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当代阿耳茨海默病研究

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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Review Article

阿尔茨海默病、轻度认知障碍和主观记忆主诉的常见神经精神症状：一个统一的框架

卷 20, 期 7, 2023

发表于: 23 October, 2023

页: [459 - 470] 页: 12

弟呕挨: 10.2174/0115672050255489231012072014

价格: $65

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摘要

阿尔茨海默病（AD）连续体是一种独特的认知障碍，通常包括主观记忆主诉（SMC）、轻度认知障碍（MCI）和AD痴呆等阶段。神经精神症状（NPS），如冷漠、焦虑、压力和抑郁，在整个AD连续体中非常常见。然而，关于这些NPS如何在AD连续体中变化，尤其是SMC，有大量的研究。由于特定NPS与其他NPS的共线性、认知能力下降和环境因素（如压力），对于特定NPS对AD连续体每个阶段的影响也存在分歧。在这篇文章中，我们对科学文献进行了一次新颖的视角回顾，以了解NPS在AD连续体中的存在。具体而言，我们回顾了冷漠、抑郁、焦虑和压力在AD、MCI和SMC中的影响。然后，我们在这一知识的基础上，提出了两种在AD连续体中NPS发生的理论。因此，我们强调了当前的形势、局限性（例如，不同的操作）以及围绕NPS文献的争论。我们还概述了可以澄清争论并启发未来NPS研究的理论。

关键词: 神经精神症状（NPS）、阿尔茨海默病（AD）、轻度认知障碍（MCI）、主观记忆障碍（SMC）、压力、痴呆、抑郁。

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[1]
Bruen, P.D.; McGeown, W.J.; Shanks, M.F.; Venneri, A. Neuroanatomical correlates of neuropsychiatric symptoms in Alzheimer’s disease. Brain, 2008, 131(9), 2455-2463.
[http://dx.doi.org/10.1093/brain/awn151] [PMID: 18669506]
[2]
Mendez, M.F. The relationship between anxiety and Alzheimer’s Disease1. J. Alzheimers Dis. Rep., 2021, 5(1), 171-177.
[http://dx.doi.org/10.3233/ADR-210294] [PMID: 33981954]
[3]
Cummings, J.L.; Mega, M.; Gray, K.; Rosenberg-Thompson, S.; Carusi, D.A.; Gornbein, J. The neuropsychiatric inventory: Comprehensive assessment of psychopathology in dementia. Neurology, 1994, 44(12), 2308-2314.
[http://dx.doi.org/10.1212/WNL.44.12.2308] [PMID: 7991117]
[4]
Jaroudi, W.; Garami, J.; Garrido, S.; Hornberger, M.; Keri, S.; Moustafa, A.A. Factors underlying cognitive decline in old age and Alzheimer’s disease: The role of the hippocampus. Rev. Neurosci., 2017, 28(7), 705-714.
[http://dx.doi.org/10.1515/revneuro-2016-0086] [PMID: 28422707]
[5]
Lanctôt, K.L.; Amatniek, J.; Ancoli-Israel, S.; Arnold, S.E.; Ballard, C.; Cohen-Mansfield, J.; Ismail, Z.; Lyketsos, C.; Miller, D.S.; Musiek, E.; Osorio, R.S.; Rosenberg, P.B.; Satlin, A.; Steffens, D.; Tariot, P.; Bain, L.J.; Carrillo, M.C.; Hendrix, J.A.; Jurgens, H.; Boot, B. Neuropsychiatric signs and symptoms of Alzheimer’s disease: New treatment paradigms. Alzheimers Dement., 2017, 3(3), 440-449.
[http://dx.doi.org/10.1016/j.trci.2017.07.001] [PMID: 29067350]
[6]
Lyketsos, C.G.; Carrillo, M.C.; Ryan, J.M.; Khachaturian, A.S.; Trzepacz, P.; Amatniek, J.; Cedarbaum, J.; Brashear, R.; Miller, D.S. Neuropsychiatric symptoms in Alzheimer’s disease. Alzheimers Dement., 2011, 7(5), 532-539.
[http://dx.doi.org/10.1016/j.jalz.2011.05.2410] [PMID: 21889116]
[7]
Bensamoun, D.; Guignard, R.; Furst, A.J.; Derreumaux, A.; Manera, V.; Darcourt, J.; Benoit, M.; Robert, P.H.; David, R. Associations between neuropsychiatric symptoms and cerebral amyloid deposition in cognitively impaired elderly people. J. Alzheimers Dis., 2015, 49(2), 387-398.
