Login Register Cart 0
Research Article

姜黄素和藏红花素对关节炎大鼠炎症反应的联合作用

卷 31, 期 28, 2024

发表于: 07 July, 2023

页: [4562 - 4577] 页: 16

弟呕挨: 10.2174/0929867330666230409003744

价格: $65

Open Access Journals Promotions 2
conference banner
摘要

背景：本研究评价了藏红花素和姜黄素联合应用对大鼠佐剂性关节炎(AIA)的抗关节炎作用。 方法：采用右后爪注射完全弗氏佐剂(CFA)建立大鼠关节炎模型，随后用藏红花素和姜黄素治疗。通过大鼠足跖肿胀、血液学指标、生化指标、炎症因子和组织病理学来评价其抗关节炎活性。 结果：结果显示，与正常组相比，关节炎大鼠足部肿胀增加，血清标志物(CRP、RF、ALP、ALT和AST)水平升高，炎症因子(Il - β和Tnf - α)水平升高，组织学变化(软骨和骨降解)增加。藏红花素、姜黄素、藏红花素+姜黄素不同剂量给药(特别是分别以40 mg/kg和30 mg/kg联合给药)以及MTX对AIA大鼠均有较好的治疗效果。此外，由于植物化学物质具有抗炎作用，不同剂量的植物化学物质及其组合均显示出有效的抗关节炎作用。 结论：藏红花素和姜黄素，单独或联合，可以是一个合适的治疗方式，类风湿关节炎。

关键词: 关节炎，类风湿，藏红花素，姜黄素，完全的朋友的佐剂，炎症细胞因子。

« Previous
[1]
Tastekin, N.; Aydogdu, N.; Dokmeci, D.; Usta, U.; Birtane, M.; Erbas, H.; Ture, M. Protective effects of l-carnitine and alpha-lipoic acid in rats with adjuvant arthritis. Pharmacol. Res., 2007, 56(4), 303-310.
[http://dx.doi.org/10.1016/j.phrs.2007.07.008] [PMID: 17826175]
[2]
Wang, C.; Dai, Y.; Yang, J.; Chou, G.; Wang, C.; Wang, Z. Treatment with total alkaloids from Radix Linderae reduces inflammation and joint destruction in type II collagen-induced model for rheumatoid arthritis. J. Ethnopharmacol., 2007, 111(2), 322-328.
[http://dx.doi.org/10.1016/j.jep.2006.11.031] [PMID: 17204385]
[3]
Vierboom, M.P.M.; Jonker, M.; Tak, P.P.; ’t Hart, B.A. Preclinical models of arthritic disease in non-human primates. Drug Discov. Today, 2007, 12(7-8), 327-335.
[http://dx.doi.org/10.1016/j.drudis.2007.02.012] [PMID: 17395093]
[4]
Guo, Q.; Wang, Y.; Xu, D.; Nossent, J.; Pavlos, N.J.; Xu, J. Rheumatoid arthritis: Pathological mechanisms and modern pharmacologic therapies. Bone Res., 2018, 6(1), 15.
[http://dx.doi.org/10.1038/s41413-018-0016-9] [PMID: 29736302]
[5]
Korani, S.; Korani, M.; Butler, A.E.; Sahebkar, A. Genetics and rheumatoid arthritis susceptibility in Iran. J. Cell. Physiol., 2019, 234(5), 5578-5587.
[http://dx.doi.org/10.1002/jcp.27379] [PMID: 30238988]
[6]
Zhao, J.; Arao, Y.; Sun, S.; Kikuchi, A.; Kayama, F. Oral administration of soy-derived genistin suppresses lipopolysaccharide-induced acute liver inflammation but does not induce thymic atrophy in the rat. Life Sci., 2006, 78(8), 812-819.
[http://dx.doi.org/10.1016/j.lfs.2005.05.104] [PMID: 16257011]
[7]
Smolen, J.S.; Steiner, G. Therapeutic strategies for rheumatoid arthritis. Nat. Rev. Drug Discov., 2003, 2(6), 473-488.
[http://dx.doi.org/10.1038/nrd1109] [PMID: 12776222]
[8]
Cai, X.; Zhou, H.; Wong, Y.F.; Xie, Y.; Liu, Z.Q.; Jiang, Z.H.; Bian, Z.X.; Xu, H.X.; Liu, L. Suppression of the onset and progression of collagen-induced arthritis in rats by QFGJS, a preparation from an anti-arthritic Chinese herbal formula. J. Ethnopharmacol., 2007, 110(1), 39-48.
[http://dx.doi.org/10.1016/j.jep.2006.09.008] [PMID: 17049776]
[9]
Bedoui, Y.; Guillot, X.; Sélambarom, J.; Guiraud, P.; Giry, C.; Jaffar-Bandjee, M.C.; Ralandison, S.; Gasque, P. Methotrexate an old drug with new tricks. Int. J. Mol. Sci., 2019, 20(20), 5023.
