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当代阿耳茨海默病研究

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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T淋巴细胞在阿尔茨海默病发病机制和进展中的作用：寻找直接的神经病理学证据

卷 20, 期 7, 2023

发表于: 26 September, 2023

页: [453 - 458] 页: 6

弟呕挨: 10.2174/1567205020666230904151011

价格: $65

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摘要

多项研究表明，T细胞在阿尔茨海默病发病机制中发挥着重要作用。鉴于免疫疗法在癌症和多种疾病中的成功应用，T细胞修饰疗法成为开发阿尔茨海默病和神经退行性疾病新疗法的一种有吸引力的方式。然而，这些研究大多涉及外周T细胞反应，而在人类受试者和相关动物模型中，记录T细胞浸润与阿尔茨海默病病理标志物（即淀粉样斑块和神经原纤维角）相关的直接病理证据很少，充其量只是初步的。在这里，我们简要总结了与T细胞浸润直接对应的可用病理数据，批判性地分析了当前的知识差距，并为未来的研究提出了一些关键建议。

关键词: T淋巴细胞，阿尔茨海默病，神经病理学，T细胞修饰治疗，基于免疫的治疗，神经退行性疾病。

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