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Current Alzheimer Research

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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Review Article

Common Neuropsychiatric Symptoms in Alzheimer’s Disease, Mild Cognitive Impairment, and Subjective Memory Complaints: A Unified Framework

Author(s): Samuel L. Warren*, Eid Abo Hamza, Richard Tindle, Edwina Reid, Paige Whitfield, Adam Doumit and Ahmed A. Moustafa

Volume 20, Issue 7, 2023

Published on: 23 October, 2023

Page: [459 - 470] Pages: 12

DOI: 10.2174/0115672050255489231012072014

Price: $65

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Abstract

The Alzheimer’s disease (AD) continuum is a unique spectrum of cognitive impairment that typically involves the stages of subjective memory complaints (SMC), mild cognitive impairment (MCI), and AD dementia. Neuropsychiatric symptoms (NPS), such as apathy, anxiety, stress, and depression, are highly common throughout the AD continuum. However, there is a dearth of research on how these NPS vary across the AD continuum, especially SMC. There is also disagreement on the effects of specific NPS on each stage of the AD continuum due to their collinearity with other NPS, cognitive decline, and environmental factors (e.g., stress). In this article, we conduct a novel perspective review of the scientific literature to understand the presence of NPS across the AD continuum. Specifically, we review the effects of apathy, depression, anxiety, and stress in AD, MCI, and SMC. We then build on this knowledge by proposing two theories of NPS’ occurrence across the AD continuum. Consequently, we highlight the current landscape, limitations (e.g., differing operationalization), and contentions surrounding the NPS literature. We also outline theories that could clear up contention and inspire future NPS research.

Keywords: Neuropsychiatric symptoms (NPS), Alzheimer’s disease (AD), mild cognitive impairment (MCI), subjective memory complaints (SMC), stress, dementia, depression.

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[1]
Bruen, P.D.; McGeown, W.J.; Shanks, M.F.; Venneri, A. Neuroanatomical correlates of neuropsychiatric symptoms in Alzheimer’s disease. Brain, 2008, 131(9), 2455-2463.
[http://dx.doi.org/10.1093/brain/awn151] [PMID: 18669506]
[2]
Mendez, M.F. The relationship between anxiety and Alzheimer’s Disease1. J. Alzheimers Dis. Rep., 2021, 5(1), 171-177.
[http://dx.doi.org/10.3233/ADR-210294] [PMID: 33981954]
[3]
Cummings, J.L.; Mega, M.; Gray, K.; Rosenberg-Thompson, S.; Carusi, D.A.; Gornbein, J. The neuropsychiatric inventory: Comprehensive assessment of psychopathology in dementia. Neurology, 1994, 44(12), 2308-2314.
[http://dx.doi.org/10.1212/WNL.44.12.2308] [PMID: 7991117]
[4]
Jaroudi, W.; Garami, J.; Garrido, S.; Hornberger, M.; Keri, S.; Moustafa, A.A. Factors underlying cognitive decline in old age and Alzheimer’s disease: The role of the hippocampus. Rev. Neurosci., 2017, 28(7), 705-714.
[http://dx.doi.org/10.1515/revneuro-2016-0086] [PMID: 28422707]
[5]
Lanctôt, K.L.; Amatniek, J.; Ancoli-Israel, S.; Arnold, S.E.; Ballard, C.; Cohen-Mansfield, J.; Ismail, Z.; Lyketsos, C.; Miller, D.S.; Musiek, E.; Osorio, R.S.; Rosenberg, P.B.; Satlin, A.; Steffens, D.; Tariot, P.; Bain, L.J.; Carrillo, M.C.; Hendrix, J.A.; Jurgens, H.; Boot, B. Neuropsychiatric signs and symptoms of Alzheimer’s disease: New treatment paradigms. Alzheimers Dement., 2017, 3(3), 440-449.
[http://dx.doi.org/10.1016/j.trci.2017.07.001] [PMID: 29067350]
[6]
Lyketsos, C.G.; Carrillo, M.C.; Ryan, J.M.; Khachaturian, A.S.; Trzepacz, P.; Amatniek, J.; Cedarbaum, J.; Brashear, R.; Miller, D.S. Neuropsychiatric symptoms in Alzheimer’s disease. Alzheimers Dement., 2011, 7(5), 532-539.
[http://dx.doi.org/10.1016/j.jalz.2011.05.2410] [PMID: 21889116]
[7]
Bensamoun, D.; Guignard, R.; Furst, A.J.; Derreumaux, A.; Manera, V.; Darcourt, J.; Benoit, M.; Robert, P.H.; David, R. Associations between neuropsychiatric symptoms and cerebral amyloid deposition in cognitively impaired elderly people. J. Alzheimers Dis., 2015, 49(2), 387-398.
