A Multimodal Ultrasound Observation Study on the Effect of Vitamin D on Uterine Fibroids in Non-menopausal Women

Title:A Multimodal Ultrasound Observation Study on the Effect of Vitamin D on Uterine Fibroids in Non-menopausal Women

Volume: 20

Author(s): Qi Wang, Peng Tian, Wei Sun, Xin Liu, Xiuhua Yang*Zhiwei Yang

Affiliation:

• Department of Abdominal Ultrasound, The First Affiliated Hospital of Harbin Medical University, No.23 Youzheng Street, Nangang District, Harbin 150000, Heilongjiang Province, China

Keywords: Multimodal ultrasound, Vitamin D, Uterine fibroids, Elastic strain ratio, Blood flow grade, Pre-menopausal women.

Abstract:

Introduction: It has been reported in the literature that Vitamin D can inhibit the growth of uterine fibroids, but the evaluation index is only the size of the uterine fibroids. The purpose of this study was to evaluate the effect of vitamin D on the size, hardness, and blood flow of uterine fibroids in premenopausal women by multimodal ultrasound.

Methods: A total of 64 pre-menopausal women with uterine fibroids complicated vitamin D deficiency were enrolled in this study and randomly divided into two groups: the vitamin D group (n=32) which received oral vitamin D (1600 IU/ day) and the control group (n=32) without vitamin D supplementation. After three months of intervention, the mean diameter of uterine fibroids, elastic strain ratio, and blood flow grade were evaluated by multimodal ultrasound, and the clinical symptoms of the two groups were evaluated by questionnaire.

Results: The vitamin D group reported a significant increment in the serum 25-hydroxyvitamin D (P < 0.001). In addition, there were significant reductions in the mean diameter, and elastic strain ratio of uterine fibroids (P =.043 and P =.038, respectively), but no significant difference in the blood flow grade of uterine fibroids was observed (P =.272). Compared with the control group, the vitamin D group achieved significant relief in dysmenorrhea and frequent urination, as well as improvement in heavy menstrual bleeding.

Conclusion: The application of multimodal ultrasound provides a more comprehensive theoretical basis for vitamin on uterine fibroids. Vitamin D can effectively reduce the size of uterine fibroids in pre-menopausal women and relieve their symptoms. It is highly likely to be a promising, safe, effective, and inexpensive drug for uterine fibroids, which has good application value and promotion prospects.

Cite this article as:

Wang Qi, Tian Peng, Sun Wei, Liu Xin, Yang Xiuhua*, Yang Zhiwei, A Multimodal Ultrasound Observation Study on the Effect of Vitamin D on Uterine Fibroids in Non-menopausal Women, Current Medical Imaging 2024; 20 : e15734056281479 . https://dx.doi.org/10.2174/0115734056281479231030053817