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Current Diabetes Reviews

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ISSN (Print): 1573-3998
ISSN (Online): 1875-6417

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Review Article

Tachykinins Play a Major Role in Micro and Macrovascular Complications in Type 2 Diabetes Patients

Author(s): Faiqah Ramzan, Laila Kiran, Shumaila Noreen Malik and Muhammad Inamullah Malik*

Volume 20, Issue 3, 2024

Published on: 13 July, 2023

Article ID: e050523216590 Pages: 5

DOI: 10.2174/1573399819666230505123844

Price: $65

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Abstract

Diabetes Mellitus is a metabolic disorder, which is characterized by an increase in blood glucose levels. The defects in the secretion or action of insulin are the major cause of diabetes. Increase in the blood glucose level exerts a negative effect on the normal functions of the body organs and this leads to the dysfunctions of cells and tissue and causes vascular complications in diabetic patients. Several studies indicate that neuropeptides are released from the neurosensory cells which are mainly known as tachykinins which provoke major vascular complications in diabetic patients. Tachykinins are known as pro-inflammatory peptides which increase vascular complications and vascular permeability. The duration and severity of diabetes disease increase the risk of vascular complication in patients. The aim of this review is to elaborate the role of tachykinins in microvascular and macrovascular complications in diabetic patients. The study concluded that tachykinins increase micro and macrovascular complications in diabetic patients.

Keywords: Diabetes, neuropeptides, neurosensory, tachykinins, vascular complications, neuropeptides.

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