[http://dx.doi.org/10.3233/JAD-150181] [PMID: 26484900]
[8]
Cassidy, C.M.; Therriault, J.; Pascoal, T.A.; Cheung, V.; Savard, M.; Tuominen, L.; Chamoun, M.; McCall, A.; Celebi, S.; Lussier, F.; Massarweh, G.; Soucy, J.P.; Weinshenker, D.; Tardif, C.; Ismail, Z.; Gauthier, S.; Rosa-Neto, P. Association of locus coeruleus integrity with Braak stage and neuropsychiatric symptom severity in Alzheimer’s disease. Neuropsychopharmacology, 2022, 47(5), 1128-1136.
[http://dx.doi.org/10.1038/s41386-022-01293-6] [PMID: 35177805]
[9]
Chen, Y.; Dang, M.; Zhang, Z. Brain mechanisms underlying neuropsychiatric symptoms in Alzheimer’s disease: A systematic review of symptom-general and –specific lesion patterns. Mol. Neurodegener., 2021, 16(1), 38.
[http://dx.doi.org/10.1186/s13024-021-00456-1] [PMID: 34099005]
[10]
Mroczek, M.; Clark, C.; Dayon, L.; Bowman, G.L.; Popp, J. Cerebrospinal fluid proteome alterations associated with neuropsychiatric symptoms in cognitive decline and alzheimer’s disease. Cells, 2022, 11(6), 1030.
[http://dx.doi.org/10.3390/cells11061030] [PMID: 35326481]
[11]
Veitch, D.P.; Weiner, M.W.; Aisen, P.S.; Beckett, L.A.; Cairns, N.J.; Green, R.C.; Harvey, D.; Jack, C.R., Jr; Jagust, W.; Morris, J.C.; Petersen, R.C.; Saykin, A.J.; Shaw, L.M.; Toga, A.W.; Trojanowski, J.Q. Understanding disease progression and improving Alzheimer’s disease clinical trials: Recent highlights from the Alzheimer’s Disease Neuroimaging Initiative. Alzheimers Dement., 2019, 15(1), 106-152.
[http://dx.doi.org/10.1016/j.jalz.2018.08.005] [PMID: 30321505]
[12]
American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 5th ed; American Psychiatric Publishing: Washington, D.C, 2013.
[13]
Taragano, F.E.; Allegri, R.F.; Heisecke, S.L.; Martelli, M.I.; Feldman, M.L.; Sánchez, V.; García, V.A.; Tufro, G.; Castro, D.M.; Leguizamón, P.P.; Guelar, V.; Ruotolo, E.; Zegarra, C.; Dillon, C. Risk of conversion to dementia in a mild behavioral impairment group compared to a psychiatric group and to a mild cognitive impairment group. J. Alzheimers Dis., 2018, 62(1), 227-238.
[http://dx.doi.org/10.3233/JAD-170632] [PMID: 29439333]
[14]
Ma, L. Depression, anxiety, and apathy in mild cognitive impairment: Current perspectives. Front. Aging Neurosci., 2020, 12, 9.
[http://dx.doi.org/10.3389/fnagi.2020.00009] [PMID: 32082139]
[15]
Palmer, K.; Di Iulio, F.; Varsi, A.E.; Gianni, W.; Sancesario, G.; Caltagirone, C.; Spalletta, G. Neuropsychiatric predictors of progression from amnestic-mild cognitive impairment to Alzheimer’s disease: The role of depression and apathy. J. Alzheimers Dis., 2010, 20(1), 175-183.
[http://dx.doi.org/10.3233/JAD-2010-1352] [PMID: 20164594]
[16]
Brigola, A.G.; Manzini, C.S.S.; Oliveira, G.B.S.; Ottaviani, A.C.; Sako, M.P.; Vale, F.A.C. Subjective memory complaints associated with depression and cognitive impairment in the elderly: A systematic review. Dement. Neuropsychol., 2015, 9(1), 51-57.
[http://dx.doi.org/10.1590/S1980-57642015DN91000009] [PMID: 29213941]
[17]
Warren, S.L.; Reid, E.; Whitfield, P.; Moustafa, A.A. Subjective memory complaints as a predictor of mild cognitive impairment and Alzheimer’s disease. Discover Psychology, 2022, 2(1), 13.
[http://dx.doi.org/10.1007/s44202-022-00031-9]
[18]
Boutoleau-Bretonnière, C.; Pouclet-Courtemanche, H.; Gillet, A.; Bernard, A.; Deruet, A.L.; Gouraud, I.; Mazoue, A.; Lamy, E.; Rocher, L.; Kapogiannis, D.; El Haj, M. The effects of confinement on neuropsychiatric symptoms in Alzheimer’s disease during the COVID-19 crisis. J. Alzheimers Dis., 2020, 76(1), 41-47.
