Generic placeholder image

Current Traditional Medicine

Editor-in-Chief

ISSN (Print): 2215-0838
ISSN (Online): 2215-0846

Review Article

The Immunology - Ayurveda Perspective

Author(s): Geethu Balakrishnan* and Akhilesh Shukla

Volume 10, Issue 5, 2024

Published on: 24 July, 2023

Article ID: e010623217560 Pages: 14

DOI: 10.2174/2215083810666230601144116

Price: $65

conference banner
Abstract

Introduction: Immunity can be defined as the ability of the human body to resist almost all types of organisms or toxins that tend to damage tissues and organs. Ayurveda, one of the oldest health sciences has its perspectives and practices on immunology delineated under the heads of Vyadhikshmatwa (tolerance against disease), Ojas (the quintessence of all bodily tissues that is responsible for natural bio-strength, vitality and immunity), Bala (strength), and Vikaravighata Bhavas (disease-resisting factors).

Materials and Methods: For the present review, the materials were collected from the Ayurvedic literature, including the three major classical texts Brihatrayees Charaka Samhita, Sushruta Samhita, Ashtanga Samgraha and Ashtanga Hridaya, and their important commentaries by Chakrapani, Arunadutta, Hemadri, Indu, and Dalhana. Information from the current scientific literature, articles published in PubMed, and authentic webpages has also been incorporated into this study. Subsequently, an independent analysis of immunology from Ayurvedic classical texts is presented in this review.

Discussion: Ayurvedic compendia have vividly described the perspectives and practices of immunity and the promotion of disease-resisting factors. In addition to being the repository of age-old medical practices and the treasure trove of herbal drugs, the immunomodulatory effects of these disease-resisting factors hold up even when bridging with new models based on modern science and technology.

Conclusion: Rather than being a complementary science, Ayurveda is enriched with the concepts and practices of immunology. In order to free humanity from the grip of infections, it is important to explore the standalone and integrative aspects of science now.

Keywords: Ayurveda, immunity, immunology, immunomodulatory, Ayurvedic compendia, disease-resisting factors, ayurveda perspective.