[http://dx.doi.org/10.3390/ijms20205023] [PMID: 31658782]
[10]
El-Said, K.S.; Atta, A.; Mobasher, M.A.; Germoush, M.O.; Mohamed, T.M.; Salem, M.M. Quercetin mitigates rheumatoid arthritis by inhibiting adenosine deaminase in rats. Mol. Med., 2022, 28(1), 24.
[http://dx.doi.org/10.1186/s10020-022-00432-5] [PMID: 35193490]
[11]
Feldmann, M.; Maini, R.N.; Bondeson, J.; Taylor, P.; Foxwell, B.M.J.; Brennan, F.M. Cytokine blockade in rheumatoid arthritis. Adv. Exp. Med. Biol., 2001, 490, 119-127.
[http://dx.doi.org/10.1007/978-1-4615-1243-1_13] [PMID: 11505970]
[12]
Rennie, K.L.; Hughes, J.; Lang, R.; Jebb, S.A. Nutritional management of rheumatoid arthritis: A review of the evidence. J. Hum. Nutr. Diet., 2003, 16(2), 97-109.
[http://dx.doi.org/10.1046/j.1365-277X.2003.00423.x] [PMID: 12662368]
[13]
Prasad, S.; Gupta, S.C.; Tyagi, A.K.; Aggarwal, B.B. Curcumin, a component of golden spice: From bedside to bench and back. Biotechnol. Adv., 2014, 32(6), 1053-1064.
[http://dx.doi.org/10.1016/j.biotechadv.2014.04.004] [PMID: 24793420]
[14]
Deogade, S.C.; Ghate, S. Curcumin: Therapeutic applications in systemic and oral health. Int. J. Biol. Pharm. Res., 2015, 6(4), 281-290.
[15]
Goel, A.; Kunnumakkara, A.B.; Aggarwal, B.B. Curcumin as “Curecumin”: From kitchen to clinic. Biochem. Pharmacol., 2008, 75(4), 787-809.
[http://dx.doi.org/10.1016/j.bcp.2007.08.016] [PMID: 17900536]
[16]
Jurenka, J.S. Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: A review of preclinical and clinical research. Altern. Med. Rev., 2009, 14(2), 141-153.
[PMID: 19594223]
[17]
Hasanzadeh, S., Read, M. I., Bland, A. R., Majeed, M., Jamialahmadi, T., Sahebkar, A. Curcumin: An inflammasome silencer. Pharmacological research, 2020, 159, 104921.
[http://dx.doi.org/10.1016/j.phrs.2020.104921]
[18]
Momtazi-Borojeni, A. A., Haftcheshmeh, S. M., Esmaeili, S. A., Johnston, T. P., Abdollahi, E., Sahebkar, A. Curcumin: A natural modulator of immune cells in systemic lupus erythematosus. Autoimmunity reviews, 201817(2), 125–135.
[http://dx.doi.org/10.1016/j.autrev.2017.11.016]
[19]
Mohajeri, M., Sahebkar, A. Protective effects of curcumin against doxorubicin-induced toxicity and resistance: A review. In: Critical reviews in oncology/hematology, 2018, Vol:122, pp. 30-51.
[http://dx.doi.org/10.1016/j.critrevonc.2017.12.005]
[20]
Shakeri, A.; Cicero, A.F.G.; Panahi, Y.; Mohajeri, M.; Sahebkar, A. Curcumin: A naturally occurring autophagy modulator. J. Cell. Physiol., 2019, 234(5), 5643-5654.
[http://dx.doi.org/10.1002/jcp.27404] [PMID: 30239005]
[21]
Afshari, A.R.; Jalili-Nik, M.; Abbasinezhad-Moud, F.; Javid, H.; Karimi, M.; Mollazadeh, H.; Jamialahmadi, T.; Sathyapalan, T.; Sahebkar, A. Anti-tumor effects of curcuminoids in glioblastoma multiforme: An updated literature review. Curr. Med. Chem., 2021, 28(39), 8116-8138.
[http://dx.doi.org/10.2174/1875533XMTExtNDA8x] [PMID: 33176632]
[22]
Mokhtari-Zaer, A., Marefati, N., Atkin, S. L., Butler, A. E., Sahebkar, A. The protective role of curcumin in myocardial ischemia-reperfusion injury. Journal of cellular physiology, 2018, 234(1), 214–222.
[http://dx.doi.org/10.1097/CEJ.0b013e32832c389e]
[23]
Heidari, Z.; Daei, M.; Boozari, M.; Jamialahmadi, T.; Sahebkar, A. Curcumin supplementation in pediatric patients: A systematic review of current clinical evidence. Phytother. Res., 2022, 36(4), 1442-1458.