[http://dx.doi.org/10.3233/JAD-200604] [PMID: 32568211]
[19]
Yates, J.A.; Clare, L.; Woods, R.T. Subjective memory complaints, mood and MCI: A follow-up study. Aging Ment. Health, 2017, 21(3), 313-321.
[http://dx.doi.org/10.1080/13607863.2015.1081150] [PMID: 26329364]
[20]
Geda, Y.E.; Schneider, L.S.; Gitlin, L.N.; Miller, D.S.; Smith, G.S.; Bell, J.; Evans, J.; Lee, M.; Porsteinsson, A.; Lanctôt, K.L.; Rosenberg, P.B.; Sultzer, D.L.; Francis, P.T.; Brodaty, H.; Padala, P.P.; Onyike, C.U.; Ortiz, L.A.; Ancoli-Israel, S.; Bliwise, D.L.; Martin, J.L.; Vitiello, M.V.; Yaffe, K.; Zee, P.C.; Herrmann, N.; Sweet, R.A.; Ballard, C.; Khin, N.A.; Alfaro, C.; Murray, P.S.; Schultz, S.; Lyketsos, C.G. Neuropsychiatric symptoms in Alzheimer’s disease: Past progress and anticipation of the future. Alzheimers Dement., 2013, 9(5), 602-608.
[http://dx.doi.org/10.1016/j.jalz.2012.12.001] [PMID: 23562430]
[21]
Van Dam, D.; Vermeiren, Y.; Dekker, A.D.; Naudé, P.J.; Deyn, P.P. Neuropsychiatric disturbances in Alzheimer’s disease: What have we learned from neuropathological studies? Curr. Alzheimer Res., 2016, 13(10), 1145-1164.
[http://dx.doi.org/10.2174/1567205013666160502123607] [PMID: 27137218]
[22]
Wolinsky, D.; Drake, K.; Bostwick, J. Diagnosis and management of neuropsychiatric symptoms in Alzheimer’s disease. Curr. Psychiatry Rep., 2018, 20(12), 117.
[http://dx.doi.org/10.1007/s11920-018-0978-8] [PMID: 30367272]
[23]
Lanza, S.T.; Flaherty, B.P.; Collins, L.M. Latent class and latent transition analysis.Handbook of psychology: Research methods in psychology; John Wiley & Sons, Inc.: Hoboken, NJ, US, 2003, Vol. 2, pp. 663-685.
[http://dx.doi.org/10.1002/0471264385.wei0226]
[24]
Mehak, S.F.; Shivakumar, A.B.; Saraf, V.; Johansson, M.; Gangadharan, G. Apathy in Alzheimer’s disease: A neurocircuitry based perspective. Ageing Res. Rev., 2023, 87, 101891.
[http://dx.doi.org/10.1016/j.arr.2023.101891] [PMID: 36871779]
[25]
Mortby, M.E.; Adler, L.; Agüera-Ortiz, L.; Bateman, D.R.; Brodaty, H.; Cantillon, M.; Geda, Y.E.; Ismail, Z.; Lanctôt, K.L.; Marshall, G.A.; Padala, P.R.; Politis, A.; Rosenberg, P.B.; Siarkos, K.; Sultzer, D.L.; Theleritis, C. Apathy as a treatment target in alzheimer’s disease: Implications for clinical trials. Am. J. Geriatr. Psychiatry, 2022, 30(2), 119-147.
[http://dx.doi.org/10.1016/j.jagp.2021.06.016] [PMID: 34315645]
[26]
Richard, E.; Schmand, B.; Eikelenboom, P.; Yang, S.C.; Ligthart, S.A.; Moll van Charante, E.P.; van Gool, W.A. Symptoms of apathy are associated with progression from mild cognitive impairment to Alzheimer’s disease in non-depressed subjects. Dement. Geriatr. Cogn. Disord., 2012, 33(2-3), 204-209.
[http://dx.doi.org/10.1159/000338239] [PMID: 22722671]
[27]
Robert, P.; Onyike, C.U.; Leentjens, A.F.G.; Dujardin, K.; Aalten, P.; Starkstein, S.; Verhey, F.R.J.; Yessavage, J.; Clement, J.P.; Drapier, D.; Bayle, F.; Benoit, M.; Boyer, P.; Lorca, P.M.; Thibaut, F.; Gauthier, S.; Grossberg, G.; Vellas, B.; Byrne, J. Proposed diagnostic criteria for apathy in Alzheimer’s disease and other neuropsychiatric disorders. Eur. Psychiatry, 2009, 24(2), 98-104.