Graphical Abstract
[1]
Hajishengallis G, Li X, Mitroulis I, Chavakis T. Trained Innate immunity and its implications for mucosal immunity and inflammation. Adv Exp Med Biol 2019; 1197: 11-26.
[http://dx.doi.org/10.1007/978-3-030-28524-1_2] [PMID: 31732931]
[2]
Doherty PC, Turner SJ. The challenge of viral immunity. Immunity 2007; 27(3): 363-5.
[http://dx.doi.org/10.1016/j.immuni.2007.08.011] [PMID: 17892844]
[3]
Immunity, From: Encyclopedia of Biomedical Engineering. 2019. Available from: https://www.sciencedirect.com/topics/medicine-and-dentistry/immunity
[4]
Y.T Acharya, Charaka Samhita, repr., Sutrasthana Chapter 28, verse 7, Chakprani commentary, Chaukhamba Orientalia, Varanasi. In: 2007.
[5]
Monier Williams A. Sanskrit - English Dictionary. Motilala Banarasidass Publishers Private Limited 2011.
[6]
Y.T Acharya, Charaka Samhita, repr., Sutrasthana Chapter 11, verse 36, Chaukhamba Orientalia, Varanasi. In: 2007.
[7]
Y.T. Acharya and Narayana Ram Acharya Kavyatirtha Sushruta Samhita, repr., Sutrasthana, Chapter 6, Sutra 15, Chaukhambha Surabharati Prakashana, Varanasi. In: 2008.
[8]
Y.T. Acharya and Narayana Ram Acharya Kavyatirtha Sushruta Samhita, repr., Sutrasthana, Chapter 15, Sutra 28, Chaukhambha Surabharati Prakashana, Varanasi In: 2008.
[9]
Y.T Acharya, Charaka Samhita, repr., Chikitsasthana Chapter 15, verse 3-4, Chaukhamba Orientalia, Varanasi. In: 2007.
[10]
Y.T Acharya, Charaka Samhita, repr., Vimanasthana Chapter 4, verse 8, Chakprani commentary, Chaukhamba Orientalia, Varanasi. In: 2007.
[11]
Y.T Acharya, Charaka Samhita, repr., Vimanasthana Chapter 8, verse 94, Chaukhamba Orientalia, Varanasi. In: 2007.
[12]
Y.T Acharya, Charaka Samhita, repr., Chikitsasthana Chapter 8, verse 42, Chaukhamba Orientalia, Varanasi. In: 2007.
[13]
H.S. Shastri Paradakara, AsthangaHridaya of Vagbhata, repr-Chikitsasthana, Chap-1, Sutra-2, Arunadatta commentary, ChaukhambhaSurabharatiPrakashana. In:
[14]
H.S. Shastri Paradakara, AsthangaHridaya of Vagbhata, repr-Nidanasthana, Chap-16, Sutra-56, Arunadatta commentary, ChaukhambhaSurabharatiPrakashana. In:
[15]
Y.T Acharya, Charaka Samhita, repr., Sutrasthana Chapter 17, verse 117, Chaukhamba Orientalia, Varanasi. In: 2007.
[16]
Y.T. Acharya and Narayana Ram Acharya KavyatirthaSushruta Samhita, repr., Sutrasthana, Chapter 15, Sutra 19, ChaukhambhaSurabharatiPrakashana, Varanasi. In: 2008.
[17]
Y.T Acharya, Charaka Samhita, repr., Sharirasthana Chapter 6, verse 13, Chaukhamba Orientalia, Varanasi. In: 2007.
[18]
Y.T Acharya, Charaka Samhita, repr., Chikitsasthana Chapter 6, verse 8, Chaukhamba Orientalia, Varanasi. In: 2007.
[19]
Y.T. Acharya and Narayana Ram Acharya KavyatirthaSushruta Samhita, repr., Sutrasthana, Chapter 15, Sutra 21, ChaukhambhaSurabharatiPrakashana, Varanasi. In: 2008.
[20]
H.S. Shastri Paradakara, AsthangaHridaya of Vagbhata, repr-Sutrasthana, Chap-11, Sutra-39-40, Arunadatta commentary, ChaukhambhaSurabharatiPrakashana. In:
[21]
H.S. Shastri Paradakara, AsthangaHridaya of Vagbhata, repr-Sutrasthahana, Chap-11, Sutra-41, Arunadatta commentary, ChaukhambhaSurabharatiPrakashana. In:
[22]
Y.T. Acharya and Narayana Ram Acharya KavyatirthaSushruta Samhita, repr., Sutrasthana, Chapter 15, Sutra 24, ChaukhambhaSurabharatiPrakashana, Varanasi. In: 2008.
[23]
H.S. Shastri Paradakara, Asthanga Hridaya of Vagbhata, repr- Sutrasthahana, Chap-11, Sutra-39-40, Arunadatta commentary, Chaukhambha Surabharati Prakashana. In:
[24]
Y.T Acharya, Charaka Samhita, repr., Nidanasthana Chapter 4, verse 4, Chaukhamba Orientalia, Varanasi. In: 2007.
[25]
H.S. Shastri Paradakara, AsthangaHridaya of Vagbhata, repr- Sutrasthana, Chap-2 Arunadatta commentary, ChaukhambhaSurabharatiPrakashana. In:
[26]
H.S. Shastri Paradakara, AsthangaHridaya of Vagbhata, repr- Sutrasthana, Chap-3 Arunadatta commentary, ChaukhambhaSurabharatiPrakashana. In:
[27]
Y.T Acharya, Charaka Samhita, repr., Sutrasthana Chapter 8, verse 18-29, Chaukhamba Orientalia, Varanasi. In: 2007.
[28]