[http://dx.doi.org/10.1002/ptr.7350] [PMID: 34904764]
[24]
Mohammed, E.; El-Beih, N.; El-Hussieny, E.; El-Ahwany, E.; Hassan, M.; Zoheiry, M. Effects of free and nanoparticulate curcumin on chemically induced liver carcinoma in an animal model. Arch. Med. Sci., 2021, 17(1), 218-227.
[http://dx.doi.org/10.5114/aoms.2020.93739] [PMID: 33488874]
[25]
Iranshahi, M.; Sahebkar, A.; Takasaki, M.; Konoshima, T.; Tokuda, H. Cancer chemopreventive activity of diversin from Ferula diversivittata in vitro and in vivo. Phytomedicine, 2010, 17 (3-4), 269-273.
[http://dx.doi.org/10.1158/0008-5472.CAN-21-1331] [PMID: 35149589]
[26]
Ganji, A., Farahani, I., Saeedifar, A. M., Mosayebi, G., Ghazavi, A., Majeed, M., Jamialahmadi, T., Sahebkar, A. Protective effects of curcumin against lipopolysaccharide-induced toxicity. Curr. Medi. Chem., 2021, 28(33), 6915–6930.
[http://dx.doi.org/10.2174/0929867328666210525124707]
[27]
Hong, J.; Bose, M.; Ju, J.; Ryu, J-H.; Chen, X.; Sang, S.; Lee, M.J.; Yang, C.S. Modulation of arachidonic acid metabolism by curcumin and related -diketone derivatives: Effects on cytosolic phospholipase A2, cyclooxygenases and 5-lipoxygenase. Carcinogenesis, 2004, 25(9), 1671-1679.
[http://dx.doi.org/10.1093/carcin/bgh165] [PMID: 15073046]
[28]
Kahkhaie, K.R.; Mirhosseini, A.; Aliabadi, A.; Mohammadi, A.; Mousavi, M.J.; Haftcheshmeh, S.M.; Sathyapalan, T.; Sahebkar, A. Curcumin: A modulator of inflammatory signaling pathways in the immune system. Inflammopharmacology, 2019, 27(5), 885-900.
[http://dx.doi.org/10.1007/s10787-019-00607-3] [PMID: 31140036]
[29]
Korani, S.; Korani, M.; Sathyapalan, T.; Sahebkar, A. Therapeutic effects of Crocin in autoimmune diseases: A review. Biofactors, 2019, 45(6), 835-843.
[http://dx.doi.org/10.1002/biof.1557] [PMID: 31430413]
[30]
Bhandari, P.R. Crocus sativus L. (saffron) for cancer chemoprevention: A mini review. J. Tradit. Complement. Med., 2015, 5(2), 81-87.
[http://dx.doi.org/10.1016/j.jtcme.2014.10.009] [PMID: 26151016]
[31]
Bolhassani, A.; Khavari, A.; Bathaie, S.Z. Saffron and natural carotenoids: Biochemical activities and anti-tumor effects. Biochim. Biophys. Acta. Rev. Cancer., 2014, 1845(1), 20-30.
[32]
Tamanoi, F.; Bathaie, S.Z. Natural products and cancer signaling: isoprenoids, polyphenols and flavonoids. Academic Press, 2014.
[33]
El-Beshbishy, H.A.; Hassan, M.H.; Aly, H.A.A.; Doghish, A.S.; Alghaithy, A.A.A. Crocin “saffron” protects against beryllium chloride toxicity in rats through diminution of oxidative stress and enhancing gene expression of antioxidant enzymes. Ecotoxicol. Environ. Saf., 2012, 83, 47-54.
[http://dx.doi.org/10.1016/j.ecoenv.2012.06.003] [PMID: 22766413]
[34]
Assimopoulou, A.N.; Sinakos, Z.; Papageorgiou, V.P. Radical scavenging activity of Crocus sativus L. extract and its bioactive constituents. Phytother. Res., 2005, 19(11), 997-1000.
[http://dx.doi.org/10.1002/ptr.1749] [PMID: 16317646]
[35]
Razavi, M.; Hosseinzadeh, H.; Abnous, K.; Motamedshariaty, V.S.; Imenshahidi, M. Crocin restores hypotensive effect of subchronic administration of diazinon in rats. Iran. J. Basic Med. Sci., 2013, 16(1), 64-72.
[PMID: 23638294]
[36]
Amin, A.; Hamza, A.A.; Daoud, S.; Khazanehdari, K.; Hrout, A.A.; Baig, B.; Chaiboonchoe, A.; Adrian, T.E.; Zaki, N.; Salehi-Ashtiani, K. Saffron-based crocin prevents early lesions of liver cancer: In vivo, in vitro and network analyses. Recent Patents Anticancer Drug Discov., 2016, 11(1), 121-133.