[http://dx.doi.org/10.1016/j.eurpsy.2008.09.001] [PMID: 19201579]
[28]
Nobis, L.; Husain, M. Apathy in Alzheimer’s disease. Curr. Opin. Behav. Sci., 2018, 22, 7-13.
[http://dx.doi.org/10.1016/j.cobeha.2017.12.007] [PMID: 30123816]
[29]
Zhang, M.; Wang, H.; Li, T.; Yu, X. Prevalence of neuropsychiatric symptoms across the declining memory continuum: An observational study in a memory clinic setting. Dement. Geriatr. Cogn. Disord. Extra, 2012, 2(1), 200-208.
[http://dx.doi.org/10.1159/000338410] [PMID: 22719746]
[30]
Teixeira, A.L.; Gonzales, M.M.; de Souza, L.C.; Weisenbach, S.L. Revisiting apathy in Alzheimer’s Disease: From conceptualization to therapeutic approaches. Behav. Neurol., 2021, 2021, 1-8.
[http://dx.doi.org/10.1155/2021/6319826] [PMID: 34394772]
[31]
Landes, A.M.; Sperry, S.D.; Strauss, M.E.; Geldmacher, D.S. Apathy in Alzheimer’s disease. J. Am. Geriatr. Soc., 2001, 49(12), 1700-1707.
[http://dx.doi.org/10.1046/j.1532-5415.2001.49282.x] [PMID: 11844006]
[32]
Robert, P.H.; Berr, C.; Volteau, M.; Bertogliati, C.; Benoit, M.; Mahieux, F.; Legrain, S.; Dubois, B. Neuropsychological performance in mild cognitive impairment with and without apathy. Dement. Geriatr. Cogn. Disord., 2006, 21(3), 192-197.
[http://dx.doi.org/10.1159/000090766] [PMID: 16424666]
[33]
Zhao, J.; Jin, X.; Chen, B.; Fu, C.; Ji, S.; Shen, W.; Wei, J.; Zheng, H.; Zhang, Y. Apathy symptoms increase the risk of dementia conversion: a case‐matching cohort study on patients with post‐stroke mild cognitive impairment in CHINA. Psychogeriatrics, 2021, 21(2), 149-157.
[http://dx.doi.org/10.1111/psyg.12634] [PMID: 33395732]
[34]
Duara, R.; Loewenstein, D.A.; Potter, E.; Barker, W.; Raj, A.; Schoenberg, M.; Wu, Y.; Banko, J.; Potter, H.; Greig, M.T.; Schinka, J.; Borenstein, A. Pre-MCI and MCI: Neuropsychological, clinical, and imaging features and progression rates. Am. J. Geriatr. Psychiatry, 2011, 19(11), 951-960.
[http://dx.doi.org/10.1097/JGP.0b013e3182107c69] [PMID: 21422909]
[35]
Martin, E.; Velayudhan, L. Neuropsychiatric symptoms in mild cognitive impairment: A literature review. Dement. Geriatr. Cogn. Disord., 2020, 49(2), 146-155.
[http://dx.doi.org/10.1159/000507078] [PMID: 32289790]
[36]
Hwang, T.J.; Masterman, D.L.; Ortiz, F.; Fairbanks, L.A.; Cummings, J.L. Mild cognitive impairment is associated with characteristic neuropsychiatric symptoms. Alzheimer Dis. Assoc. Disord., 2004, 18(1), 17-21.
[http://dx.doi.org/10.1097/00002093-200401000-00004] [PMID: 15195459]
[37]
Ruthirakuhan, M.; Herrmann, N.; Vieira, D.; Gallagher, D.; Lanctôt, K.L. The roles of apathy and depression in predicting alzheimer disease: A longitudinal analysis in older adults with mild cognitive impairment. Am. J. Geriatr. Psychiatry, 2019, 27(8), 873-882.
[http://dx.doi.org/10.1016/j.jagp.2019.02.003] [PMID: 30910421]
[38]
Elfgren, C.; Gustafson, L.; Vestberg, S.; Passant, U. Subjective memory complaints, neuropsychological performance and psychiatric variables in memory clinic attendees: A 3-year follow-up study. Arch. Gerontol. Geriatr., 2010, 51(3), e110-e114.
[http://dx.doi.org/10.1016/j.archger.2010.02.009] [PMID: 20211500]
[39]
Kawagoe, T.; Onoda, K.; Yamaguchi, S. Subjective memory complaints are associated with altered resting-state functional connectivity but not structural atrophy. Neuroimage Clin., 2019, 21, 101675.