[http://dx.doi.org/10.3233/JAD-150181] [PMID: 26484900]
[8]
Cassidy, C.M.; Therriault, J.; Pascoal, T.A.; Cheung, V.; Savard, M.; Tuominen, L.; Chamoun, M.; McCall, A.; Celebi, S.; Lussier, F.; Massarweh, G.; Soucy, J.P.; Weinshenker, D.; Tardif, C.; Ismail, Z.; Gauthier, S.; Rosa-Neto, P. Association of locus coeruleus integrity with Braak stage and neuropsychiatric symptom severity in Alzheimer’s disease. Neuropsychopharmacology, 2022, 47(5), 1128-1136.
[http://dx.doi.org/10.1038/s41386-022-01293-6] [PMID: 35177805]
[9]
Chen, Y.; Dang, M.; Zhang, Z. Brain mechanisms underlying neuropsychiatric symptoms in Alzheimer’s disease: A systematic review of symptom-general and –specific lesion patterns. Mol. Neurodegener., 2021, 16(1), 38.
[http://dx.doi.org/10.1186/s13024-021-00456-1] [PMID: 34099005]
[10]
Mroczek, M.; Clark, C.; Dayon, L.; Bowman, G.L.; Popp, J. Cerebrospinal fluid proteome alterations associated with neuropsychiatric symptoms in cognitive decline and alzheimer’s disease. Cells, 2022, 11(6), 1030.
[http://dx.doi.org/10.3390/cells11061030] [PMID: 35326481]
[11]
Veitch, D.P.; Weiner, M.W.; Aisen, P.S.; Beckett, L.A.; Cairns, N.J.; Green, R.C.; Harvey, D.; Jack, C.R., Jr; Jagust, W.; Morris, J.C.; Petersen, R.C.; Saykin, A.J.; Shaw, L.M.; Toga, A.W.; Trojanowski, J.Q. Understanding disease progression and improving Alzheimer’s disease clinical trials: Recent highlights from the Alzheimer’s Disease Neuroimaging Initiative. Alzheimers Dement., 2019, 15(1), 106-152.
[http://dx.doi.org/10.1016/j.jalz.2018.08.005] [PMID: 30321505]
[12]
American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 5th ed; American Psychiatric Publishing: Washington, D.C, 2013.
[13]
Taragano, F.E.; Allegri, R.F.; Heisecke, S.L.; Martelli, M.I.; Feldman, M.L.; Sánchez, V.; García, V.A.; Tufro, G.; Castro, D.M.; Leguizamón, P.P.; Guelar, V.; Ruotolo, E.; Zegarra, C.; Dillon, C. Risk of conversion to dementia in a mild behavioral impairment group compared to a psychiatric group and to a mild cognitive impairment group. J. Alzheimers Dis., 2018, 62(1), 227-238.
[http://dx.doi.org/10.3233/JAD-170632] [PMID: 29439333]
[14]
Ma, L. Depression, anxiety, and apathy in mild cognitive impairment: Current perspectives. Front. Aging Neurosci., 2020, 12, 9.
[http://dx.doi.org/10.3389/fnagi.2020.00009] [PMID: 32082139]
[15]
Palmer, K.; Di Iulio, F.; Varsi, A.E.; Gianni, W.; Sancesario, G.; Caltagirone, C.; Spalletta, G. Neuropsychiatric predictors of progression from amnestic-mild cognitive impairment to Alzheimer’s disease: The role of depression and apathy. J. Alzheimers Dis., 2010, 20(1), 175-183.
[http://dx.doi.org/10.3233/JAD-2010-1352] [PMID: 20164594]
[16]
Brigola, A.G.; Manzini, C.S.S.; Oliveira, G.B.S.; Ottaviani, A.C.; Sako, M.P.; Vale, F.A.C. Subjective memory complaints associated with depression and cognitive impairment in the elderly: A systematic review. Dement. Neuropsychol., 2015, 9(1), 51-57.
[http://dx.doi.org/10.1590/S1980-57642015DN91000009] [PMID: 29213941]
[17]
Warren, S.L.; Reid, E.; Whitfield, P.; Moustafa, A.A. Subjective memory complaints as a predictor of mild cognitive impairment and Alzheimer’s disease. Discover Psychology, 2022, 2(1), 13.
[http://dx.doi.org/10.1007/s44202-022-00031-9]
[18]
Boutoleau-Bretonnière, C.; Pouclet-Courtemanche, H.; Gillet, A.; Bernard, A.; Deruet, A.L.; Gouraud, I.; Mazoue, A.; Lamy, E.; Rocher, L.; Kapogiannis, D.; El Haj, M. The effects of confinement on neuropsychiatric symptoms in Alzheimer’s disease during the COVID-19 crisis. J. Alzheimers Dis., 2020, 76(1), 41-47.