H.S. Shastri Paradakara, AsthangaHridaya of Vagbhata, repr- Sutrasthana, Chap-4 Arunadatta commentary, ChaukhambhaSurabharatiPrakashana. In:
[29]
Y.T Acharya, Charaka Samhita, repr., Sutrasthana Chapter 7, verse 26-29, Chaukhamba Orientalia, Varanasi. In: 2007.
[30]
Y.T Acharya, Charaka Samhita, repr., Sutrasthana Chapter 11, verse 35, Chaukhamba Orientalia, Varanasi. In: 2007.
[31]
Y.T Acharya, Charaka Samhita, repr., Vimanasthana Chapter 1, verse 21-25, Chaukhamba Orientalia, Varanasi. In: 2007.
[32]
Y.T Acharya, Charaka Samhita, repr., Sutrasthana Chapter 7, verse 46, Chaukhamba Orientalia, Varanasi. In: 2007.
[33]
Y.T Acharya, Charaka Samhita, repr., Sutrasthana Chapter 7, verse 48-50, Chaukhamba Orientalia, Varanasi. In: 2007.
[34]
Y.T Acharya, Charaka Samhita, repr., Chikitsasthana Chapter 1, Prathama Paada, verse 7-8, Chaukhamba Orientalia, Varanasi. In: 2007.
[35]
Y.T Acharya, Charaka Samhita, repr., Chikitsasthana Chapter 1, Chaturtha Paada, verse 30-35, Chaukhamba Orientalia, Varanasi. In: 2007.
[36]
Y.T Acharya, Charaka Samhita, repr., Chikitsasthana Chapter 15, Chaturtha Paada, verse 3-4, Chaukhamba Orientalia, Varanasi. In: 2007.
[37]
Y.T Acharya, Charaka Samhita, repr., Sutrasthana Chapter 25, verse 31, Chaukhamba Orientalia, Varanasi. In: 2007.
[38]
Tale PR. A critical review of Bal Samskara and its scientific importance. J Ayurveda Integr Med Sci 2020; 6: 152-8.
[39]
Y.T. Acharya and Narayana Ram Acharya Kavyatirtha Sushruta Samhita, repr., Uttaratantra, Chapter 1, Sutra 25, Chaukhambha Surabharati Prakashana, Varanasi. In: 2008.
[40]
Y.T. Acharya and Narayana Ram Acharya Kavyatirtha Sushruta Samhita, repr., Uttaratantra, Chapter 39, Sutra 42, Chaukhambha Surabharati Prakashana, Varanasi. In: 2008.
[41]
Y.T Acharya, Charaka Samhita, repr., Chikitsasthana Chapter 16, verse 4-6, Chaukhamba Orientalia, Varanasi. In: 2007.
[42]
Y.T Acharya, Charaka Samhita, repr., Chikitsasthana Chapter 16, verse 28-29, Chaukhamba Orientalia, Varanasi. In: 2007.
[43]
Y.T Acharya, Charaka Samhita, repr., Chikitsasthana Chapter 8, verse 47, Chaukhamba Orientalia, Varanasi. In: 2007.
[44]
Y.T Acharya, Charaka Samhita, repr., Chikitsasthana Chapter 4, verse 25, Chaukhamba Orientalia, Varanasi. In: 2007.
[45]
Y.T Acharya, Charaka Samhita, repr., Chikitsasthana Chapter 8, verse 41-42, Chaukhamba Orientalia, Varanasi. In: 2007.
[46]
H.S. Shastri Paradakara, Asthanga Hridaya of Vagbhata, repr- Sutrasthana, Chap-1, verse-6 Arunadatta commentary, Chaukhambha Surabharati Prakashana. In:
[47]
[48]
Davison G, Kehaya C, Wyn Jones A. Nutritional and physical activity interventions to improve immunity. Am J Lifestyle Med 2014; 10(3): 152-69.
[http://dx.doi.org/10.1177/1559827614557773]
[49]
Childs CE, Calder PC, Miles EA. Diet and Immune Function. Nutrients 2019; 11(8): 1933.
[http://dx.doi.org/10.3390/nu11081933] [PMID: 31426423]
[50]
Y.T Acharya, Charaka Samhita, repr., Sutrasthana Chapter 28, verse 7, Chaukhamba Orientalia, Varanasi. In: 2007.
[51]
Singh N, Singh SP, Nath C, Kohli RP, Bhargava KP. Anti-stress plants as anti-rheumatic agents 1984.
[52]
Bargale Sushant S, Shashirekha HK. Anti-Aging effect of amalakirasayana in healthy elderly subjects. Journal of Ayurveda and Holistic Medicine 2014; 2(1): 10-8.
[53]
Priyadarshini S, Ashadevi JS, Nagarjun V, Prasanna KS. Increase in Drosophila melanogaster longevity due to Rasayana diet: Preliminary results. Journal of Ayurveda & Integrative Medicine 2010; 1(2): 114-9.
[54]
Pankaj Pathak BR. The effect of Emblica, officinalis diet on lifespan, sexual behavior, and fitness characters in Drosophila melanogaster. AYU 2011; 32(2): 279-84.
[55]
Sai Ram M, Neetu D, Yogesh B, et al. Cyto-protective and immunomodulating properties of Amla (Emblica officinalis) on lymphocytes: An in vitro study. J Ethnopharmacol 2002; 81(1): 5-10.
[http://dx.doi.org/10.1016/S0378-8741(01)00421-4] [PMID: 12020921]
[56]
Ghosal S, Tripathi VK, Chauhan S. Active constituents of Emblica officinalis. Part1. Indian Journal of Chemistry Section B-Organic Chemistry Including Medicinal Chemistry 1996; 35: 941-8.