[http://dx.doi.org/10.1016/j.nicl.2019.101675] [PMID: 30642761]
[40]
Guercio, B.J.; Donovan, N.J.; Munro, C.E.; Aghjayan, S.L.; Wigman, S.E.; Locascio, J.J.; Amariglio, R.E.; Rentz, D.M.; Johnson, K.A.; Sperling, R.A.; Marshall, G.A. The apathy evaluation scale: A comparison of subject, informant, and clinician report in cognitively normal elderly and mild cognitive impairment. J. Alzheimers Dis., 2015, 47(2), 421-432.
[http://dx.doi.org/10.3233/JAD-150146] [PMID: 26401564]
[41]
Johansson, M.; Stomrud, E.; Lindberg, O.; Westman, E.; Johansson, P.M.; van Westen, D.; Mattsson, N.; Hansson, O. Apathy and anxiety are early markers of Alzheimer’s disease. Neurobiol. Aging, 2020, 85, 74-82.
[http://dx.doi.org/10.1016/j.neurobiolaging.2019.10.008] [PMID: 31735378]
[42]
Finger, E.; Zhang, J.; Dickerson, B.; Bureau, Y.; Masellis, M. Disinhibition in Alzheimer’s disease is associated with reduced right frontal pole cortical thickness. J. Alzheimers Dis., 2017, 60(3), 1161-1170.
[http://dx.doi.org/10.3233/JAD-170348] [PMID: 28984590]
[43]
Huey, E.D.; Lee, S.; Cheran, G.; Grafman, J.; Devanand, D.P. Brain regions involved in arousal and reward processing are associated with apathy in alzheimer’s disease and frontotemporal dementia. J. Alzheimers Dis., 2016, 55(2), 551-558.
[http://dx.doi.org/10.3233/JAD-160107] [PMID: 27802220]
[44]
Moustafa, AA; Bilson, L; Jaroudi, W Alzheimer’s Disease: Understanding biomarkers, big data, and therapy. In: Treatment of depression in Alzheimer’s disease; Academic Press, 2022; pp. 177-189.
[http://dx.doi.org/10.1016/B978-0-12-821334-6.00012-0]
[45]
Moustafa, AA; Heikal, SA; Jaroudi, W; Helal, A Stress and anxiety in dementia. Alzheimer's Disease, 2022, 55-74.
[http://dx.doi.org/10.1016/B978-0-12-821334-6.00006-5]
[46]
Sinclair, L.I.; Ballard, C.G. Persistent depressive symptoms are associated with frontal regional atrophy in patients with Alzheimer’s disease. Int. J. Geriatr. Psychiatry, 2023, 38(1), e5858.
[http://dx.doi.org/10.1002/gps.5858] [PMID: 36482861]
[47]
Botto, R.; Callai, N.; Cermelli, A.; Causarano, L.; Rainero, I. Anxiety and depression in Alzheimer’s disease: A systematic review of pathogenetic mechanisms and relation to cognitive decline. Neurol. Sci., 2022, 43(7), 4107-4124.
[http://dx.doi.org/10.1007/s10072-022-06068-x] [PMID: 35461471]
[48]
Panza, F.; Frisardi, V.; Capurso, C.; D’Introno, A.; Colacicco, A.M.; Imbimbo, B.P.; Santamato, A.; Vendemiale, G.; Seripa, D.; Pilotto, A.; Capurso, A.; Solfrizzi, V. Late-life depression, mild cognitive impairment, and dementia: Possible continuum? Am. J. Geriatr. Psychiatry, 2010, 18(2), 98-116.
[http://dx.doi.org/10.1097/JGP.0b013e3181b0fa13] [PMID: 20104067]
[49]
Linnemann, C.; Lang, U.E. Pathways connecting late-life depression and dementia. Front. Pharmacol., 2020, 11, 279.
[http://dx.doi.org/10.3389/fphar.2020.00279] [PMID: 32231570]
[50]
Si, T.; Xing, G.; Han, Y. Subjective cognitive decline and related cognitive deficits. Front. Neurol., 2020, 11, 247.
[http://dx.doi.org/10.3389/fneur.2020.00247] [PMID: 32508729]
[51]
Hill, N.L.; Mogle, J.; Bhargava, S.; Bell, T.R.; Bhang, I.; Katz, M.; Sliwinski, M.J. Longitudinal relationships among depressive symptoms and three types of memory self-report in cognitively intact older adults. Int. Psychogeriatr., 2020, 32(6), 719-732.
[http://dx.doi.org/10.1017/S104161021900084X] [PMID: 31309918]
[52]
Crane, M.K.; Bogner, H.R.; Brown, G.K.; Gallo, J.J. The link between depressive symptoms, negative cognitive bias and memory complaints in older adults. Aging Ment. Health, 2007, 11(6), 708-715.