[http://dx.doi.org/10.3233/JAD-200604] [PMID: 32568211]
[19]
Yates, J.A.; Clare, L.; Woods, R.T. Subjective memory complaints, mood and MCI: A follow-up study. Aging Ment. Health, 2017, 21(3), 313-321.
[http://dx.doi.org/10.1080/13607863.2015.1081150] [PMID: 26329364]
[20]
Geda, Y.E.; Schneider, L.S.; Gitlin, L.N.; Miller, D.S.; Smith, G.S.; Bell, J.; Evans, J.; Lee, M.; Porsteinsson, A.; Lanctôt, K.L.; Rosenberg, P.B.; Sultzer, D.L.; Francis, P.T.; Brodaty, H.; Padala, P.P.; Onyike, C.U.; Ortiz, L.A.; Ancoli-Israel, S.; Bliwise, D.L.; Martin, J.L.; Vitiello, M.V.; Yaffe, K.; Zee, P.C.; Herrmann, N.; Sweet, R.A.; Ballard, C.; Khin, N.A.; Alfaro, C.; Murray, P.S.; Schultz, S.; Lyketsos, C.G. Neuropsychiatric symptoms in Alzheimer’s disease: Past progress and anticipation of the future. Alzheimers Dement., 2013, 9(5), 602-608.
[http://dx.doi.org/10.1016/j.jalz.2012.12.001] [PMID: 23562430]
[21]
Van Dam, D.; Vermeiren, Y.; Dekker, A.D.; Naudé, P.J.; Deyn, P.P. Neuropsychiatric disturbances in Alzheimer’s disease: What have we learned from neuropathological studies? Curr. Alzheimer Res., 2016, 13(10), 1145-1164.
[http://dx.doi.org/10.2174/1567205013666160502123607] [PMID: 27137218]
[22]
Wolinsky, D.; Drake, K.; Bostwick, J. Diagnosis and management of neuropsychiatric symptoms in Alzheimer’s disease. Curr. Psychiatry Rep., 2018, 20(12), 117.
[http://dx.doi.org/10.1007/s11920-018-0978-8] [PMID: 30367272]
[23]
Lanza, S.T.; Flaherty, B.P.; Collins, L.M. Latent class and latent transition analysis.Handbook of psychology: Research methods in psychology; John Wiley & Sons, Inc.: Hoboken, NJ, US, 2003, Vol. 2, pp. 663-685.
[http://dx.doi.org/10.1002/0471264385.wei0226]
[24]
Mehak, S.F.; Shivakumar, A.B.; Saraf, V.; Johansson, M.; Gangadharan, G. Apathy in Alzheimer’s disease: A neurocircuitry based perspective. Ageing Res. Rev., 2023, 87, 101891.
[http://dx.doi.org/10.1016/j.arr.2023.101891] [PMID: 36871779]
[25]
Mortby, M.E.; Adler, L.; Agüera-Ortiz, L.; Bateman, D.R.; Brodaty, H.; Cantillon, M.; Geda, Y.E.; Ismail, Z.; Lanctôt, K.L.; Marshall, G.A.; Padala, P.R.; Politis, A.; Rosenberg, P.B.; Siarkos, K.; Sultzer, D.L.; Theleritis, C. Apathy as a treatment target in alzheimer’s disease: Implications for clinical trials. Am. J. Geriatr. Psychiatry, 2022, 30(2), 119-147.
[http://dx.doi.org/10.1016/j.jagp.2021.06.016] [PMID: 34315645]
[26]
Richard, E.; Schmand, B.; Eikelenboom, P.; Yang, S.C.; Ligthart, S.A.; Moll van Charante, E.P.; van Gool, W.A. Symptoms of apathy are associated with progression from mild cognitive impairment to Alzheimer’s disease in non-depressed subjects. Dement. Geriatr. Cogn. Disord., 2012, 33(2-3), 204-209.
[http://dx.doi.org/10.1159/000338239] [PMID: 22722671]
[27]
Robert, P.; Onyike, C.U.; Leentjens, A.F.G.; Dujardin, K.; Aalten, P.; Starkstein, S.; Verhey, F.R.J.; Yessavage, J.; Clement, J.P.; Drapier, D.; Bayle, F.; Benoit, M.; Boyer, P.; Lorca, P.M.; Thibaut, F.; Gauthier, S.; Grossberg, G.; Vellas, B.; Byrne, J. Proposed diagnostic criteria for apathy in Alzheimer’s disease and other neuropsychiatric disorders. Eur. Psychiatry, 2009, 24(2), 98-104.
