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Review Article

组蛋白去乙酰化酶在NLRP3炎性体介导的癫痫中的作用

卷 24, 期 8, 2024

发表于: 12 September, 2023

页: [980 - 1003] 页: 24

弟呕挨: 10.2174/1566524023666230731095431

价格: $65

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摘要

癫痫是最常见的脑部疾病之一，不仅在世界范围内导致死亡，而且还影响患者的日常生活。以往的研究表明，炎症在癫痫的病理生理中起着重要作用。炎症小体的激活可以通过促进caspase-1的成熟和各种炎症效应物的分泌来促进神经炎症，包括趋化因子、白细胞介素和肿瘤坏死因子。随着对炎症小体在癫痫发生发展中的作用机制的深入研究，发现NLRP3炎症小体可能通过介导神经元炎症损伤、神经元丢失和血脑屏障功能障碍诱发癫痫。因此，阻断NLRP3炎性小体的激活可能是一种新的癫痫治疗策略。然而，特异性阻断NLRP3炎性小体组装的药物尚未被批准用于临床。本文就炎症调节剂HDACs调控NLRP3炎性小体激活的机制作一综述。这有助于探索HDAC抑制剂抑制脑炎性损伤的机制，为控制癫痫的发展提供潜在的治疗策略。

关键词: 组蛋白去乙酰化酶，癫痫，NLRP3炎性体，神经炎症，NF-κB, TNF-α。

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