx.doi.org/10.4103/japtr.JAPTR_402_18] [PMID: 31334091]
[30]
Hajifaraji, M.; Matlabi, M.; Ahmadzadeh-Sani, F.; Mehrabi, Y.; Rezaee, M.S.; Hajimehdipour, H.; Hasanzadeh, A.; Roghani, K. Effects of aqueous extracts of dried calyx of sour tea (Hibiscus sabdariffa L.) on polygenic dyslipidemia: A randomized clinical trial. Avicenna J. Phytomed., 2018, 8(1), 24-32.
[PMID: 29387571]
[31]
Al-Anbaki, M.; Nogueira, R.C.; Cavin, A.L.; Al-Hadid, M.; Al-Ajlouni, I.; Shuhaiber, L.; Graz, B. Treating uncontrolled hypertension with Hibiscus sabdariffa when standard treatment is insufficient: Pilot intervention. J. Altern. Complement. Med., 2019, 25(12), 1200-1205.
[http://dx.doi.org/10.1089/acm.2019.0220] [PMID: 31599646]
[32]
Adegunloye, B.J.; Omoniyi, J.O.; Owolabi, O.A.; Ajagbonna, O.P.; Sofola, O.A.; Coker, H.A. Mechanisms of the blood pressure lowering effect of the calyx extract of Hibiscus sabdariffa in rats. Afr. J. Med. Med. Sci., 1996, 25(3), 235-238.
[PMID: 10457797]
[33]
Herrera-Arellano, A.; Miranda-Sánchez, J.; Ávila-Castro, P.; Herrera-Álvarez, S.; Jiménez-Ferrer, J.; Zamilpa, A.; Román-Ramos, R.; Ponce-Monter, H.; Tortoriello, J. Clinical effects produced by a standardized herbal medicinal product of Hibiscus sabdariffa on patients with hypertension. A randomized, double-blind, lisinopril-controlled clinical trial. Planta Med., 2007, 73(1), 6-12.
[http://dx.doi.org/10.1055/s-2006-957065] [PMID: 17315307]
[34]
Abubakar, S.M.; Ukeyima, M.T.; Spencer, J.P.E.; Lovegrove, J.A. Acute effects of Hibiscus sabdariffa calyces on postprandial blood pressure, vascular function, blood lipids, biomarkers of insulin resistance and inflammation in humans. Nutrients, 2019, 11(2), 341.
[http://dx.doi.org/10.3390/nu11020341] [PMID: 30764582]
[35]
Nurfaradilla, S.A.; Saputri, F.C.; Harahap, Y. Effects of Hibiscus sabdariffa calyces aqueous extract on the antihypertensive potency of captopril in the two-kidney-one-clip rat hypertension model. Evid. Based Complement. Alternat. Med., 2019, 2019, 1-7.
[http://dx.doi.org/10.1155/2019/9694212] [PMID: 31379972]
[36]
Si, L.Y.; Ramalingam, A.; Ali, S.S.; Aminuddin, A.; Ng, P.Y.; Latip, J.; Kamisah, Y.; Budin, S.B.; Zainalabidin, S. Roselle attenuates cardiac hypertrophy after myocardial infarction in vivo and in vitro. EXCLI J., 2019, 18, 876-892.
[http://dx.doi.org/10.17179/excli2019-1792] [PMID: 31645847]
[37]
Abdel-Rahman, R.F.; Hessin, A.F.; Abdelbaset, M.; Ogaly, H.A.; Abd-Elsalam, R.M.; Hassan, S.M. Antihypertensive effects of roselle-olive combination in L-NAME-induced hypertensive rats. Oxid. Med. Cell. Longev., 2017, 2017, 1-24.
[http://dx.doi.org/10.1155/2017/9460653] [PMID: 29201276]
[38]
Nwachukwu, D.; Aneke, E.; Obika, L.; Nwachukwu, N. Effects of aqueous extract of Hibiscus sabdariffa on the renin-angiotensin-aldosterone system of Nigerians with mild to moderate essential hypertension: A comparative study with lisinopril. Indian J. Pharmacol., 2015, 47(5), 540-545.