[http://dx.doi.org/10.1016/j.eurpsy.2008.09.001] [PMID: 19201579]
[28]
Nobis, L.; Husain, M. Apathy in Alzheimer’s disease. Curr. Opin. Behav. Sci., 2018, 22, 7-13.
[http://dx.doi.org/10.1016/j.cobeha.2017.12.007] [PMID: 30123816]
[29]
Zhang, M.; Wang, H.; Li, T.; Yu, X. Prevalence of neuropsychiatric symptoms across the declining memory continuum: An observational study in a memory clinic setting. Dement. Geriatr. Cogn. Disord. Extra, 2012, 2(1), 200-208.
[http://dx.doi.org/10.1159/000338410] [PMID: 22719746]
[30]
Teixeira, A.L.; Gonzales, M.M.; de Souza, L.C.; Weisenbach, S.L. Revisiting apathy in Alzheimer’s Disease: From conceptualization to therapeutic approaches. Behav. Neurol., 2021, 2021, 1-8.
[http://dx.doi.org/10.1155/2021/6319826] [PMID: 34394772]
[31]
Landes, A.M.; Sperry, S.D.; Strauss, M.E.; Geldmacher, D.S. Apathy in Alzheimer’s disease. J. Am. Geriatr. Soc., 2001, 49(12), 1700-1707.
[http://dx.doi.org/10.1046/j.1532-5415.2001.49282.x] [PMID: 11844006]
[32]
Robert, P.H.; Berr, C.; Volteau, M.; Bertogliati, C.; Benoit, M.; Mahieux, F.; Legrain, S.; Dubois, B. Neuropsychological performance in mild cognitive impairment with and without apathy. Dement. Geriatr. Cogn. Disord., 2006, 21(3), 192-197.
[http://dx.doi.org/10.1159/000090766] [PMID: 16424666]
[33]
Zhao, J.; Jin, X.; Chen, B.; Fu, C.; Ji, S.; Shen, W.; Wei, J.; Zheng, H.; Zhang, Y. Apathy symptoms increase the risk of dementia conversion: a case‐matching cohort study on patients with post‐stroke mild cognitive impairment in CHINA. Psychogeriatrics, 2021, 21(2), 149-157.
[http://dx.doi.org/10.1111/psyg.12634] [PMID: 33395732]
[34]
Duara, R.; Loewenstein, D.A.; Potter, E.; Barker, W.; Raj, A.; Schoenberg, M.; Wu, Y.; Banko, J.; Potter, H.; Greig, M.T.; Schinka, J.; Borenstein, A. Pre-MCI and MCI: Neuropsychological, clinical, and imaging features and progression rates. Am. J. Geriatr. Psychiatry, 2011, 19(11), 951-960.
[http://dx.doi.org/10.1097/JGP.0b013e3182107c69] [PMID: 21422909]
[35]
Martin, E.; Velayudhan, L. Neuropsychiatric symptoms in mild cognitive impairment: A literature review. Dement. Geriatr. Cogn. Disord., 2020, 49(2), 146-155.
[http://dx.doi.org/10.1159/000507078] [PMID: 32289790]
[36]
Hwang, T.J.; Masterman, D.L.; Ortiz, F.; Fairbanks, L.A.; Cummings, J.L. Mild cognitive impairment is associated with characteristic neuropsychiatric symptoms. Alzheimer Dis. Assoc. Disord., 2004, 18(1), 17-21.
[http://dx.doi.org/10.1097/00002093-200401000-00004] [PMID: 15195459]
[37]
Ruthirakuhan, M.; Herrmann, N.; Vieira, D.; Gallagher, D.; Lanctôt, K.L. The roles of apathy and depression in predicting alzheimer disease: A longitudinal analysis in older adults with mild cognitive impairment. Am. J. Geriatr. Psychiatry, 2019, 27(8), 873-882.
[http://dx.doi.org/10.1016/j.jagp.2019.02.003] [PMID: 30910421]
[38]
Elfgren, C.; Gustafson, L.; Vestberg, S.; Passant, U. Subjective memory complaints, neuropsychological performance and psychiatric variables in memory clinic attendees: A 3-year follow-up study. Arch. Gerontol. Geriatr., 2010, 51(3), e110-e114.
[http://dx.doi.org/10.1016/j.archger.2010.02.009] [PMID: 20211500]
[39]
Kawagoe, T.; Onoda, K.; Yamaguchi, S. Subjective memory complaints are associated with altered resting-state functional connectivity but not structural atrophy. Neuroimage Clin., 2019, 21, 101675.