[http://dx.doi.org/10.1080/13607860701368497] [PMID: 18074258]
[53]
Dotson, V.M.; Beydoun, M.A.; Zonderman, A.B. Recurrent depressive symptoms and the incidence of dementia and mild cognitive impairment. Neurology, 2010, 75(1), 27-34.
[http://dx.doi.org/10.1212/WNL.0b013e3181e62124] [PMID: 20603482]
[54]
Mourao, R.J.; Mansur, G.; Malloy-Diniz, L.F.; Castro Costa, E.; Diniz, B.S. Depressive symptoms increase the risk of progression to dementia in subjects with mild cognitive impairment: Systematic review and meta-analysis. Int. J. Geriatr. Psychiatry, 2016, 31(8), 905-911.
[http://dx.doi.org/10.1002/gps.4406] [PMID: 26680599]
[55]
Mah, L.; Binns, M.A.; Steffens, D.C. Anxiety symptoms in amnestic mild cognitive impairment are associated with medial temporal atrophy and predict conversion to Alzheimer disease. Am. J. Geriatr. Psychiatry, 2015, 23(5), 466-476.
[http://dx.doi.org/10.1016/j.jagp.2014.10.005] [PMID: 25500120]
[56]
Bartels, C.; Wagner, M.; Wolfsgruber, S.; Ehrenreich, H.; Schneider, A. Impact of SSRI therapy on risk of conversion from mild cognitive impairment to Alzheimer’s dementia in individuals with previous depression. Am. J. Psychiatry, 2018, 175(3), 232-241.
[http://dx.doi.org/10.1176/appi.ajp.2017.17040404] [PMID: 29179578]
[57]
Kwak, Y.T.; Yang, Y.; Koo, M.S. Anxiety in dementia. Dement. Neurocognitive Disord., 2017, 16(2), 33-39.
[http://dx.doi.org/10.12779/dnd.2017.16.2.33] [PMID: 30906368]
[58]
Kaiser, N.C.; Liang, L.J.; Melrose, R.J.; Wilkins, S.S.; Sultzer, D.L.; Mendez, M.F. Differences in anxiety among patients with early- versus late-onset Alzheimer’s disease. J. Neuropsychiatry Clin. Neurosci., 2014, 26(1), 73-80.
[http://dx.doi.org/10.1176/appi.neuropsych.12100240] [PMID: 24515678]
[59]
Ferretti, L.; McCurry, S.M.; Logsdon, R.; Gibbons, L.; Teri, L. Anxiety and Alzheimer’s disease. J. Geriatr. Psychiatry Neurol., 2001, 14(1), 52-58.
[http://dx.doi.org/10.1177/089198870101400111] [PMID: 11281317]
[60]
Devier, D.J.; Pelton, G.H.; Tabert, M.H.; Liu, X.; Cuasay, K.; Eisenstadt, R.; Marder, K.; Stern, Y.; Devanand, D.P. The impact of anxiety on conversion from mild cognitive impairment to Alzheimer’s disease. Int. J. Geriatr. Psychiatry, 2009, 24(12), 1335-1342.
[http://dx.doi.org/10.1002/gps.2263] [PMID: 19319929]
[61]
Liew, T.M. Subjective cognitive decline, anxiety symptoms, and the risk of mild cognitive impairment and dementia. Alzheimers Res. Ther., 2020, 12(1), 107.
[http://dx.doi.org/10.1186/s13195-020-00673-8] [PMID: 32917264]
[62]
Cai, W.J.; Tian, Y.; Ma, Y.H.; Dong, Q.; Tan, L.; Yu, J.T. Associations of anxiety with amyloid, Tau, and neurodegeneration in older adults without dementia: A longitudinal study. J. Alzheimers Dis., 2021, 82(1), 273-283.
[http://dx.doi.org/10.3233/JAD-210020] [PMID: 34024826]
[63]
Dux, M.C.; Woodard, J.L.; Calamari, J.; Messina, M.; Arora, S.; Chik, H.; Pontarelli, N. The moderating role of negative affect on objective verbal memory performance and subjective memory complaints in healthy older adults. J. Int. Neuropsychol. Soc., 2008, 14(2), 327-336.
[http://dx.doi.org/10.1017/S1355617708080363] [PMID: 18282330]
[64]
Balash, Y.; Mordechovich, M.; Shabtai, H.; Giladi, N.; Gurevich, T.; Korczyn, A.D. Subjective memory complaints in elders: Depression, anxiety, or cognitive decline? Acta Neurol. Scand., 2013, 127(5), 344-350.