[http://dx.doi.org/10.4103/0253-7613.165194] [PMID: 26600645]
[39]
Soleimani, A.R.; Akbari, H.; Soleimani, S.; Beladi Mousavi, S.S.; Tamadon, M.R. Effect of sour tea (Lipicom) pill versus captopril on the treatment of hypertension. J. Renal Inj. Prev., 2015, 4(3), 73-79.
[http://dx.doi.org/10.12861/jrip.2015.15] [PMID: 26468478]
[40]
Onyenekwe, P.C.; Ajani, E.O.; Ameh, D.A.; Gamaniel, K.S. Antihypertensive effect of roselle (Hibiscus sabdariffa) calyx infusion in spontaneously hypertensive rats and a comparison of its toxicity with that in Wistar rats. Cell Biochem. Funct., 1999, 17(3), 199-206.
[http://dx.doi.org/10.1002/(SICI)1099-0844(199909)17:3<199::AID-CBF829>3.0.CO;2-2] [PMID: 10451541]
[41]
Sabzghabaee, A.; Ataei, E.; Kelishadi, R.; Ghannadi, A.; Soltani, R.; Badri, S.; Shirani, S. Effect of Hibiscus sabdariffa calices on dyslipidemia in obese adolescents: A triple-masked randomized controlled trial. Mater. Sociomed., 2013, 25(2), 76-79.
[http://dx.doi.org/10.5455/msm.2013.25.76-79] [PMID: 24082826]
[42]
McKay, D.L.; Chen, C.Y.O.; Saltzman, E.; Blumberg, J.B. Hibiscus sabdariffa L. tea (tisane) lowers blood pressure in prehypertensive and mildly hypertensive adults. J. Nutr., 2010, 140(2), 298-303.
[http://dx.doi.org/10.3945/jn.109.115097] [PMID: 20018807]
[43]
Mozaffari-Khosravi, H.; Jalali-Khanabadi, B-A.; Afkhami-Ardekani, M.; Fatehi, F.; Noori-Shadkam, M. The effects of sour tea (Hibiscus sabdariffa) on hypertension in patients with type II diabetes. J. Hum. Hypertens., 2009, 23(1), 48-54.
[http://dx.doi.org/10.1038/jhh.2008.100] [PMID: 18685605]
[44]
Pérez-Torres, I.; Torres-Narváez, J.C.; Guarner-Lans, V.; Díaz-Díaz, E.; Perezpeña-Diazconti, M.; Palacios, A.R.; Manzano-Pech, L. Myocardial protection from ischemia-reperfusion damage by the antioxidant effect of Hibiscus sabdariffa Linnaeus on metabolic syndrome subjects. Oxid. Med. Cell. Longev., 2019, 2019, 1-13.
[http://dx.doi.org/10.1155/2019/1724194] [PMID: 31049126]
[45]
Ali, M.B.; Salih, W.M.; Mohamed, A.H.; Homeida, A.M. Investigation of the antispasmodic potential of Hibiscus sabdariffa calyces. J. Ethnopharmacol., 1991, 31(2), 249-257.
[http://dx.doi.org/10.1016/0378-8741(91)90009-3] [PMID: 2023432]
[46]
Ozkol, H.U.; Koyuncu, I.; Tuluce, Y.; Dilsiz, N.; Soral, S.; Ozkol, H. Anthocyanin-rich extract from Hibiscus sabdariffa calyx counteracts UVC-caused impairments in rats. Pharm. Biol., 2015, 53(10), 1435-1441.
[http://dx.doi.org/10.3109/13880209.2014.980586] [PMID: 25784105]
[47]
Li, J.; Lu, Y.R.; Lin, I.F.; Kang, W.; Chen, H.; Lu, H.F.; Wang, H.M.D. Reversing UVB-induced photoaging with Hibiscus sabdariffa calyx aqueous extract. J. Sci. Food Agric., 2020, 100(2), 672-681.
[http://dx.doi.org/10.1002/jsfa.10063] [PMID: 31583701]
[48]
Wang, S.C.; Lee, S.F.; Wang, C.J.; Lee, C.H.; Lee, W.C.; Lee, H.J. Aqueous extract from Hibiscus sabdariffa Linnaeus ameliorate diabetic nephropathy via regulating oxidative status and Akt/Bad/14-3-3γ in an experimental animal model. Evid. Based Complement. Alternat. Med., 2011, 2011, 1-9.