[http://dx.doi.org/10.1016/j.nicl.2019.101675] [PMID: 30642761]
[40]
Guercio, B.J.; Donovan, N.J.; Munro, C.E.; Aghjayan, S.L.; Wigman, S.E.; Locascio, J.J.; Amariglio, R.E.; Rentz, D.M.; Johnson, K.A.; Sperling, R.A.; Marshall, G.A. The apathy evaluation scale: A comparison of subject, informant, and clinician report in cognitively normal elderly and mild cognitive impairment. J. Alzheimers Dis., 2015, 47(2), 421-432.
[http://dx.doi.org/10.3233/JAD-150146] [PMID: 26401564]
[41]
Johansson, M.; Stomrud, E.; Lindberg, O.; Westman, E.; Johansson, P.M.; van Westen, D.; Mattsson, N.; Hansson, O. Apathy and anxiety are early markers of Alzheimer’s disease. Neurobiol. Aging, 2020, 85, 74-82.
[http://dx.doi.org/10.1016/j.neurobiolaging.2019.10.008] [PMID: 31735378]
[42]
Finger, E.; Zhang, J.; Dickerson, B.; Bureau, Y.; Masellis, M. Disinhibition in Alzheimer’s disease is associated with reduced right frontal pole cortical thickness. J. Alzheimers Dis., 2017, 60(3), 1161-1170.
[http://dx.doi.org/10.3233/JAD-170348] [PMID: 28984590]
[43]
Huey, E.D.; Lee, S.; Cheran, G.; Grafman, J.; Devanand, D.P. Brain regions involved in arousal and reward processing are associated with apathy in alzheimer’s disease and frontotemporal dementia. J. Alzheimers Dis., 2016, 55(2), 551-558.
[http://dx.doi.org/10.3233/JAD-160107] [PMID: 27802220]
[44]
Moustafa, AA; Bilson, L; Jaroudi, W Alzheimer’s Disease: Understanding biomarkers, big data, and therapy. In: Treatment of depression in Alzheimer’s disease; Academic Press, 2022; pp. 177-189.
[http://dx.doi.org/10.1016/B978-0-12-821334-6.00012-0]
[45]
Moustafa, AA; Heikal, SA; Jaroudi, W; Helal, A Stress and anxiety in dementia. Alzheimer's Disease, 2022, 55-74.
[http://dx.doi.org/10.1016/B978-0-12-821334-6.00006-5]
[46]
Sinclair, L.I.; Ballard, C.G. Persistent depressive symptoms are associated with frontal regional atrophy in patients with Alzheimer’s disease. Int. J. Geriatr. Psychiatry, 2023, 38(1), e5858.
[http://dx.doi.org/10.1002/gps.5858] [PMID: 36482861]
[47]
Botto, R.; Callai, N.; Cermelli, A.; Causarano, L.; Rainero, I. Anxiety and depression in Alzheimer’s disease: A systematic review of pathogenetic mechanisms and relation to cognitive decline. Neurol. Sci., 2022, 43(7), 4107-4124.
[http://dx.doi.org/10.1007/s10072-022-06068-x] [PMID: 35461471]
[48]
Panza, F.; Frisardi, V.; Capurso, C.; D’Introno, A.; Colacicco, A.M.; Imbimbo, B.P.; Santamato, A.; Vendemiale, G.; Seripa, D.; Pilotto, A.; Capurso, A.; Solfrizzi, V. Late-life depression, mild cognitive impairment, and dementia: Possible continuum? Am. J. Geriatr. Psychiatry, 2010, 18(2), 98-116.
[http://dx.doi.org/10.1097/JGP.0b013e3181b0fa13] [PMID: 20104067]
[49]
Linnemann, C.; Lang, U.E. Pathways connecting late-life depression and dementia. Front. Pharmacol., 2020, 11, 279.
[http://dx.doi.org/10.3389/fphar.2020.00279] [PMID: 32231570]
[50]
Si, T.; Xing, G.; Han, Y. Subjective cognitive decline and related cognitive deficits. Front. Neurol., 2020, 11, 247.
[http://dx.doi.org/10.3389/fneur.2020.00247] [PMID: 32508729]
[51]
Hill, N.L.; Mogle, J.; Bhargava, S.; Bell, T.R.; Bhang, I.; Katz, M.; Sliwinski, M.J. Longitudinal relationships among depressive symptoms and three types of memory self-report in cognitively intact older adults. Int. Psychogeriatr., 2020, 32(6), 719-732.
[http://dx.doi.org/10.1017/S104161021900084X] [PMID: 31309918]
[52]
Crane, M.K.; Bogner, H.R.; Brown, G.K.; Gallo, J.J. The link between depressive symptoms, negative cognitive bias and memory complaints in older adults. Aging Ment. Health, 2007, 11(6), 708-715.
