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Review Article

上睑下垂在乳腺癌中的新作用：特征，治疗，以及对现在和未来的转化意义

卷 24, 期 12, 2024

发表于: 17 October, 2023

页: [1470 - 1482] 页: 13

弟呕挨: 10.2174/1566524023666230913105735

价格: $65

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摘要

铁下垂是一种非凋亡的、铁依赖性的细胞死亡形式，可以通过预期的改善和制造的专家在疾病细胞中激活。不同的研究最近重新发现了这种新发现的细胞死亡途径的作用，并证明了它在治疗乳腺癌方面的功效。乳腺癌是全世界女性中最知名的癌症类型。尽管多年来对乳腺癌的细胞死亡进行了研究，但由于其复发的可能性很大，因此计数细胞凋亡和临床治疗遗留问题很困难。铁死亡的定义是磷脂氢过氧化物GPX4缺乏脂质过氧化修复能力，氧化还原活性铁的可及性，以及随后的多不饱和脂肪酸氧化-含脂肪酸的磷脂信号，氨基酸和铁代谢，铁蛋白自噬，上皮-间质转化，细胞粘附，甲羟丙酸和磷脂的生物合成都可能是影响铁死亡易感性的因素。铁下垂是一种由过度脂质过氧化引起的铁依赖性受控细胞死亡，在过去十年中一直与乳腺癌的发展和治疗反应密切相关。加强针对铁下垂的临床药物的进展为治疗乳腺癌带来了一线希望。上睑下垂受代谢和某些基因表达的影响，使其成为监测恶性生长的潜在治疗靶点，也是精确癌症药物披露的一个有吸引力的靶点。在未来的几年里，对乳腺癌患者铁下垂的生物标志物的研究和事件的过程以及随后基于铁下垂的新型治疗方法的使用将是谨慎的。在这篇综述中，我们对与铁下垂相关的分子机制和调控网络的实际理解、生长隐藏的预期生理功能、铁下垂相关的差异表达基因、治疗靶向潜力以及治疗策略的最新进展进行了基本分析。

关键词: 铁下垂，乳腺癌，细胞凋亡，铁蛋白吞噬，精准医学，生物标志物。

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