[http://dx.doi.org/10.1093/ecam/nep181] [PMID: 19965962]
[49]
Miranda, C.A.; Schönholzer, T.E.; Mielke, B.B.; dos Santos, D.L.A.; de Souza Almeida, D.; Volpato, G.T.; de Campos, K.E. Insulin response in peripheral tissues in animals chronically treated with aqueous extract of Hibiscus sabdariffa L. Diabetol. Metab. Syndr., 2015, 7(S1)(Suppl. 1), A117.
[http://dx.doi.org/10.1186/1758-5996-7-S1-A117]
[50]
Chou, S.T.; Lo, H.Y.; Li, C.C.; Cheng, L.C.; Chou, P.C.; Lee, Y.C.; Ho, T.Y.; Hsiang, C.Y. Exploring the effect and mechanism of Hibiscus sabdariffa on urinary tract infection and experimental renal inflammation. J. Ethnopharmacol., 2016, 194, 617-625.
[http://dx.doi.org/10.1016/j.jep.2016.10.059] [PMID: 27773797]
[51]
Olatunji, L.A.; Usman, T.O.; Adebayo, J.O.; Olatunji, V.A. Effects of aqueous extract of Hibiscus sabdariffa on renal Na+-K+-ATPase and Ca2+-Mg2+-ATPase activities in Wistar rats. J. Chin. Integr. Med., 2012, 10(9), 1049-1055.
[http://dx.doi.org/10.3736/jcim20120914] [PMID: 22979937]
[52]
Njinga, N.S.; Kola-Mustapha, A.T.; Quadri, A.L.; Atolani, O.; Ayanniyi, R.O.; Buhari, M.O.; Amusa, T.O.; Ajani, E.O.; Folaranmi, O.O.; Bakare-Odunola, M.T.; Kambizi, L.; Oladiji, A.T.; Ebong, P. Toxicity assessment of sub-acute and sub-chronic oral administration and diuretic potential of aqueous extract of Hibiscus sabdariffa calyces. Heliyon, 2020, 6(9), e04853.
[http://dx.doi.org/10.1016/j.heliyon.2020.e04853] [PMID: 33005778]
[53]
Alarcón-Alonso, J.; Zamilpa, A.; Aguilar, F.A.; Herrera-Ruiz, M.; Tortoriello, J.; Jimenez-Ferrer, E. Pharmacological characterization of the diuretic effect of Hibiscus sabdariffa Linn (Malvaceae) extract. J. Ethnopharmacol., 2012, 139(3), 751-756.
[http://dx.doi.org/10.1016/j.jep.2011.12.005] [PMID: 22178178]
[54]
Barletta, C.; Paccone, M.; Uccello, N.; Scaldarella, L.O.; Romano, C.; Mainini, G.; Passaro, M. Efficacy of food supplement Acidif plus® in the treatment of uncomplicated UTIs in women: a pilot observational study. Minerva Ginecol., 2020, 72(2), 70-74.
[http://dx.doi.org/10.23736/S0026-4784.20.04495-0] [PMID: 32403906]
[55]
Fernández-Arroyo, S.; Huete-Toral, F.; de Lara, M.J.P.; de la Luz Cádiz-Gurrea, M.; Legeai-Mallet, L.; Micol, V.; Segura-Carretero, A.; Joven, J.; Pintor, J. The impact of polyphenols on chondrocyte growth and survival: a preliminary report. Food Nutr. Res., 2015, 59(1), 29311.
[http://dx.doi.org/10.3402/fnr.v59.29311] [PMID: 26445212]
[56]
Hadi, A.; Pourmasoumi, M.; Kafeshani, M.; Karimian, J.; Maracy, M.R.; Entezari, M.H. The effect of green tea and sour tea (Hibiscus sabdariffa L.) supplementation on oxidative stress and muscle damage in athletes. J. Diet. Suppl., 2017, 14(3), 346-357.
[http://dx.doi.org/10.1080/19390211.2016.1237400] [PMID: 27736246]
[57]
Umar, I.A.; Maryoms, N.G.; Daikwo, E.; Gidado, A.; Buratai, L.B.; Igbokwe, I.O.; Ibrahim, M.A. The effect of aqueous extracts of Hibiscus sabdariffa (Sorrel) calyces on hematological profile and organ pathological changes in Trypanasoma congolense - infected rats. Afr. J. Tradit. Complement. Altern. Med., 2009, 6(4), 585-591.