[http://dx.doi.org/10.1080/13607860701368497] [PMID: 18074258]
[53]
Dotson, V.M.; Beydoun, M.A.; Zonderman, A.B. Recurrent depressive symptoms and the incidence of dementia and mild cognitive impairment. Neurology, 2010, 75(1), 27-34.
[http://dx.doi.org/10.1212/WNL.0b013e3181e62124] [PMID: 20603482]
[54]
Mourao, R.J.; Mansur, G.; Malloy-Diniz, L.F.; Castro Costa, E.; Diniz, B.S. Depressive symptoms increase the risk of progression to dementia in subjects with mild cognitive impairment: Systematic review and meta-analysis. Int. J. Geriatr. Psychiatry, 2016, 31(8), 905-911.
[http://dx.doi.org/10.1002/gps.4406] [PMID: 26680599]
[55]
Mah, L.; Binns, M.A.; Steffens, D.C. Anxiety symptoms in amnestic mild cognitive impairment are associated with medial temporal atrophy and predict conversion to Alzheimer disease. Am. J. Geriatr. Psychiatry, 2015, 23(5), 466-476.
[http://dx.doi.org/10.1016/j.jagp.2014.10.005] [PMID: 25500120]
[56]
Bartels, C.; Wagner, M.; Wolfsgruber, S.; Ehrenreich, H.; Schneider, A. Impact of SSRI therapy on risk of conversion from mild cognitive impairment to Alzheimer’s dementia in individuals with previous depression. Am. J. Psychiatry, 2018, 175(3), 232-241.
[http://dx.doi.org/10.1176/appi.ajp.2017.17040404] [PMID: 29179578]
[57]
Kwak, Y.T.; Yang, Y.; Koo, M.S. Anxiety in dementia. Dement. Neurocognitive Disord., 2017, 16(2), 33-39.
[http://dx.doi.org/10.12779/dnd.2017.16.2.33] [PMID: 30906368]
[58]
Kaiser, N.C.; Liang, L.J.; Melrose, R.J.; Wilkins, S.S.; Sultzer, D.L.; Mendez, M.F. Differences in anxiety among patients with early- versus late-onset Alzheimer’s disease. J. Neuropsychiatry Clin. Neurosci., 2014, 26(1), 73-80.
[http://dx.doi.org/10.1176/appi.neuropsych.12100240] [PMID: 24515678]
[59]
Ferretti, L.; McCurry, S.M.; Logsdon, R.; Gibbons, L.; Teri, L. Anxiety and Alzheimer’s disease. J. Geriatr. Psychiatry Neurol., 2001, 14(1), 52-58.
[http://dx.doi.org/10.1177/089198870101400111] [PMID: 11281317]
[60]
Devier, D.J.; Pelton, G.H.; Tabert, M.H.; Liu, X.; Cuasay, K.; Eisenstadt, R.; Marder, K.; Stern, Y.; Devanand, D.P. The impact of anxiety on conversion from mild cognitive impairment to Alzheimer’s disease. Int. J. Geriatr. Psychiatry, 2009, 24(12), 1335-1342.
[http://dx.doi.org/10.1002/gps.2263] [PMID: 19319929]
[61]
Liew, T.M. Subjective cognitive decline, anxiety symptoms, and the risk of mild cognitive impairment and dementia. Alzheimers Res. Ther., 2020, 12(1), 107.
[http://dx.doi.org/10.1186/s13195-020-00673-8] [PMID: 32917264]
[62]
Cai, W.J.; Tian, Y.; Ma, Y.H.; Dong, Q.; Tan, L.; Yu, J.T. Associations of anxiety with amyloid, Tau, and neurodegeneration in older adults without dementia: A longitudinal study. J. Alzheimers Dis., 2021, 82(1), 273-283.
[http://dx.doi.org/10.3233/JAD-210020] [PMID: 34024826]
[63]
Dux, M.C.; Woodard, J.L.; Calamari, J.; Messina, M.; Arora, S.; Chik, H.; Pontarelli, N. The moderating role of negative affect on objective verbal memory performance and subjective memory complaints in healthy older adults. J. Int. Neuropsychol. Soc., 2008, 14(2), 327-336.
[http://dx.doi.org/10.1017/S1355617708080363] [PMID: 18282330]
[64]
Balash, Y.; Mordechovich, M.; Shabtai, H.; Giladi, N.; Gurevich, T.; Korczyn, A.D. Subjective memory complaints in elders: Depression, anxiety, or cognitive decline? Acta Neurol. Scand., 2013, 127(5), 344-350.