[57]
Mathur R, Sharma A, Dixit VP, Varma M. Hypolipidaemic effect of fruit juice of Emblica officinalis in cholesterol-fed rabbits. J Ethnopharmacol 1996; 50(2): 61-8.
[http://dx.doi.org/10.1016/0378-8741(95)01308-3] [PMID: 8866725]
[58]
Gulati RK, Agarwal S, Agrawal SS. Hepatoprotective studies on Phyllanthus emblica Linn. and quercetin. Indian J Exp Biol 1995; 33(4): 261-8.
[PMID: 7558182]
[59]
Ayurvedic formulations as therapeutic radioprotectors: Preclinical studies on Brahma Rasayana and Chyavanaprash. Curr Sci 2013; 104(7-10): 959-66.
[60]
Abbas SS, Singh N. Anti-stress Agents (Herbs) of Indian Origin - Herbal Drugs, A twenty first, century perspective Delhi: Institute of Nuclear Medicine and Allied Sciences, Defence Research and Development Organization (DRDO), Govt of India. 2006.
[61]
Kalsi R, Singh N, Gupta GP. Physiology of Human Performance Delhi: Defence Institute of Physiology and Allied Sciences, Defence Research and Development Organization (DRDO), Govt of India; 1987 Effects of stress and anti-stress drugs on succinate dehydrogenase enzyme (SDH) in rat brain (A possible role of SDH in stress adaptation phenomenon). 1987; p. 114-7.
[62]
Singh N, Agarwal AK, Lata A, Kohli RP. Evaluation of ‘adaptogenic’ properties of Withaniasomnifera. Proc Indian Pharmacological Society 1976; p. 17.
[63]
Sumanran VN, Boddul S, Madhuri D. Differential growth inhibitory effects of Withaniasomnifera root on CHO cells. Phytother Res 2007; 21: 1-4.
[64]
Bhattacharya SK, Kumar A, Ghosal S. Effects of glycowithanolides fromWithania somnifera on an animal model of Alzheimer’s disease and perturbed central cholinergic markers of cognition in rats. Phytother Res 1995; 9(2): 110-3.
[http://dx.doi.org/10.1002/ptr.2650090206]
[65]
Singh N, Nath R, Lata A, Singh SP, Kohli RP, Bhargava KP. Withaniasomnifera (Ashwagandha) A rejuvenator herbal drug which enhances survival during stress (An adaptogen). Int J Crude Drug Res 1982; 20(1): 29-35.
[http://dx.doi.org/10.3109/13880208209083282]
[66]
Abdel-Magied EM, Abdel-Rahman HA, Harraz FM. The effect of aqueous extracts of Cynomorium coccineum and Withania somnifera on testicular development in immature Wistar rats. J Ethnopharmacol 2001; 75(1): 1-4.
[http://dx.doi.org/10.1016/S0378-8741(00)00348-2] [PMID: 11282435]
[67]
Budhiraja RD, Sudhir S. Review of biological activity of withanolides. JSIR 1987; 46: 488-91.
[68]
Immune system and antioxidant, especially those derived from Indian from Indian medicinal plant. Indian J Exp Biol 2002; 40: 639.
[PMID: 12587713]
[69]
Brahmi (Bacopa monnieri) and Mandookparni (Centella asiatica). Ayu 2011; 32(2): 258-64.
[70]
Singh RH, Narsimhamurthy K, Singh G. Neuronutrient impact of Ayurvedic Rasayana therapy in brain aging. Biogerontology 2008; 9(6): 369-74.
[http://dx.doi.org/10.1007/s10522-008-9185-z] [PMID: 18931935]
[71]
The in vitro antioxidant activity and total phenolic content of four Indian medicinal plants. Int J Pharm Pharm Sci 2009; 1: 88-95.
[72]
Shivakumar H, Talha Javed T. Prakash, R. Nagendra Rao, B. H. M. Jayakumar Swamy, A. Veerana Goud, Adaptogenic activity of ethanolic extract of Tribulus terrestris L. J Nat Rem 2006; 6(1): 87-95.
[73]
Effects of Medhya Rasayana and Yogic practices in improvement of short-term memory among school- going children. Ayu 2013; 34(4): 383-9.
[74]
Katiyar CK, Brindavanam NB. Immunomodulator product from Ayurveda: current status and future perspective. In: Upadhyay SN, Ed. Immunomodulation. New Delhi, India: Narosa Publishing House 1997; p. 163.
[75]
Clement F, Pramod SN, Venkatesh YP. Identity of the immunomodulatory proteins from garlic (Allium sativum) with the major garlic lectins or agglutinins. Int Immunopharmacol 2010; 10(3): 316-24.
[http://dx.doi.org/10.1016/j.intimp.2009.12.002] [PMID: 20004743]
[76]
Eur J Immunol 1996; 26: 1647-51.
[77]
Bone K. A Clinical Guide to Blending Liquid Herbs Elsevier. UK: Churchill Livingstone 2003.
[78]