[PMID: 20606781]
[58]
Mohamed-Salem, R.; Rodríguez Fernández, C.; Nieto-Pelegrín, E.; Conde-Valentín, B.; Rumbero, A.; Martinez-Quiles, N. Aqueous extract of Hibiscus sabdariffa inhibits pedestal induction by enteropathogenic E. coli and promotes bacterial filamentation in vitro. PLoS One, 2019, 14(3), e0213580.
[http://dx.doi.org/10.1371/journal.pone.0213580] [PMID: 30849110]
[59]
Kao, E.S.; Hsu, J.D.; Wang, C.J.; Yang, S.H.; Cheng, S.Y.; Lee, H.J. Polyphenols extracted from Hibiscus sabdariffa L. inhibited lipopolysaccharide-induced inflammation by improving antioxidative conditions and regulating cyclooxygenase-2 expression. Biosci. Biotechnol. Biochem., 2009, 73(2), 385-390.
[http://dx.doi.org/10.1271/bbb.80639] [PMID: 19202285]
[60]
Strathearn, K.E.; Yousef, G.G.; Grace, M.H.; Roy, S.L.; Tambe, M.A.; Ferruzzi, M.G.; Wu, Q.L.; Simon, J.E.; Lila, M.A.; Rochet, J.C. Neuroprotective effects of anthocyanin- and proanthocyanidin-rich extracts in cellular models of Parkinson׳s disease. Brain Res., 2014, 1555, 60-77.
[http://dx.doi.org/10.1016/j.brainres.2014.01.047] [PMID: 24502982]
[61]
Koch, K.; Weldle, N.; Baier, S.; Büchter, C.; Wätjen, W. Hibiscus sabdariffa L. extract prolongs lifespan and protects against amyloid-β toxicity in Caenorhabditis elegans: involvement of the FoxO and Nrf2 orthologues DAF-16 and SKN-1. Eur. J. Nutr., 2020, 59(1), 137-150.
[http://dx.doi.org/10.1007/s00394-019-01894-w] [PMID: 30710163]
[62]
Suryanti, S.; Partadiredja, G.; Atthobari, J. Red sorrel (Hibiscus sabdariffa) prevents the ethanol-induced deficits of Purkinje cells in the cerebellum. Bratisl. Med. J., 2015, 116(2), 109-114.
[http://dx.doi.org/10.4149/BLL_2015_021] [PMID: 25665477]
[63]
Lorenzana-Martínez, G.; Santerre, A.; Andrade-González, I.; Bañuelos-Pineda, J. Effects of Hibiscus sabdariffa calyces on spatial memory and hippocampal expression of BDNF in ovariectomized rats. Nutr. Neurosci., 2022, 25(4), 670-680.
[http://dx.doi.org/10.1080/1028415X.2020.1804095] [PMID: 32787648]
[64]
Owoeye, O.; Gabriel, M.O. Evaluation of neuroprotective effect of Hibiscus sabdariffa Linn. aqueous extract against ischemic-reperfusion insult by bilateral common carotid artery occlusion in adult male rats. Niger. J. Physiol. Sci., 2017, 32(1), 97-104.
[PMID: 29134984]
[65]
Bayani, G.F.E.; Marpaung, N.L.E.; Simorangkir, D.A.S.; Sianipar, I.R.; Ibrahim, N.; Kartinah, N.T.; Mansur, I.G.; Purba, J.S.; Ilyas, E.I.I. Anti-inflammatory effects of Hibiscus sabdariffa linn. on the IL-1β/IL-1ra ratio in plasma and hippocampus of overtrained subjects and correlation with spatial memory. Kobe J. Med. Sci., 2018, 64(2), E73-E83.
[PMID: 30381729]
[66]
Adenkola, A.Y.; Oluremi, O.I. Erythrocyte osmotic fragility and excitability score in rabbit fed Hibiscus sabdariffa in graded level. Niger. J. Physiol. Sci., 2014, 29(2), 113-117.