[http://dx.doi.org/10.1111/ane.12038] [PMID: 23215819]
[65]
Chao, L.L. Evidence of objective memory impairments in deployed gulf war veterans with subjective memory complaints. Mil. Med., 2017, 182(5), e1625-e1631.
[http://dx.doi.org/10.7205/MILMED-D-16-00309] [PMID: 29087904]
[66]
Justice, N.J. The relationship between stress and Alzheimer’s disease. Neurobiol. Stress, 2018, 8, 127-133.
[http://dx.doi.org/10.1016/j.ynstr.2018.04.002] [PMID: 29888308]
[67]
O’Brien, J.T.; Schweitzer, I.; Ames, D.; Mastwyk, M.; Colman, P. The function of the hypothalamic-pituitary-adrenal axis in Alzheimer’s disease. Response to insulin hypoglycaemia. Br. J. Psychiatry, 1994, 165(5), 650-657.
[http://dx.doi.org/10.1192/bjp.165.5.650] [PMID: 7866680]
[68]
Du, X.; Pang, T.Y. Is dysregulation of the HPA-Axis a core pathophysiology mediating co-morbid depression in neurodegenerative diseases? Front. Psychiatry, 2015, 6, 32.
[http://dx.doi.org/10.3389/fpsyt.2015.00032] [PMID: 25806005]
[69]
Sapolsky, R.M. Stress, glucocorticoids, and damage to the nervous system: The current state of confusion. Stress, 1996, 1(1), 1-19.
[http://dx.doi.org/10.3109/10253899609001092] [PMID: 9807058]
[70]
Sexton, C.E.; Masurier, M.L.; Allan, C.L.; Jenkinson, M.; McDermott, L.; Kalu, U.G.; Herrmann, L.L.; Bradley, K.M.; Mackay, C.E.; Ebmeier, K.P. Magnetic resonance imaging in late-life depression: vascular and glucocorticoid cascade hypotheses. Br. J. Psychiatry, 2012, 201(1), 46-51.
[http://dx.doi.org/10.1192/bjp.bp.111.105361] [PMID: 22753853]
[71]
Rothman, S.M.; Mattson, M.P. Adverse stress, hippocampal networks, and Alzheimer’s disease. Neuromolecular Med., 2010, 12(1), 56-70.
[http://dx.doi.org/10.1007/s12017-009-8107-9] [PMID: 19943124]
[72]
Sapolsky, R.M.; Krey, L.C.; McEwen, B.S. The neuroendocrinology of stress and aging: The glucocorticoid cascade hypothesis. Sci. SAGE KE, 2002, 2002(38), cp21-cp21.
[http://dx.doi.org/10.1126/sageke.2002.38.cp21]
[73]
Kang, J.E.; Cirrito, J.R.; Dong, H.; Csernansky, J.G.; Holtzman, D.M. Acute stress increases interstitial fluid amyloid-β via corticotropin-releasing factor and neuronal activity. Proc. Natl. Acad. Sci. USA, 2007, 104(25), 10673-10678.
[http://dx.doi.org/10.1073/pnas.0700148104] [PMID: 17551018]
[74]
Carroll, J.C.; Iba, M.; Bangasser, D.A.; Valentino, R.J.; James, M.J.; Brunden, K.R.; Lee, V.M.Y.; Trojanowski, J.Q. Chronic stress exacerbates tau pathology, neurodegeneration, and cognitive performance through a corticotropin-releasing factor receptor-dependent mechanism in a transgenic mouse model of tauopathy. J. Neurosci., 2011, 31(40), 14436-14449.
[http://dx.doi.org/10.1523/JNEUROSCI.3836-11.2011] [PMID: 21976528]
[75]
Khoo, S.A.; Chen, T.Y.; Ang, Y.H.; Yap, P. The impact of neuropsychiatric symptoms on caregiver distress and quality of life in persons with dementia in an Asian tertiary hospital memory clinic. Int. Psychogeriatr., 2013, 25(12), 1991-1999.
[http://dx.doi.org/10.1017/S1041610213001518] [PMID: 24230964]
[76]
Isik, A.T.; Soysal, P.; Solmi, M.; Veronese, N. Bidirectional relationship between caregiver burden and neuropsychiatric symptoms in patients with Alzheimer’s disease: A narrative review. Int. J. Geriatr. Psychiatry, 2019, 34(9), 1326-1334.
[http://dx.doi.org/10.1002/gps.4965] [PMID: 30198597]
[77]
Simard, M.; Hudon, C.; van Reekum, R. Psychological distress and risk for dementia. Curr. Psychiatry Rep., 2009, 11(1), 41-47.