Barbosa NR, Pittella F, Gattaz WF. Centella asiatica water extract inhibits iPLA2 and cPLA2 activities in rat cerebellum. Phytomedicine 2008; 15(10): 896-900.
[http://dx.doi.org/10.1016/j.phymed.2008.02.007]
[79]
Bhatnagar M, Sisodia SS, Bhatnagar R. Antiulcer and antioxidant activity of Asparagus racemosus Willd and Withania somnifera Dunal in rats. Ann N Y Acad Sci 2005; 1056(1): 261-78.
[http://dx.doi.org/10.1196/annals.1352.027] [PMID: 16387694]
[80]
Sairam K, Priyambada S, Aryya NC, Goel RK. Gastroduodenal ulcer protective activity of Asparagus racemosus: an experimental, biochemical and histological study. J Ethnopharmacol 2003; 86(1): 1-10.
[http://dx.doi.org/10.1016/S0378-8741(02)00342-2] [PMID: 12686434]
[81]
Oganesyan KR. Antioxidant effect of licorice root on blood catalase activity in vibration stress. Bull Exp Biol Med 2002; 134(2): 135-6.
[http://dx.doi.org/10.1023/A:1021123928740] [PMID: 12459833]
[82]
Mona N. In vivo study of antimutagenic and antioxidant activity of Glycyrrihza glabra root extract. Res Pharma 2012; 2(2): 27-34.
[83]
Sunil MA, Sunitha VS, Radhakrishnan EK, Jyothis M. Immunomodulatory activities of Acacia catechu, a traditional thirst quencher of South India. J Ayurveda Integr Med 2019; 10(3): 185-91.
[http://dx.doi.org/10.1016/j.jaim.2017.10.010]
[84]
Vinothapooshan G, Sundar K. Immunomodulatory activity of various extracts of Adhatoda vasica Linn. in experimental rats. Afr J Pharm Pharmacol 2011; 5(3): 306-10.
[http://dx.doi.org/10.5897/AJPP10.126]
[85]
Patel P, Asdaq SMB. Immunomodulatory activity of methanolic fruit extract of Aegle marmelos in experimental animals. Saudi Pharm J 2010; 18(3): 161-5.
[http://dx.doi.org/10.1016/j.jsps.2010.05.006] [PMID: 23964175]
[86]
Wang T, Liu B, Zhang W, Wilson B, Hong JS. Andrographolide reduces inflammation-mediated dopaminergic neurodegeneration in mesencephalic neuron-glia cultures by inhibiting microglial activation. J Pharmacol Exp Ther 2004; 308(3): 975-83.
[http://dx.doi.org/10.1124/jpet.103.059683] [PMID: 14718612]
[87]
Chandrasekaran C, Sundarajan K, Edwin J, Gururaja G, Mundkinajeddu D, Agarwal A. Immune-stimulatory and anti-inflammatory activities of Curcuma longa extract and its polysaccharide fraction. Pharmacognosy Res 2013; 5(2): 71-9.
[http://dx.doi.org/10.4103/0974-8490.110527] [PMID: 23798880]
[88]
Mangathayaru K, Umadevi M, Reddy CU. Evaluation of the immunomodulatory and DNA protective activities of the shoots of Cynodon dactylon. J Ethnopharmacol 2009; 123(1): 181-4.
[http://dx.doi.org/10.1016/j.jep.2009.02.036] [PMID: 19429359]
[89]
Majdalawieh AF, Hmaidan R, Carr RI. Nigella sativa modulates splenocyte proliferation, Th1/Th2 cytokine profile, macrophage function and NK anti-tumor activity. J Ethnopharmacol 2010; 131(2): 268-75.
[http://dx.doi.org/10.1016/j.jep.2010.06.030] [PMID: 20600757]
[90]
Goel A, Singh DK, Kumar S, Bhatia AK. Immunomodulating property of Ocimum sanctum by regulating the IL-2 production and its mRNA expression using rat’s splenocytes. Asian Pacific Journal of Tropical Medicine 2010; 3(1): 8-12.
[http://dx.doi.org/10.1016/S1995-7645(10)60021-1]
[91]
Li J, Li QW, Gao DW, Han ZS, Lu WZ. Antitumor and immunomodulating effects of polysaccharides isolated from Solanum nigrum Linne. Phytother Res 2009; 23(11): 1524-30.
[http://dx.doi.org/10.1002/ptr.2769] [PMID: 19449342]
[92]
Ganta KK, Mandal A, Debnath S, Hazra B, Chaubey B. Anti-HCV Activity from Semi-purified Methanolic Root Extracts of Valeriana wallichii. Phytother Res 2017; 31(3): 433-40.
[http://dx.doi.org/10.1002/ptr.5765] [PMID: 28078810]
[93]
Lad H, Joshi A, Dixit D, Sharma H, Bhatnagar D. Antioxidant, genoprotective and immunomodulatory potential of Vitex negundo leaves in experimental arthritis. Orient Pharm Exp Med 2016; 16(3): 217-24.
[http://dx.doi.org/10.1007/s13596-016-0234-x]
[94]
Rasool M, Varalakshmi P. Immunomodulatory role of Withania somnifera root powder on experimental induced inflammation: An in vivo and in vitro study. Vascul Pharmacol 2006; 44(6): 406-10.
[http://dx.doi.org/10.1016/j.vph.2006.01.015] [PMID: 16713367]