[PMID: 26196576]
[67]
Oyewopo, A.O.; Olaniyi, K.S.; Olojede, S.O.; Lawal, S.K.; Amusa, O.A.; Ajadi, I.O. Hibiscus sabdariffa extract protects against cadmium-induced ovarian toxicity in adult Wistar rats. Int. J. Physiol. Pathophysiol. Pharmacol., 2020, 12(4), 107-114.
[PMID: 32934766]
[68]
de Arruda, A.; Cardoso, C.A.L.; Vieira, M.C.; Arena, A.C. Safety assessment of Hibiscus sabdariffa after maternal exposure on male reproductive parameters in rats. Drug Chem. Toxicol., 2016, 39(1), 22-27.
[http://dx.doi.org/10.3109/01480545.2014.1003938] [PMID: 25682722]
[69]
Fakeye, T.O.; Pal, A.; Bawankule, D.U.; Khanuja, S.P.S. Immunomodulatory effect of extracts ofHibiscus sabdariffa L. (Family Malvaceae) in a mouse model. Phytother. Res., 2008, 22(5), 664-668.
[http://dx.doi.org/10.1002/ptr.2370] [PMID: 18398929]
[70]
Ibrahim, K.G.; Lembede, B.W.; Chivandi, E.; Erlwanger, K. Erythrocyte osmotic fragility and general health status of adolescent Sprague Dawley rats supplemented with Hibiscus sabdariffa aqueous calyx extracts as neonates followed by a high-fructose diet post-weaning. J. Anim. Physiol. Anim. Nutr., 2018, 102(1), 114-121.
[http://dx.doi.org/10.1111/jpn.12665] [PMID: 28299849]
[71]
Lubis, M.; Siregar, G.A.; Bangun, H.; Ilyas, S. The effect of roselle flower petals extract (Hibiscus sabdariffa Linn.) on reducing inflammation in dextran sodium sulfate-induced colitis. Med. Glas., 2020, 17(2), 395-401.
[http://dx.doi.org/10.17392/1095-20] [PMID: 32329325]
[72]
Beltrán-Debón, R.; Alonso-Villaverde, C.; Aragonès, G.; Rodríguez-Medina, I.; Rull, A.; Micol, V.; Segura-Carretero, A.; Fernández-Gutiérrez, A.; Camps, J.; Joven, J. The aqueous extract of Hibiscus sabdariffa calices modulates the production of monocyte chemoattractant protein-1 in humans. Phytomedicine, 2010, 17(3-4), 186-191.
[http://dx.doi.org/10.1016/j.phymed.2009.08.006] [PMID: 19765963]
[73]
Sogo, T.; Terahara, N.; Hisanaga, A.; Kumamoto, T.; Yamashiro, T.; Wu, S.; Sakao, K.; Hou, D.X. Anti-inflammatory activity and molecular mechanism of delphinidin 3-sambubioside, a Hibiscus anthocyanin. Biofactors, 2015, 41(1), 58-65.
[http://dx.doi.org/10.1002/biof.1201] [PMID: 25728636]
[74]
Yang, E.K.; Spence, L.R.; Harding, R.Y.; Moore, B.P.A. A “new” lectin for detection of T, Tn, and Th polyagglutination. Transfusion, 1982, 22(4), 338-339.
[http://dx.doi.org/10.1046/j.1537-2995.1982.22482251225.x] [PMID: 7101429]
[75]
Semsri, S.; Seatew, C.; Rattanabunyong, S.; Ruekit, S.; Horata, N.; Panya, A.; Yenchitsomanus, P.T.; Sawatdichaikul, O.; Choowongkomon, K. In vitro studies of anti-EGFR tyrosine kinase activity of Thai nutraceutical plants. Iran. J. Pharm. Res., 2020, 19(2), 199-206.
[http://dx.doi.org/10.22037/ijpr.2017.2022] [PMID: 33224225]
[76]
Malacrida, A.; Maggioni, D.; Cassetti, A.; Nicolini, G.; Cavaletti, G.; Miloso, M. Antitumoral effect of Hibiscus sabdariffa on human squamous cell carcinoma and multiple myeloma cells. Nutr. Cancer, 2016, 68(7), 1161-1170.