[http://dx.doi.org/10.1007/s11920-009-0007-z] [PMID: 19187707]
[78]
Souza-Talarico, J.N.; Chaves, E.C.; Nitrini, R.; Caramelli, P. Chronic stress is associated with high cortisol levels and emotional coping mechanisms in amnestic mild cognitive impairment. Dement. Geriatr. Cogn. Disord., 2009, 28(5), 450-455.
[http://dx.doi.org/10.1159/000259696] [PMID: 19940478]
[79]
Stuart, K.E.; Padgett, C. A systematic review of the association between psychological stress and dementia risk in humans. J. Alzheimers Dis., 2020, 78(1), 335-352.
[http://dx.doi.org/10.3233/JAD-191096] [PMID: 33016901]
[80]
Hwang, E.H.; Kim, K.H. Effects of cognition, daily-living stress, and health-promotion behavior on subjective memory complaints by community-dwelling elders. J. Korean Gerontol. Nurs., 2019, 21(3), 135-143.
[http://dx.doi.org/10.17079/jkgn.2019.21.3.135]
[81]
Miley-Akerstedt, A.; Jelic, V.; Marklund, K.; Walles, H.; Åkerstedt, T.; Hagman, G.; Andersson, C. Lifestyle factors are important contributors to subjective memory complaints among patients without objective memory impairment or positive neurochemical biomarkers for Alzheimer’s Disease. Dement. Geriatr. Cogn. Disord. Extra, 2018, 8(3), 439-452.
[http://dx.doi.org/10.1159/000493749] [PMID: 30631336]
[82]
Berk, L.; Hotterbeekx, R.; van Os, J.; van Boxtel, M. Mindfulness-based stress reduction in middle-aged and older adults with memory complaints: A mixed-methods study. Aging Ment. Health, 2018, 22(9), 1113-1120.
[http://dx.doi.org/10.1080/13607863.2017.1347142] [PMID: 28721742]
[83]
Wolf, O.T.; Dziobek, I.; McHugh, P.; Sweat, V.; de Leon, M.J.; Javier, E.; Convit, A. Subjective memory complaints in aging are associated with elevated cortisol levels. Neurobiol. Aging, 2005, 26(10), 1357-1363.
[http://dx.doi.org/10.1016/j.neurobiolaging.2004.11.003] [PMID: 16243606]
[84]
Ellendt, S.; Voβ, B.; Kohn, N.; Wagels, L.; Goerlich, K.S.; Drexler, E.; Schneider, F.; Habel, U. Predicting stability of mild cognitive impairment (MCI): Findings of a community based sample. Curr. Alzheimer Res., 2017, 14(6), 608-619.
[http://dx.doi.org/10.2174/1567205014666161213120807] [PMID: 27978792]
[85]
Jessen, F.; Wolfsgruber, S.; Wiese, B.; Bickel, H.; Mösch, E.; Kaduszkiewicz, H.; Pentzek, M.; Riedel-Heller, S.G.; Luck, T.; Fuchs, A.; Weyerer, S.; Werle, J.; van den Bussche, H.; Scherer, M.; Maier, W.; Wagner, M. AD dementia risk in late MCI, in early MCI, and in subjective memory impairment. Alzheimers Dement., 2014, 10(1), 76-83.
[http://dx.doi.org/10.1016/j.jalz.2012.09.017] [PMID: 23375567]
[86]
Alashwal, H.; Diallo, T.M.O.; Tindle, R.; Moustafa, A.A. Latent class and transition analysis of Alzheimer’s disease data. Front. Comput. Sci., 2020, 2, 551481.
[http://dx.doi.org/10.3389/fcomp.2020.551481]
[87]
Chan, W.C.; Lam, L.C.W.; Tam, C.W.C.; Lui, V.W.C.; Chan, S.S.M.; Chan, W.M.; Chiu, H.F.K. Prevalence of neuropsychiatric symptoms in chinese older persons with mild cognitive impairment-a population-based study. Am. J. Geriatr. Psychiatry, 2010, 18(10), 948-954.
[http://dx.doi.org/10.1097/JGP.0b013e3181d69467] [PMID: 20808089]
[88]
Feng, L.; Yap, P.L.K.; Lee, T.S.; Ng, T.P. Neuropsychiatric symptoms in mild cognitive impairment: A population-based study. Asia-Pac. Psychiatry, 2009, 1(1), 23-27.
[http://dx.doi.org/10.1111/j.1758-5872.2009.00005.x]
[89]
Lyketsos, C.G.; Olin, J. Depression in Alzheimer’s disease: Overview and treatment. Biol. Psychiatry, 2002, 52(3), 243-252.
[http://dx.doi.org/10.1016/S0006-3223(02)01348-3] [PMID: 12182930]

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