[95]
Zhou J, Guo F, Fu J, Xiao Y, Wu J. In vitro polyploid induction using colchicine for Zingiber Officinale Roscoe cv. ‘Fengtou’ ginger. Plant Cell Tissue Organ Cult 2020; 142(1): 87-94.
[http://dx.doi.org/10.1007/s11240-020-01842-1]
[96]
Gaikwad SB, Krishna Mohan G. Investigation of immunomodulatory potential of Abutilon indicum Linn. Leaves. Int J Pharmacol Res 2012.
[97]
Narayan C, Kumar A. Antineoplastic and immunomodulatory effect of polyphenolic components of Achyranthes aspera (PCA) extract on urethane induced lung cancer in vivo. Mol Biol Rep 2014; 41(1): 179-91.
[http://dx.doi.org/10.1007/s11033-013-2850-6] [PMID: 24190493]
[98]
Im SA, Lee YR, Lee YH, et al. In vivo evidence of the immunomodulatory activity of orally administered Aloe vera gel. Arch Pharm Res 2010; 33(3): 451-6.
[http://dx.doi.org/10.1007/s12272-010-0315-1] [PMID: 20361311]
[99]
Iwo MI, Soemardji AA, Retnoningrum DS, Sukrasno U UM. Immunostimulating effect of pule (Alstonia scholaris L. R.Br., Apocynaceae) bark extracts. Clin Hemorheol Microcirc 2000; 23(2-4): 177-83.
[PMID: 11321438]
[100]
Sadekar RD, Kolte AY, Barmase BS, Desai VF. Immunopotentiating effects of Azadirachta indica (Neem) dry leaves powder in broilers, naturally infected with IBD virus. Indian J Exp Biol 1998; 36(11): 1151-3.
[PMID: 10085786]
[101]
Yan YQ, Fu YJ, Wu S, et al. Anti-influenza activity of berberine improves prognosis by reducing viral replication in mice. Phytother Res 2018; 32(12): 2560-7.
[http://dx.doi.org/10.1002/ptr.6196] [PMID: 30306659]
[102]
Soumaya KJ, Dhekra M, Fadwa C, et al. Pharmacological, antioxidant, genotoxic studies and modulation of rat splenocyte functions by Cyperus rotundus extracts. BMC Complement Altern Med 2013; 13(1): 28.
[http://dx.doi.org/10.1186/1472-6882-13-28] [PMID: 23388107]
[103]
Mitra Mazumder P, Pattnayak S, Parvani H, Sasmal D, Rathinavelusamy P. Evaluation of immunomodulatory activity of Glycyrhiza glabra L roots in combination with zing. Asian Pac J Trop Biomed 2012; 2(1): S15-20.
[http://dx.doi.org/10.1016/S2221-1691(12)60122-1]
[104]
Orhan IE, Mesaik MA, Jabeen A, Kan Y. Immunomodulatory properties of various natural compounds and essential oils through modulation of human cellular immune response. Ind Crops Prod 2016; 81(1): 117-22.
[http://dx.doi.org/10.1016/j.indcrop.2015.11.088]
[105]
Mahamat O, Flora H, Tume C, Kamanyi A. Immunomodulatory activity of momordica charantia L. (Cucurbitaceae) leaf diethyl ether and methanol extracts on Salmonella typhi -infected mice and LPS-induced phagocytic activities of macrophages and neutrophils. Evid Based Complement Alternat Med 2020; 2020: 1-11.
[http://dx.doi.org/10.1155/2020/5248346] [PMID: 32256648]
[106]
Sharma ML, Rao CS, Duda PL. Immunostimulatory activity of Picrorhiza kurroa leaf extract. J Ethnopharmacol 1994; 41(3): 185-92.
[http://dx.doi.org/10.1016/0378-8741(94)90031-0] [PMID: 8176958]
[107]
Tripathi DM, Gupta N, Lakshmi V, Saxena KC, Agrawal AK. Antigiardial and immunostimulatory effect ofPiper longum on giardiasis due toGiardia lamblia. Phytother Res 1999; 13(7): 561-5.
[http://dx.doi.org/10.1002/(SICI)1099-1573(199911)13:7<561:AID-PTR479>3.0.CO;2-W] [PMID: 10548746]
[108]
Majdalawieh AF, Carr RI. In vitro investigation of the potential immunomodulatory and anti-cancer activities of black pepper (Piper nigrum) and cardamom (Elettaria cardamomum). J Med Food 2010; 13(2): 371-81.
[http://dx.doi.org/10.1089/jmf.2009.1131] [PMID: 20210607]
[109]
Muniandy K, Gothai S, Badran KMH, Suresh Kumar S, Esa NM, Arulselvan P. Suppression of proinflammatory cytokines and mediators in LPS-Induced RAW 264.7 macrophages by stem extract of alternanthera sessilis via the inhibition of the NF-κB pathway. J Immunol Res 2018; 2018: 1-12.
[http://dx.doi.org/10.1155/2018/3430684] [PMID: 30155492]
[110]
Labsi M, Khelifi L, Mezioug D, Soufli I, Touil-Boukoffa C. Antihydatic and immunomodulatory effects of Punica granatum peel aqueous extract in a murine model of echinococcosis. Asian Pac J Trop Med 2016; 9(3): 211-20.