[http://dx.doi.org/10.1111/ane.12038] [PMID: 23215819]
[65]
Chao, L.L. Evidence of objective memory impairments in deployed gulf war veterans with subjective memory complaints. Mil. Med., 2017, 182(5), e1625-e1631.
[http://dx.doi.org/10.7205/MILMED-D-16-00309] [PMID: 29087904]
[66]
Justice, N.J. The relationship between stress and Alzheimer’s disease. Neurobiol. Stress, 2018, 8, 127-133.
[http://dx.doi.org/10.1016/j.ynstr.2018.04.002] [PMID: 29888308]
[67]
O’Brien, J.T.; Schweitzer, I.; Ames, D.; Mastwyk, M.; Colman, P. The function of the hypothalamic-pituitary-adrenal axis in Alzheimer’s disease. Response to insulin hypoglycaemia. Br. J. Psychiatry, 1994, 165(5), 650-657.
[http://dx.doi.org/10.1192/bjp.165.5.650] [PMID: 7866680]
[68]
Du, X.; Pang, T.Y. Is dysregulation of the HPA-Axis a core pathophysiology mediating co-morbid depression in neurodegenerative diseases? Front. Psychiatry, 2015, 6, 32.
[http://dx.doi.org/10.3389/fpsyt.2015.00032] [PMID: 25806005]
[69]
Sapolsky, R.M. Stress, glucocorticoids, and damage to the nervous system: The current state of confusion. Stress, 1996, 1(1), 1-19.
[http://dx.doi.org/10.3109/10253899609001092] [PMID: 9807058]
[70]
Sexton, C.E.; Masurier, M.L.; Allan, C.L.; Jenkinson, M.; McDermott, L.; Kalu, U.G.; Herrmann, L.L.; Bradley, K.M.; Mackay, C.E.; Ebmeier, K.P. Magnetic resonance imaging in late-life depression: vascular and glucocorticoid cascade hypotheses. Br. J. Psychiatry, 2012, 201(1), 46-51.
[http://dx.doi.org/10.1192/bjp.bp.111.105361] [PMID: 22753853]
[71]
Rothman, S.M.; Mattson, M.P. Adverse stress, hippocampal networks, and Alzheimer’s disease. Neuromolecular Med., 2010, 12(1), 56-70.
[http://dx.doi.org/10.1007/s12017-009-8107-9] [PMID: 19943124]
[72]
Sapolsky, R.M.; Krey, L.C.; McEwen, B.S. The neuroendocrinology of stress and aging: The glucocorticoid cascade hypothesis. Sci. SAGE KE, 2002, 2002(38), cp21-cp21.
[http://dx.doi.org/10.1126/sageke.2002.38.cp21]
[73]
Kang, J.E.; Cirrito, J.R.; Dong, H.; Csernansky, J.G.; Holtzman, D.M. Acute stress increases interstitial fluid amyloid-β via corticotropin-releasing factor and neuronal activity. Proc. Natl. Acad. Sci. USA, 2007, 104(25), 10673-10678.
[http://dx.doi.org/10.1073/pnas.0700148104] [PMID: 17551018]
[74]
Carroll, J.C.; Iba, M.; Bangasser, D.A.; Valentino, R.J.; James, M.J.; Brunden, K.R.; Lee, V.M.Y.; Trojanowski, J.Q. Chronic stress exacerbates tau pathology, neurodegeneration, and cognitive performance through a corticotropin-releasing factor receptor-dependent mechanism in a transgenic mouse model of tauopathy. J. Neurosci., 2011, 31(40), 14436-14449.
[http://dx.doi.org/10.1523/JNEUROSCI.3836-11.2011] [PMID: 21976528]
[75]
Khoo, S.A.; Chen, T.Y.; Ang, Y.H.; Yap, P. The impact of neuropsychiatric symptoms on caregiver distress and quality of life in persons with dementia in an Asian tertiary hospital memory clinic. Int. Psychogeriatr., 2013, 25(12), 1991-1999.
[http://dx.doi.org/10.1017/S1041610213001518] [PMID: 24230964]
[76]
Isik, A.T.; Soysal, P.; Solmi, M.; Veronese, N. Bidirectional relationship between caregiver burden and neuropsychiatric symptoms in patients with Alzheimer’s disease: A narrative review. Int. J. Geriatr. Psychiatry, 2019, 34(9), 1326-1334.
[http://dx.doi.org/10.1002/gps.4965] [PMID: 30198597]
[77]
Simard, M.; Hudon, C.; van Reekum, R. Psychological distress and risk for dementia. Curr. Psychiatry Rep., 2009, 11(1), 41-47.