[http://dx.doi.org/10.1080/01635581.2016.1208830] [PMID: 27618152]
[77]
Mojiminiyi, F.B.; Audu, Z.; Etuk, E.U.; Ajagbonna, O.P. Attenuation of salt-induced hypertension by aqueous calyx extract of Hibiscus sabdariffa. Niger. J. Physiol. Sci., 2012, 27(2), 195-200.
[PMID: 23652235]
[78]
Aliyu, B.; Oyeniyi, Y.J.; Mojiminiyi, F.B.; Isezuo, S.A.; Alada, A.R. The aqueous calyx extract of Hibiscus sabdariffa lowers blood pressure and heart rate via sympathetic nervous system dependent mechanisms. Niger. J. Physiol. Sci., 2014, 29(2), 131-136.
[PMID: 26196579]
[79]
Odigie, I.P.; Ettarh, R.R.; Adigun, S.A. Chronic administration of aqueous extract of Hibiscus sabdariffa attenuates hypertension and reverses cardiac hypertrophy in 2K-1C hypertensive rats. J. Ethnopharmacol., 2003, 86(2-3), 181-185.
[http://dx.doi.org/10.1016/S0378-8741(03)00078-3] [PMID: 12738084]
[80]
Haji Faraji, M.; Haji Tarkhani, A.H. The effect of sour tea (Hibiscus sabdariffa) on essential hypertension. J. Ethnopharmacol., 1999, 65(3), 231-236.
[http://dx.doi.org/10.1016/S0378-8741(98)00157-3] [PMID: 10404421]
[81]
Inuwa, I.; Ali, B.H.; Al-Lawati, I.; Beegam, S.; Ziada, A.; Blunden, G. Long-term ingestion of Hibiscus sabdariffa calyx extract enhances myocardial capillarization in the spontaneously hypertensive rat. Exp. Biol. Med. (Maywood), 2012, 237(5), 563-569.
[http://dx.doi.org/10.1258/ebm.2012.011357] [PMID: 22678012]
[82]
Idris, M.H.; Budin, S.B.; Osman, M.; Mohamed, J. Protective role of Hibiscus sabdariffa calyx extract against streptozotocin induced sperm damage in diabetic rats. EXCLI J., 2012, 11, 659-669.
[PMID: 27847454]
[83]
Kartinah, N.T.; Fadilah, F.; Ibrahim, E.I.; Suryati, Y. The potential of Hibiscus sabdariffa Linn in inducing glucagon-like peptide-1 via SGLT-1 and GLPR in DM subjects. BioMed Res. Int., 2019, 2019, 1-8.
[http://dx.doi.org/10.1155/2019/8724824] [PMID: 31828140]
[84]
Adeyemi, D.O.; Ukwenya, V.O.; Obuotor, E.M.; Adewole, S.O. Anti-hepatotoxic activities of Hibiscus sabdariffa L. in animal model of streptozotocin diabetes-induced liver damage. BMC Complement. Altern. Med., 2014, 14(1), 277.
[http://dx.doi.org/10.1186/1472-6882-14-277] [PMID: 25077880]
[85]
Fakeye, T.O.; Pal, A.; Bawankule, D.U.; Yadav, N.P.; Khanuja, S.P.S. Toxic effects of oral administration of extracts of dried calyx of Hibiscus sabdariffa Linn. (Malvaceae). Phytother. Res., 2009, 23(3), 412-416.
[http://dx.doi.org/10.1002/ptr.2644] [PMID: 19003943]
[86]
Sireeratawong, S.; Itharat, A.; Khonsung, P.; Lertprasertsuke, N.; Jaijoy, K. Toxicity studies of the water extract from the calyces of Hibiscus sabdariffa L. in rats. Afr. J. Tradit. Complement. Altern. Med., 2013, 10(4), 122-127.
[http://dx.doi.org/10.4314/ajtcam.v10i4.20] [PMID: 24146512]
[87]
Hassan, S.; Švajdlenka, E. Biological evaluation and molecular docking of protocatechuic acid from Hibiscus sabdariffa L. as a potent urease inhibitor by an ESI-MS based method. Molecules, 2017, 22(10), 1696.
[http://dx.doi.org/10.3390/molecules22101696] [PMID: 29019930]
[88]
Akindahunsi, A.A.; Olaleye, M.T. Toxicological investigation of aqueous-methanolic extract of the calyces of Hibiscus sabdariffa L. J. Ethnopharmacol., 2003, 89(1), 161-164.
[http://dx.doi.org/10.1016/S0378-8741(03)00276-9] [PMID: 14522449]
[89]
Tseng, T.H.; Kao, E.S.; Chu, C.Y.; Chou, F.P.; Lin Wu, H.W.; Wang, C.J. Protective effects of dried flower extracts of Hibiscus sabdariffa L. against oxidative stress in rat primary hepatocytes. Food Chem. Toxicol., 1997, 35(12), 1159-1164.
[http://dx.doi.org/10.1016/S0278-6915(97)85468-3] [PMID: 9449221]
[90]
Tseng, T.H.; Kao, T.W.; Chu, C.Y.; Chou, F.P.; Lin, W.L.; Wang, C.J. Induction of apoptosis by Hibiscus protocatechuic acid in human leukemia cells via reduction of retinoblastoma (RB) phosphorylation and Bcl-2 expression. Biochem. Pharmacol., 2000, 60(3), 307-315.
[http://dx.doi.org/10.1016/S0006-2952(00)00322-1] [PMID: 10856425]
[91]
Wang, CJ; Wang, JM; Lin, WL; Chu, CY; Chou, FP; Tseng, TH Protective effect of Hibiscus anthocyanins against tert-butyl hydroperoxide-induced hepatic toxicity in rats. Food Chem Toxicol: An International Journal published for the British Industrial Biological Research Association, 2000, 38(5), 411-416.
[http://dx.doi.org/10.1016/S0278-6915(00)00011-9]
[92]
Mohamed, B.B.; Aftab, B.; Sarwar, M.B.; Rashid, B.; Ahmad, Z.; Hassan, S.; Husnain, T. Identification and characterization of the diverse stress-responsive R2R3-RMYB transcription factor from Hibiscus sabdariffa L. Int. J. Genomics, 2017, 2017, 1-12.
[http://dx.doi.org/10.1155/2017/2763259] [PMID: 29181384]
[93]
Goswami, M.; Das, A.M. Synthesis of cellulose impregnated copper nanoparticles as an efficient heterogeneous catalyst for C N coupling reactions under mild conditions. Carbohydr. Polym., 2018, 195, 189-198.
[http://dx.doi.org/10.1016/j.carbpol.2018.04.033] [PMID: 29804968]
[94]
Nath, A.; Joshi, S.R. Ultrastructural effect on mastitis pathogens by extract of endophytic fungi associated with ethnoveterinary plant, Hibiscus sabdariffa L. J. Microsc. Ultrastruct., 2015, 3(1), 38-43.
[http://dx.doi.org/10.1016/j.jmau.2014.10.001] [PMID: 30023180]
[95]
Williams, M.; Asemota, H.N.; Williams, E.; McGrowder, D.; Nwokocha, C. The effect of a combination treatment of biomagnetic therapy and a low glycemic influenced diet on nonfasting blood glucose levels in type 2 diabetic rats. Diabetes Manag., 2018, 8, 74-81.
[96]
Nyam, K.L.; Leao, S.Y.; Tan, C.P.; Long, K. Functional properties of roselle (Hibiscus sabdariffa L.) seed and its application as bakery product. J. Food Sci. Technol., 2014, 51(12), 3830-3837.
[http://dx.doi.org/10.1007/s13197-012-0902-x] [PMID: 25477650]
[97]
Le, B.A.; Okitsu, K.; Imamura, K.; Takenaka, N.; Maeda, Y. Ultrasound assisted cascade extraction of oil, vitamin E, and saccharides from roselle (Hibiscus sabdariffa L.) seeds. Anal. Sci., 2020, 36(9), 1091-1097.
[http://dx.doi.org/10.2116/analsci.20P073] [PMID: 32336730]
[98]
Olika Keyata, E.; Tola, Y.B.; Bultosa, G.; Fikreyesus Forsido, S. Proximate, mineral, and anti-nutrient compositions of underutilized plants of Ethiopia: Figl (Raphanus sativus L.), Girgir (Eruca sativa L) and Karkade (Hibiscus sabdariffa): Implications for in vitro mineral bioavailability. Food Res. Int., 2020, 137, 109724.
[http://dx.doi.org/10.1016/j.foodres.2020.109724] [PMID: 33233293]

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