[http://dx.doi.org/10.1016/j.apjtm.2016.01.038] [PMID: 26972390]
[111]
Gupta A, Chaphalkar SR. Immunopharmacological screening of aqueous root extract of Santalum album. J HerbMed Pharmacol 2016; 5(1): 7-11.
[112]
Chen HC, Chou CK, Lee SD, Wang JC, Yeh SF. Active compounds from Saussurea lappa Clarks that suppress hepatitis B virus surface antigen gene expression in human hepatoma cells. Antiviral Res 1995; 27(1-2): 99-109.
[http://dx.doi.org/10.1016/0166-3542(94)00083-K] [PMID: 7486962]
[113]
Dibazar SP, Fateh S, Daneshmandi S. Immunomodulatory effects of clove (Syzygium aromaticum) constituents on macrophages: In vitro evaluations of aqueous and ethanolic components. J Immunotoxicol 2015; 12(2): 124-31.
[http://dx.doi.org/10.3109/1547691X.2014.912698] [PMID: 24873744]
[114]
Shivaprasad HN, Kharya MD, Rana AC, Mohan S. Preliminary immunomodulatory activities of the aqueous extract of Terminalia chebula. Pharm Biol 2006; 44(1): 32-4.
[http://dx.doi.org/10.1080/13880200500530542]
[115]
Alsuhaibani S, Khan MA. Immune-stimulatory and therapeutic activity of tinospora cordifolia: double-edged sword against salmonellosis. J Immunol Res 2017; 2017: 1-9.
[http://dx.doi.org/10.1155/2017/1787803] [PMID: 29318160]
[116]
Anita Tilwari, Shukla NP, Uma Devi P. Effect of five medicinal plants used in Indian system of medicines on immune function in Wistar rats. Afr J Biotechnol 2011; 10(73): 16637-45.
[http://dx.doi.org/10.5897/AJB10.2168]
[117]
Hong EH, Song JH, Kang KB, Sung SH, Ko HJ, Yang H. Anti-influenza activity of betulinic acid from Zizyphus Jujuba on influenza A/PR/8 virus. Biomol Ther (Seoul) 2015; 23(4): 345-9.
[http://dx.doi.org/10.4062/biomolther.2015.019] [PMID: 26157551]
[118]
Han X, Parker TL. Cardamom (Elettaria cardamomum) essential oil significantly inhibits vascular cell adhesion molecule 1 and impacts genome-wide gene expression in human dermal fibroblasts. Cogent Med 2017; 4(1): 1308066.
[http://dx.doi.org/10.1080/2331205X.2017.1308066]
[119]
Uttara J, Mishra SH. Preliminary evaluation of immunomodulatory and antistress activity of methanol extract of Hedychium spicatum. Pharmacologyonline 2009; 1: 1057-71.
[120]
Mishra A, Thakur M, Alok S. Evaluation of immunomodulatory activity of polysacchride fraction of Inula racemosa, Bombax ceiba and Allium sativum. Int J Pharm Sci Res 2016; 7(9): 3749-55.
[http://dx.doi.org/10.13040/IJPSR.0975-8232]
[121]
Daoudi A, Aarab L, Abdel-Sattar E. Screening of immunomodulatory activity of total and protein extracts of some Moroccan medicinal plants. Toxicol Ind Health 2013; 29(3): 245-53.
[http://dx.doi.org/10.1177/0748233711430972] [PMID: 22301818]
[122]
Murthy K, Mishra SH. Velvet bean roots stimulates humoral and cell mediated immunity and offers protection against cyclophosphamide induced myelosuppression. Int J Phytomed 2016; 8(1): 69-79.
[123]
Khorrami S, Daneshmandi S, Mosayebi G. Sesame seeds essential oil and Sesamol modulate the pro-inflammatory function of macrophages and dendritic cells and promote Th2 response. Med J Islam Repub Iran 2018; 32(1): 566-73.
[http://dx.doi.org/10.14196/mjiri.32.98] [PMID: 30788333]
[124]
Tekade SH, Mode SG, Waghmare SP. Effect of Asparagus racemosus, Sida cordifolia and levamisole on immunological parameters in experimentally induced immunosuppressed broilers. Vet World 2008; 1(2): 49-50.
[125]
Shruthi RR, Venkatesh YP, Muralikrishna G. Structural and functional characterization of a novel immunomodulatory glycoprotein isolated from ajowan (Trachyspermum ammi L.). Glycoconj J 2017; 34(4): 499-514.
[http://dx.doi.org/10.1007/s10719-017-9771-x] [PMID: 28493026]
[126]
Vayalil PK, Kuttan G, Kuttan R. Protective effects of Rasayanas on cyclophosphamide- and radiation-induced damage. J Altern Complement Med 2002; 8(6): 787-96.
[http://dx.doi.org/10.1089/10755530260511801] [PMID: 12614532]
[127]
Dar NJ, Hamid A, Ahmad M. Pharmacologic overview of Withania somnifera, the Indian Ginseng. Cell Mol Life Sci 2015; 72(23): 4445-60.