[http://dx.doi.org/10.1007/s11920-009-0007-z] [PMID: 19187707]
[78]
Souza-Talarico, J.N.; Chaves, E.C.; Nitrini, R.; Caramelli, P. Chronic stress is associated with high cortisol levels and emotional coping mechanisms in amnestic mild cognitive impairment. Dement. Geriatr. Cogn. Disord., 2009, 28(5), 450-455.
[http://dx.doi.org/10.1159/000259696] [PMID: 19940478]
[79]
Stuart, K.E.; Padgett, C. A systematic review of the association between psychological stress and dementia risk in humans. J. Alzheimers Dis., 2020, 78(1), 335-352.
[http://dx.doi.org/10.3233/JAD-191096] [PMID: 33016901]
[80]
Hwang, E.H.; Kim, K.H. Effects of cognition, daily-living stress, and health-promotion behavior on subjective memory complaints by community-dwelling elders. J. Korean Gerontol. Nurs., 2019, 21(3), 135-143.
[http://dx.doi.org/10.17079/jkgn.2019.21.3.135]
[81]
Miley-Akerstedt, A.; Jelic, V.; Marklund, K.; Walles, H.; Åkerstedt, T.; Hagman, G.; Andersson, C. Lifestyle factors are important contributors to subjective memory complaints among patients without objective memory impairment or positive neurochemical biomarkers for Alzheimer’s Disease. Dement. Geriatr. Cogn. Disord. Extra, 2018, 8(3), 439-452.
[http://dx.doi.org/10.1159/000493749] [PMID: 30631336]
[82]
Berk, L.; Hotterbeekx, R.; van Os, J.; van Boxtel, M. Mindfulness-based stress reduction in middle-aged and older adults with memory complaints: A mixed-methods study. Aging Ment. Health, 2018, 22(9), 1113-1120.
[http://dx.doi.org/10.1080/13607863.2017.1347142] [PMID: 28721742]
[83]
Wolf, O.T.; Dziobek, I.; McHugh, P.; Sweat, V.; de Leon, M.J.; Javier, E.; Convit, A. Subjective memory complaints in aging are associated with elevated cortisol levels. Neurobiol. Aging, 2005, 26(10), 1357-1363.
[http://dx.doi.org/10.1016/j.neurobiolaging.2004.11.003] [PMID: 16243606]
[84]
Ellendt, S.; Voβ, B.; Kohn, N.; Wagels, L.; Goerlich, K.S.; Drexler, E.; Schneider, F.; Habel, U. Predicting stability of mild cognitive impairment (MCI): Findings of a community based sample. Curr. Alzheimer Res., 2017, 14(6), 608-619.
[http://dx.doi.org/10.2174/1567205014666161213120807] [PMID: 27978792]
[85]
Jessen, F.; Wolfsgruber, S.; Wiese, B.; Bickel, H.; Mösch, E.; Kaduszkiewicz, H.; Pentzek, M.; Riedel-Heller, S.G.; Luck, T.; Fuchs, A.; Weyerer, S.; Werle, J.; van den Bussche, H.; Scherer, M.; Maier, W.; Wagner, M. AD dementia risk in late MCI, in early MCI, and in subjective memory impairment. Alzheimers Dement., 2014, 10(1), 76-83.
[http://dx.doi.org/10.1016/j.jalz.2012.09.017] [PMID: 23375567]
[86]
Alashwal, H.; Diallo, T.M.O.; Tindle, R.; Moustafa, A.A. Latent class and transition analysis of Alzheimer’s disease data. Front. Comput. Sci., 2020, 2, 551481.
[http://dx.doi.org/10.3389/fcomp.2020.551481]
[87]
Chan, W.C.; Lam, L.C.W.; Tam, C.W.C.; Lui, V.W.C.; Chan, S.S.M.; Chan, W.M.; Chiu, H.F.K. Prevalence of neuropsychiatric symptoms in chinese older persons with mild cognitive impairment-a population-based study. Am. J. Geriatr. Psychiatry, 2010, 18(10), 948-954.
[http://dx.doi.org/10.1097/JGP.0b013e3181d69467] [PMID: 20808089]
[88]
Feng, L.; Yap, P.L.K.; Lee, T.S.; Ng, T.P. Neuropsychiatric symptoms in mild cognitive impairment: A population-based study. Asia-Pac. Psychiatry, 2009, 1(1), 23-27.
[http://dx.doi.org/10.1111/j.1758-5872.2009.00005.x]
[89]
Lyketsos, C.G.; Olin, J. Depression in Alzheimer’s disease: Overview and treatment. Biol. Psychiatry, 2002, 52(3), 243-252.
[http://dx.doi.org/10.1016/S0006-3223(02)01348-3] [PMID: 12182930]

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