[http://dx.doi.org/10.2174/1574892810666151102110248] [PMID: 26522014]
[37]
Li, K.; Li, Y.; Ma, Z.; Zhao, J. Crocin exerts anti-inflammatory and anti-catabolic effects on rat intervertebral discs by suppressing the activation of JNK. Int. J. Mol. Med., 2015, 36(5), 1291-1299.
[http://dx.doi.org/10.3892/ijmm.2015.2359] [PMID: 26648423]
[38]
Zamani Taghizadeh Rabe, S.; Sahebari, M.; Mahmoudi, Z.; Hosseinzadeh, H.; Haghmorad, D.; Tabasi, N.; Rastin, M.; Khazaee, M.; Mahmoudi, M. Inhibitory effect of Crocus sativus L. ethanol extract on adjuvant-induced arthritis. Food Agric. Immunol., 2015, 26(2), 170-180.
[http://dx.doi.org/10.1080/09540105.2013.878900]
[39]
Higashino, S.; Sasaki, Y.; Giddings, J.C.; Hyodo, K.; Fujimoto Sakata, S.; Matsuda, K.; Horikawa, Y.; Yamamoto, J. Crocetin, a carotenoid from Gardenia jasminoides Ellis, protects against hypertension and cerebral thrombogenesis in stroke-prone spontaneously hypertensive rats. Phytother. Res., 2014, 28(9), 1315-1319.
[http://dx.doi.org/10.1002/ptr.5130] [PMID: 24550159]
[40]
Liu, M.; Amini, A.; Ahmad, Z. Safranal and its analogs inhibit Escherichia coli ATP synthase and cell growth. Int. J. Biol. Macromol., 2017, 95, 145-152.
[http://dx.doi.org/10.1016/j.ijbiomac.2016.11.038] [PMID: 27865956]
[41]
Eslami, M.; Bayat, M.; Mozaffari Nejad, A.S.; Sabokbar, A.; Anvar, A.A. Effect of polymer/nanosilver composite packaging on long-term microbiological status of Iranian saffron (Crocus sativus L.). Saudi J. Biol. Sci., 2016, 23(3), 341-347.
[http://dx.doi.org/10.1016/j.sjbs.2015.07.004] [PMID: 27081358]
[42]
Christodoulou, E.; Kadoglou, N.P.E.; Stasinopoulou, M.; Konstandi, O.A.; Kenoutis, C.; Kakazanis, Z.I.; Rizakou, A.; Kostomitsopoulos, N.; Valsami, G. Crocus sativus L. aqueous extract reduces atherogenesis, increases atherosclerotic plaque stability and improves glucose control in diabetic atherosclerotic animals. Atherosclerosis, 2018, 268, 207-214.
[http://dx.doi.org/10.1016/j.atherosclerosis.2017.10.032] [PMID: 29128090]
[43]
Sadeghnia, H.R.; Shaterzadeh, H.; Forouzanfar, F.; Hosseinzadeh, H. Neuroprotective effect of safranal, an active ingredient of Crocus sativus, in a rat model of transient cerebral ischemia. Folia Neuropathol., 2017, 3(3), 206-213.
[http://dx.doi.org/10.5114/fn.2017.70485] [PMID: 28984113]
[44]
Samarghandian, S.; Samini, F.; Azimi-Nezhad, M.; Farkhondeh, T. Anti-oxidative effects of safranal on immobilization-induced oxidative damage in rat brain. Neurosci. Lett., 2017, 659, 26-32.
[http://dx.doi.org/10.1016/j.neulet.2017.08.065] [PMID: 28866053]
[45]
Konstantopoulos, P.; Doulamis, I.; Tzani, A.; Korou, M.L.; Agapitos, E.; Vlachos, I.; Pergialiotis, V.; Verikokos, C.; Mastorakos, G.; Katsilambros, N.; Perrea, D. Metabolic effects of Crocus sativus and protective action against non-alcoholic fatty liver disease in diabetic rats. Biomed. Rep., 2017, 6(5), 513-518.
[http://dx.doi.org/10.3892/br.2017.884] [PMID: 28529733]
[46]
Mashmoul, M.; Azlan, A.; Mohtarrudin, N.; Mohd Yusof, B.N.; Khaza’ai, H.; Khoo, H.E.; Farzadnia, M.; Boroushaki, M.T. Protective effects of saffron extract and crocin supplementation on fatty liver tissue of high-fat diet-induced obese rats. BMC Complement. Altern. Med., 2016, 16(1), 401.
[http://dx.doi.org/10.1186/s12906-016-1381-9] [PMID: 27770798]
[47]
Nader, M.; Chahine, N.; Salem, C.; Chahine, R. Saffron (Crocus sativus) pretreatment confers cardioprotection against ischemia-reperfusion injuries in isolated rabbit heart. J. Physiol. Biochem., 2016, 72(4), 711-719.
[http://dx.doi.org/10.1007/s13105-016-0510-8] [PMID: 27507116]
[48]
Ebadi, M. Pharmacodynamic basis of herbal medicine; CRC press, 2006.
[http://dx.doi.org/10.1201/9781420006452]
[49]
Yaribeygi, H.; Mohammadi, M.T.; Rezaee, R.; Sahebkar, A. Crocin improves renal function by declining Nox-4, IL-18, and p53 expression levels in an experimental model of diabetic nephropathy. J. Cell. Biochem., 2018, 119(7), 6080-6093.
[http://dx.doi.org/10.1002/jcb.26806] [PMID: 29575259]
[50]
Yaribeygi, H.; Mohammadi, M.T.; Sahebkar, A. Crocin potentiates antioxidant defense system and improves oxidative damage in liver tissue in diabetic rats. Biomed. Pharmacother., 2018, 98, 333-337.
[http://dx.doi.org/10.1016/j.biopha.2017.12.077] [PMID: 29274590]
[51]
Zhao, X.; Kim, Y.R.; Min, Y.; Zhao, Y.; Do, K.; Son, Y.O. Natural plant extracts and compounds for rheumatoid arthritis therapy. Medicina, 2021, 57(3), 266.
[http://dx.doi.org/10.3390/medicina57030266] [PMID: 33803959]
[52]
Qi, Y.; Li, S.; Pi, Z.; Song, F.; Lin, N.; Liu, S.; Liu, Z. Metabonomic study of Wu-tou decoction in adjuvant-induced arthritis rat using ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 2014, 953-954, 11-19.
[http://dx.doi.org/10.1016/j.jchromb.2014.01.044] [PMID: 24561351]
[53]
Lü, S.; Wang, Q.; Li, G.; Sun, S.; Guo, Y.; Kuang, H. The treatment of rheumatoid arthritis using Chinese medicinal plants: From pharmacology to potential molecular mechanisms. J. Ethnopharmacol., 2015, 176, 177-206.
[http://dx.doi.org/10.1016/j.jep.2015.10.010] [PMID: 26471289]
[54]
Guo, Q.; Zheng, K.; Fan, D.; Zhao, Y.; Li, L.; Bian, Y.; Qiu, X.; Liu, X.; Zhang, G.; Ma, C.; He, X.; Lu, A. Wu-Tou decoction in rheumatoid arthritis: Integrating network pharmacology and in vivo pharmacological evaluation. Front. Pharmacol., 2017, 8, 230.
[http://dx.doi.org/10.3389/fphar.2017.00230] [PMID: 28515692]
[55]
Yu, T.; Qing, M.; Xiao, W. Study of the regulatory effect of Guizhi-Shaoyao-Zhimu decoction on RA synovial cell apoptosis. Cont Med., 2010, 16, 18-20.
[56]
Liu, W.; Sun, Y.; Cheng, Z.; Guo, Y.; Liu, P.; Wen, Y. Crocin exerts anti-inflammatory and anti-arthritic effects on type II collagen-induced arthritis in rats. Pharm. Biol., 2018, 56(1), 209-216.
[http://dx.doi.org/10.1080/13880209.2018.1448874] [PMID: 29540097]
[57]
Borashan, F.A.; Ilkhanipoor, M.; Hashemi, M.; Farrokhi, F. Investigation the effects of curcumin on serum hepatic enzymes activity in a rheumatoid arthritis model. Electron. J. Biotechnol., 2009, 4(4), 129-133.
[58]
Banji, D.; Pinnapureddy, J.; Banji, O.J.F.; Saidulu, A.; Hayath, M.S. Synergistic activity of curcumin with methotrexate in ameliorating Freund’s complete adjuvant induced arthritis with reduced hepatotoxicity in experimental animals. Eur. J. Pharmacol., 2011, 668(1-2), 293-298.
[http://dx.doi.org/10.1016/j.ejphar.2011.06.006] [PMID: 21693118]
[59]
Nair, V.; Singh, S.; Gupta, Y.K. Evaluation of disease modifying activity of Coriandrum sativum in experimental models. Indian J. Med. Res., 2012, 135(2), 240-245.
[PMID: 22446868]
[60]
Doig, K.; Zhang, B. A methodical approach to interpreting the red blood cell parameters of the complete blood count. Clin. Lab. Sci., 2017, 30(3), 173-185.
[http://dx.doi.org/10.29074/ascls.30.3.173]
[61]
Mehta, A.; Sethiya, N.K.; Mehta, C.; Shah, G.B. Anti–arthritis activity of roots of Hemidesmus indicus R.Br. (Anantmul) in rats. Asian Pac. J. Trop. Med., 2012, 5(2), 130-135.
[http://dx.doi.org/10.1016/S1995-7645(12)60011-X] [PMID: 22221757]
[62]
Patil, K.S.; Suryavanshi, J. Effect of Celastrus paniculatus Willd. seed on adjuvant induced arthritis in rats. Pharmacogn. Mag., 2007, 3(11), 177.
[63]
Ma, S.N.; Zaman Huri, H.; Yahya, F. Drug-related problems in patients with rheumatoid arthritis. Ther. Clin. Risk Manag., 2019, 15, 505-524.
[http://dx.doi.org/10.2147/TCRM.S194921] [PMID: 30962689]
[64]
Dudics, S.; Langan, D.; Meka, R.; Venkatesha, S.; Berman, B.; Che, C.T.; Moudgil, K. Natural products for the treatment of autoimmune arthritis: Their mechanisms of action, targeted delivery, and interplay with the host microbiome. Int. J. Mol. Sci., 2018, 19(9), 2508.
[http://dx.doi.org/10.3390/ijms19092508] [PMID: 30149545]
[65]
Chan, E.S.L.; Cronstein, B.N. Molecular action of methotrexate in inflammatory diseases. Arthritis Res., 2002, 4(4), 266-273.
[http://dx.doi.org/10.1186/ar419] [PMID: 12106498]
[66]
Saxena, A.K.; Singh, D.; Singh, G. Structural interaction between drug-DNA and protein-A novel approach for bioinformatics in medicine. Biomed. Res., 2009, 20(1), 28-34.
[67]
Kocaadam, B.; Şanlier, N. Curcumin, an active component of turmeric (Curcuma longa), and its effects on health. Crit. Rev. Food Sci. Nutr., 2017, 57(13), 2889-2895.
[http://dx.doi.org/10.1080/10408398.2015.1077195] [PMID: 26528921]
[68]
Zheng, Z.; Sun, Y.; Liu, Z.; Zhang, M.; Li, C.; Cai, H. The effect of curcumin and its nanoformulation on adjuvant-induced arthritis in rats. Drug Des. Devel. Ther., 2015, 9, 4931-4942.
[PMID: 26345159]
[69]
Shehzad, A.; Rehman, G.; Lee, Y.S. Curcumin in inflammatory diseases. Biofactors, 2013, 39(1), 69-77.
[http://dx.doi.org/10.1002/biof.1066] [PMID: 23281076]
[70]
Tomeh, M.; Hadianamrei, R.; Zhao, X. A review of curcumin and its derivatives as anticancer agents. Int. J. Mol. Sci., 2019, 20(5), 1033.
[http://dx.doi.org/10.3390/ijms20051033] [PMID: 30818786]
[71]
Edilova, M.I.; Akram, A.; Abdul-Sater, A.A. Innate immunity drives pathogenesis of rheumatoid arthritis. Biomed. J., 2021, , 44.(2) 172-.
[72]
Graumlich, J.F. Preventing gastrointestinal complications of NSAIDs. Postgrad. Med., 2001, 109(5), 117-128, 123-128.
[http://dx.doi.org/10.3810/pgm.2001.05.931] [PMID: 11381661]
[73]
Banji, D.; Banji, O.J.F.; Reddy, K.N.; Pinnapureddy, J.; Kumar, A.R. Evaluation of the concomitant use of methotrexate and curcumin on Freund′s complete adjuvant-induced arthritis and hematological indices in rats. Indian J. Pharmacol., 2011, 43(5), 546-550.
[http://dx.doi.org/10.4103/0253-7613.84970] [PMID: 22021998]
[74]
Coradini, K.; Friedrich, R.B.; Fonseca, F.N.; Vencato, M.S.; Andrade, D.F.; Oliveira, C.M.; Battistel, A.P.; Guterres, S.S.; da Rocha, M.I.U.M.; Pohlmann, A.R.; Beck, R.C.R. A novel approach to arthritis treatment based on resveratrol and curcumin co-encapsulated in lipid-core nanocapsules: In vivo studies. Eur. J. Pharm. Sci., 2015, 78, 163-170.
[http://dx.doi.org/10.1016/j.ejps.2015.07.012] [PMID: 26206297]
[75]
RNAE-L a, Emam, M. Therapeutic effect of crocin in collagen induced rheumatoid arthritis rat model (Crocin in Rheumatoid Arthritis). Med. J. Cairo Univ., 2017, 85(1)
[76]
Hemshekhar, M.; Sebastin Santhosh, M.; Sunitha, K.; Thushara, R.M.; Kemparaju, K.; Rangappa, K.S.; Girish, K.S. A dietary colorant crocin mitigates arthritis and associated secondary complications by modulating cartilage deteriorating enzymes, inflammatory mediators and antioxidant status. Biochimie, 2012, 94(12), 2723-2733.
[http://dx.doi.org/10.1016/j.biochi.2012.08.013] [PMID: 22939988]
[77]
Durães, F.; Pinto, M.; Sousa, E. Old drugs as new treatments for neurodegenerative diseases. Pharmaceuticals, 2018, 11(2), 44.
[http://dx.doi.org/10.3390/ph11020044] [PMID: 29751602]
[78]
McInnes, I.B.; Schett, G. The pathogenesis of rheumatoid arthritis. N. Engl. J. Med., 2011, 365(23), 2205-2219.
[http://dx.doi.org/10.1056/NEJMra1004965] [PMID: 22150039]
[79]
Lin, B.; Zhao, Y.; Han, P.; Yue, W.; Ma, X.Q.; Rahman, K.; Zheng, C.J.; Qin, L.P.; Han, T. Anti-arthritic activity of Xanthium strumarium L. extract on complete Freund׳s adjuvant induced arthritis in rats. J. Ethnopharmacol., 2014, 155(1), 248-255.
[http://dx.doi.org/10.1016/j.jep.2014.05.023] [PMID: 24862493]
[80]
Zhang, X.; Sun, J.; Xin, W.; Li, Y.; Ni, L.; Ma, X.; Zhang, D.; Zhang, D.; Zhang, T.; Du, G. Anti-inflammation effect of methyl salicylate 2-O-β-D-lactoside on adjuvant induced-arthritis rats and lipopolysaccharide (LPS)-treated murine macrophages RAW264.7 cells. Int. Immunopharmacol., 2015, 25(1), 88-95.
[http://dx.doi.org/10.1016/j.intimp.2015.01.024] [PMID: 25637446]
[81]
Zuo, J.; Xia, Y.; Li, X.; Chen, J. Therapeutic effects of dichloromethane fraction of Securidaca inappendiculata on adjuvant-induced arthritis in rat. J. Ethnopharmacol., 2014, 153(2), 352-358.
[http://dx.doi.org/10.1016/j.jep.2014.02.015] [PMID: 24583103]
[82]
Milani, A.; Basirnejad, M.; Shahbazi, S.; Bolhassani, A. Carotenoids: Biochemistry, pharmacology and treatment. Br. J. Pharmacol., 2017, 174(11), 1290-1324.
[http://dx.doi.org/10.1111/bph.13625] [PMID: 27638711]
[83]
Wang, Q.; Ye, C.; Sun, S.; Li, R.; Shi, X.; Wang, S.; Zeng, X.; Kuang, N.; Liu, Y.; Shi, Q.; Liu, R. Curcumin attenuates collagen-induced rat arthritis via anti-inflammatory and apoptotic effects. Int. Immunopharmacol., 2019, 72, 292-300.
[http://dx.doi.org/10.1016/j.intimp.2019.04.027] [PMID: 31005039]
[84]
Rinkunaite, I.; Simoliunas, E.; Alksne, M.; Dapkute, D.; Bukelskiene, V. Anti-inflammatory effect of different curcumin preparations on adjuvant-induced arthritis in rats. BMC complement. med. ther., 2021, 21(1), 1-12.
[http://dx.doi.org/10.1186/s12906-021-03207-3]
[85]
Arora, R.; Kuhad, A.; Kaur, I.P.; Chopra, K. Curcumin loaded solid lipid nanoparticles ameliorate adjuvant-induced arthritis in rats. Eur. J. Pain, 2015, 19(7), 940-952.
[http://dx.doi.org/10.1002/ejp.620] [PMID: 25400173]
[86]
Kumar, R.; Nair, V.; Gupta, Y.K.; Singh, S. Anti-inflammatory and anti-arthritic activity of aqueous extract of Rosa centifolia in experimental rat models. Int. J. Rheum. Dis., 2017, 20(9), 1072-1078.
[http://dx.doi.org/10.1111/1756-185X.12625] [PMID: 26222375]
[87]
Shapiro, S.C. Biomarkers in rheumatoid arthritis. Cureus, 2021, 13(5), e15063.
[PMID: 34141507]
[88]
Liu, H.M.; Wang, K.J. Therapeutic effect of Captopril on rheumatoid arthritis in rats. Asian Pac. J. Trop. Med., 2014, 7(12), 996-999.
[http://dx.doi.org/10.1016/S1995-7645(14)60175-9] [PMID: 25479630]
[89]
Poole, C.D.; Conway, P.; Reynolds, A.; Currie, C.J. The association between C-reactive protein and the likelihood of progression to joint replacement in people with rheumatoid arthritis: A retrospective observational study. BMC Musculoskelet. Disord., 2008, 9(1), 146.
[http://dx.doi.org/10.1186/1471-2474-9-146] [PMID: 18983663]
[90]
Goţia, S.; Popovici, I.; Hermeziu, B. Antioxidant enzymes levels in children with juvenile rheumatoid arthritis. Rev. Med. Chir. Soc. Med. Nat. Iasi, 2001, 105(3), 499-503.
[PMID: 12092181]
[91]
Mbiantcha, M.; Almas, J.; Shabana, S.U.; Nida, D.; Aisha, F. Anti-arthritic property of crude extracts of Piptadeniastrum africanum (Mimosaceae) in complete Freund’s adjuvant-induced arthritis in rats. BMC Complement. Altern. Med., 2017, 17(1), 111.
[http://dx.doi.org/10.1186/s12906-017-1623-5] [PMID: 28202019]
[92]
Xu, Q; Zhou, Y; Zhang, R; Sun, Z; Cheng, L-f Antiarthritic activity of Qi-Wu rheumatism granule (a Chinese herbal compound) on complete Freund’s adjuvant-induced arthritis in rats. Evid. Based Complement Alternat. Med., 2017, 2017, 1960517.
[http://dx.doi.org/10.1155/2017/1960517] [PMID: 29238384]
[93]
Wei, X.; Peng, M.; Liu, D.; Zhao, L.; Gu, X.; Wang, L.; Zhou, Y.; Zhao, H.; Si, N.; Wang, H.; Hou, L.; Shu, Z.; Bian, B. Integrated pharmacology reveals the mechanism of action of Bu-Shen-Tong-Du prescription against collagen-induced arthritis. Biomed. Pharmacother., 2021, 143, 112160.
[http://dx.doi.org/10.1016/j.biopha.2021.112160] [PMID: 34560546]
[94]
Xiong, H.; Ding, X.; Wang, H.; Jiang, H.; Wu, X.; Tu, C.; Wu, C.; Pi, Y.; Yang, G.; Zhao, Z.; Mei, Z. Tibetan medicine Kuan-Jin-Teng exerts anti-arthritic effects on collagen-induced arthritis rats via inhibition the production of pro-inflammatory cytokines and down-regulation of MAPK signaling pathway. Phytomedicine, 2019, 57, 271-281.
[http://dx.doi.org/10.1016/j.phymed.2018.12.023] [PMID: 30802713]
[95]
Zuo, J.; Yin, Q.; Wang, Y.W.; Li, Y.; Lu, L.M.; Xiao, Z.G.; Wang, G.D.; Luan, J.J. Inhibition of NF-κB pathway in fibroblast-like synoviocytes by α-mangostin implicated in protective effects on joints in rats suffering from adjuvant-induced arthritis. Int. Immunopharmacol., 2018, 56, 78-89.
[http://dx.doi.org/10.1016/j.intimp.2018.01.016] [PMID: 29367090]
[96]
Ogawa, M. Differentiation and proliferation of hematopoietic stem cells. Blood., 1993, 81(11), 2844-2853.
[97]
Ma, J.; Liew, C-C. Gene profiling identifies secreted protein transcripts from peripheral blood cells in coronary artery disease. J. Mol. Cell. Cardiol., 2003, 35(8), 993-998.
[http://dx.doi.org/10.1016/S0022-2828(03)00179-2] [PMID: 12878486]
[98]
Cecchi, I.; de la Rosa, A.I.; Menegatti, E.; Roccatello, D.; Collantes-Estevez, E.; Lopez-Pedrera, C.; Barbarroja, N. Neutrophils: Novel key players in rheumatoid arthritis. Current and future therapeutic targets. Autoimmun. Rev., 2018, 17(11), 1138-1149.
[http://dx.doi.org/10.1016/j.autrev.2018.06.006] [PMID: 30217550]
[99]
Hematologic abnormalities in rheumatoid arthritis. In: Seminars in arthritis and rheumatism; Mowat, A.G., Ed.; Elsevier, 1972.
[100]
Dörmer, P.; Sauer, H.; Schalhorn, A.; Wilmanns, W. Differential effect of high-dose methotrexate on erythropoiesis and granulocytopoiesis in humans. Cancer Res., 1982, 42(4), 1604-1607.
[PMID: 7060031]
[101]
Nikiphorou, E.; de Lusignan, S.; Mallen, C.; Khavandi, K.; Roberts, J.; Buckley, C.D.; Galloway, J.; Raza, K. Haematological abnormalities in new-onset rheumatoid arthritis and risk of common infections: A population-based study. Rheumatology, 2020, 59(5), 997-1005.
[http://dx.doi.org/10.1093/rheumatology/kez344] [PMID: 31501866]
[102]
Storey, M.; Jordan, S. An overview of the immune system. Nurs. Stand., 2008, 23(15), 47-56.
[http://dx.doi.org/10.7748/ns2008.12.23.15.47.c6738] [PMID: 19146032]

Rights & Permissions Print Cite
Article Metrics
39
1
Wayfinder Image
Open Access Journals Promotions
World Antimicrobial Awareness Week
© 2024 Bentham Science Publishers | Privacy Policy