[http://dx.doi.org/10.1007/s00018-015-2012-1] [PMID: 26306935]
[128]
Singh G, Sharma PK, Dudhe R, Singh S. Biological activities of withaniasomnifera. Ann Biol Res 2010; 1: 56-63.
[129]
Joseph CD, Praveenkumar V, Kuttan G, Kuttan R. Myeloprotective effect of a non-toxic indigenous preparation Rasayana in cancer patients receiving chemotherapy and radiation therapy. A pilot study. J Exp Clin Cancer Res 1999; 18(3): 325-9.
[PMID: 10606177]
[130]
Satyamoorthy K, Guruprasad KP, Mascarenhas R, Gopinath PM. Studies on Brahma rasayana in male swiss albino mice: Chromosomal aberrations and sperm abnormalities. J Ayurveda Integr Med 2010; 1(1): 40-4.
[http://dx.doi.org/10.4103/0975-9476.59826] [PMID: 21829300]
[131]
Jose JK, Kuttan R. Hepatoprotective activity of Emblica officinalis and Chyavanaprash. J Ethnopharmacol 2000; 72(1-2): 135-40.
[http://dx.doi.org/10.1016/S0378-8741(00)00219-1] [PMID: 10967464]
[132]
Yadav JS, Thakur S, Chadha P. Chyawanprash Awaleha: A genoprotective agent for bidi smokers internal. Journal of Human Genetics 2003; 3(1): 33-8.
[133]
Anil M, Suresh P. Determination of free radical scavenging activity in herbal supplement: chyawanprash. Int J Drug Dev Res 2011; 3(1): 328-33.
[134]
Sastry JLN, Gupta A, Brindavanam NB, Kanjilal S, Kumar S, Setia M, et al. Quantification of immunity status of dabur Chyawanprash - a review part- 2 (clinical studies). Indian J Appl Res 2011; 4(3): 205-11.
[http://dx.doi.org/10.15373/2249555X/MAR2014/61]
[135]
Singh K. Concept of Ojas and the effect of Rasayanas in the management of cancer. Proceedings of Ayurveda Seminar on Cancer. Thrissur, India. 1990; pp. 15-8.
[136]
Belapurkar P, Goyal P, Tiwari-Barua P. Immunomodulatory effects of triphala and its individual constituents: a review. Indian J Pharm Sci 2014; 76(6): 467-75.
[PMID: 25593379]
[137]
Singh R, Goel S, Bourgeade P, Aleya L, Tewari D. Ayurveda Rasayana as antivirals and immunomodulators: potential applications in COVID-19. Environ Sci Pollut Res Int 2021; 28(40): 55925-51.
[http://dx.doi.org/10.1007/s11356-021-16280-5] [PMID: 34491498]
[138]
Galib, Patgiri BJ, Prajapati PK, Ravishankar B, Rajani J, Ashok BK. Immunomodulatory activity of Āmalaki Rasāyana: An experimental evaluation. Anc Sci Life 2012; 32(2): 93-8.
[http://dx.doi.org/10.4103/0257-7941.118546] [PMID: 24167334]
[139]
Guruprasad KP, Dash S, Shivakumar MB, et al. Influence of Amalaki Rasayana on telomerase activity and telomere length in human blood mononuclear cells. J Ayurveda Integr Med 2017; 8(2): 105-12.
[http://dx.doi.org/10.1016/j.jaim.2017.01.007] [PMID: 28602428]
[140]
Agrawal AK, Tripathi DM, Sahai R, et al. Management of Giardiasis by a herbal drug ‘Pippali Rasayana’: a clinical study. J Ethnopharmacol 1997; 56(3): 233-6.
[http://dx.doi.org/10.1016/S0378-8741(97)00037-8] [PMID: 9201614]
[141]
Gupta GD, Sujatha N, Dhanik A, Rai NP. Clinical evaluation of Shilajatu Rasayana in patients with HIV infection. Ayu 2010; 31(1): 28-32.
[http://dx.doi.org/10.4103/0974-8520.68205] [PMID: 22131681]
[142]
WHO Director-General’s opening remarks at the media briefing on COVID19, WHO characterizes COVID-19 as a pandemic. 2020. Available from: https://www.who.int/emergencies/diseases/novel-coronavirus-2019/events-as-they-happen
[143]
Gorbalenya AE, Baker SC, Baric RS, et al. The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2. Nat Microbiol 2020; 5(4): 536-44.
[http://dx.doi.org/10.1038/s41564-020-0695-z] [PMID: 32123347]
[144]
Ahmad S, Zahiruddin S, Parveen B, et al. Indian Medicinal Plants and Formulations and Their Potential Against COVID-19–Preclinical and Clinical Research. Front Pharmacol 2021; 11: 578970.
[http://dx.doi.org/10.3389/fphar.2020.578970] [PMID: 33737875]
[145]
An ethnobotanical review on medicinal plants of the Lamiaceae family in Turkey. Turk J Bot 2022; 46(4): 1.
[146]
Singh RH. The Contemporary Strength of Ayurvedic Geriatrics. Annals of Ayurvedic Medicine 2012; 1(1): 22-30.

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy