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Current Medicinal Chemistry

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ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

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Research Article

The Combined Effect of Curcumin and Crocin on the Reduction of Inflammatory Responses in Arthritic Rats

Author(s): Khodabakhsh Rashidi, Mitra Korani, Houshang Nemati, Raheleh Shahraki, Shahla Korani*, Mitra Abbasifard*, Muhammed Majeed, Tannaz Jamialahmadi and Amirhossein Sahebkar*

Volume 31, Issue 28, 2024

Published on: 07 July, 2023

Page: [4562 - 4577] Pages: 16

DOI: 10.2174/0929867330666230409003744

Price: $65

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Abstract

Background: The present study evaluated the anti-arthritic impact of combined crocin and curcumin on Adjuvant Induced Arthritis (AIA) in rats.

Methods: The arthritis model was induced in rats by injecting Complete Freund’s adjuvant (CFA) into the right hind paw and was subsequently treated with crocin and curcumin. Evaluation of anti- arthritic activity was carried out using paw swelling, hematological parameters, biochemical parameters, inflammatory cytokines, and histopathology of rats.

Results: The results showed increased paw swelling, increased serum markers levels, including CRP, RF, ALP, ALT, and AST, and inflammatory cytokines (ILlβ and TNFα) along with histology changes (cartilage and bone degradation) in arthritic rats when compared to the normal group. Crocin, curcumin and crocin + curcumin administration at different doses (especially combination at 40 mg/kg and 30 mg/kg, respectively), as well as MTX, revealed a suitable therapeutic effect on AIA rats. Moreover, both phytochemicals and their combination at different doses showed effective anti- arthritic effects owing to their anti-inflammatory effects.

Conclusion: Crocin and curcumin, either alone or in combination, can be a suitable treatment modality for rheumatoid arthritis.

Keywords: Arthritis, rheumatoid, crocin, curcumin, complete freund’s adjuvant, inflammatory cytokines.

« Previous
[1]
Tastekin, N.; Aydogdu, N.; Dokmeci, D.; Usta, U.; Birtane, M.; Erbas, H.; Ture, M. Protective effects of l-carnitine and alpha-lipoic acid in rats with adjuvant arthritis. Pharmacol. Res., 2007, 56(4), 303-310.
[http://dx.doi.org/10.1016/j.phrs.2007.07.008] [PMID: 17826175]
[2]
Wang, C.; Dai, Y.; Yang, J.; Chou, G.; Wang, C.; Wang, Z. Treatment with total alkaloids from Radix Linderae reduces inflammation and joint destruction in type II collagen-induced model for rheumatoid arthritis. J. Ethnopharmacol., 2007, 111(2), 322-328.
[http://dx.doi.org/10.1016/j.jep.2006.11.031] [PMID: 17204385]
[3]
Vierboom, M.P.M.; Jonker, M.; Tak, P.P.; ’t Hart, B.A. Preclinical models of arthritic disease in non-human primates. Drug Discov. Today, 2007, 12(7-8), 327-335.
[http://dx.doi.org/10.1016/j.drudis.2007.02.012] [PMID: 17395093]
[4]
Guo, Q.; Wang, Y.; Xu, D.; Nossent, J.; Pavlos, N.J.; Xu, J. Rheumatoid arthritis: Pathological mechanisms and modern pharmacologic therapies. Bone Res., 2018, 6(1), 15.
[http://dx.doi.org/10.1038/s41413-018-0016-9] [PMID: 29736302]
[5]
Korani, S.; Korani, M.; Butler, A.E.; Sahebkar, A. Genetics and rheumatoid arthritis susceptibility in Iran. J. Cell. Physiol., 2019, 234(5), 5578-5587.
[http://dx.doi.org/10.1002/jcp.27379] [PMID: 30238988]
[6]
Zhao, J.; Arao, Y.; Sun, S.; Kikuchi, A.; Kayama, F. Oral administration of soy-derived genistin suppresses lipopolysaccharide-induced acute liver inflammation but does not induce thymic atrophy in the rat. Life Sci., 2006, 78(8), 812-819.
[http://dx.doi.org/10.1016/j.lfs.2005.05.104] [PMID: 16257011]
[7]
Smolen, J.S.; Steiner, G. Therapeutic strategies for rheumatoid arthritis. Nat. Rev. Drug Discov., 2003, 2(6), 473-488.
[http://dx.doi.org/10.1038/nrd1109] [PMID: 12776222]
[8]
Cai, X.; Zhou, H.; Wong, Y.F.; Xie, Y.; Liu, Z.Q.; Jiang, Z.H.; Bian, Z.X.; Xu, H.X.; Liu, L. Suppression of the onset and progression of collagen-induced arthritis in rats by QFGJS, a preparation from an anti-arthritic Chinese herbal formula. J. Ethnopharmacol., 2007, 110(1), 39-48.
[http://dx.doi.org/10.1016/j.jep.2006.09.008] [PMID: 17049776]
[9]
Bedoui, Y.; Guillot, X.; Sélambarom, J.; Guiraud, P.; Giry, C.; Jaffar-Bandjee, M.C.; Ralandison, S.; Gasque, P. Methotrexate an old drug with new tricks. Int. J. Mol. Sci., 2019, 20(20), 5023.
[http://dx.doi.org/10.3390/ijms20205023] [PMID: 31658782]
[10]
El-Said, K.S.; Atta, A.; Mobasher, M.A.; Germoush, M.O.; Mohamed, T.M.; Salem, M.M. Quercetin mitigates rheumatoid arthritis by inhibiting adenosine deaminase in rats. Mol. Med., 2022, 28(1), 24.
[http://dx.doi.org/10.1186/s10020-022-00432-5] [PMID: 35193490]
[11]
Feldmann, M.; Maini, R.N.; Bondeson, J.; Taylor, P.; Foxwell, B.M.J.; Brennan, F.M. Cytokine blockade in rheumatoid arthritis. Adv. Exp. Med. Biol., 2001, 490, 119-127.
[http://dx.doi.org/10.1007/978-1-4615-1243-1_13] [PMID: 11505970]
[12]
Rennie, K.L.; Hughes, J.; Lang, R.; Jebb, S.A. Nutritional management of rheumatoid arthritis: A review of the evidence. J. Hum. Nutr. Diet., 2003, 16(2), 97-109.
[http://dx.doi.org/10.1046/j.1365-277X.2003.00423.x] [PMID: 12662368]
[13]
Prasad, S.; Gupta, S.C.; Tyagi, A.K.; Aggarwal, B.B. Curcumin, a component of golden spice: From bedside to bench and back. Biotechnol. Adv., 2014, 32(6), 1053-1064.
[http://dx.doi.org/10.1016/j.biotechadv.2014.04.004] [PMID: 24793420]
[14]
Deogade, S.C.; Ghate, S. Curcumin: Therapeutic applications in systemic and oral health. Int. J. Biol. Pharm. Res., 2015, 6(4), 281-290.
[15]
Goel, A.; Kunnumakkara, A.B.; Aggarwal, B.B. Curcumin as “Curecumin”: From kitchen to clinic. Biochem. Pharmacol., 2008, 75(4), 787-809.
[http://dx.doi.org/10.1016/j.bcp.2007.08.016] [PMID: 17900536]
[16]
Jurenka, J.S. Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: A review of preclinical and clinical research. Altern. Med. Rev., 2009, 14(2), 141-153.
[PMID: 19594223]
[17]
Hasanzadeh, S., Read, M. I., Bland, A. R., Majeed, M., Jamialahmadi, T., Sahebkar, A. Curcumin: An inflammasome silencer. Pharmacological research, 2020, 159, 104921.
[http://dx.doi.org/10.1016/j.phrs.2020.104921]
[18]
Momtazi-Borojeni, A. A., Haftcheshmeh, S. M., Esmaeili, S. A., Johnston, T. P., Abdollahi, E., Sahebkar, A. Curcumin: A natural modulator of immune cells in systemic lupus erythematosus. Autoimmunity reviews, 201817(2), 125–135.
[http://dx.doi.org/10.1016/j.autrev.2017.11.016]
[19]
Mohajeri, M., Sahebkar, A. Protective effects of curcumin against doxorubicin-induced toxicity and resistance: A review. In: Critical reviews in oncology/hematology, 2018, Vol:122, pp. 30-51.
[http://dx.doi.org/10.1016/j.critrevonc.2017.12.005]
[20]
Shakeri, A.; Cicero, A.F.G.; Panahi, Y.; Mohajeri, M.; Sahebkar, A. Curcumin: A naturally occurring autophagy modulator. J. Cell. Physiol., 2019, 234(5), 5643-5654.
[http://dx.doi.org/10.1002/jcp.27404] [PMID: 30239005]
[21]
Afshari, A.R.; Jalili-Nik, M.; Abbasinezhad-Moud, F.; Javid, H.; Karimi, M.; Mollazadeh, H.; Jamialahmadi, T.; Sathyapalan, T.; Sahebkar, A. Anti-tumor effects of curcuminoids in glioblastoma multiforme: An updated literature review. Curr. Med. Chem., 2021, 28(39), 8116-8138.
[http://dx.doi.org/10.2174/1875533XMTExtNDA8x] [PMID: 33176632]
[22]
Mokhtari-Zaer, A., Marefati, N., Atkin, S. L., Butler, A. E., Sahebkar, A. The protective role of curcumin in myocardial ischemia-reperfusion injury. Journal of cellular physiology, 2018, 234(1), 214–222.
[http://dx.doi.org/10.1097/CEJ.0b013e32832c389e]
[23]
Heidari, Z.; Daei, M.; Boozari, M.; Jamialahmadi, T.; Sahebkar, A. Curcumin supplementation in pediatric patients: A systematic review of current clinical evidence. Phytother. Res., 2022, 36(4), 1442-1458.
[http://dx.doi.org/10.1002/ptr.7350] [PMID: 34904764]
[24]
Mohammed, E.; El-Beih, N.; El-Hussieny, E.; El-Ahwany, E.; Hassan, M.; Zoheiry, M. Effects of free and nanoparticulate curcumin on chemically induced liver carcinoma in an animal model. Arch. Med. Sci., 2021, 17(1), 218-227.
[http://dx.doi.org/10.5114/aoms.2020.93739] [PMID: 33488874]
[25]
Iranshahi, M.; Sahebkar, A.; Takasaki, M.; Konoshima, T.; Tokuda, H. Cancer chemopreventive activity of diversin from Ferula diversivittata in vitro and in vivo. Phytomedicine, 2010, 17 (3-4), 269-273.
[http://dx.doi.org/10.1158/0008-5472.CAN-21-1331] [PMID: 35149589]
[26]
Ganji, A., Farahani, I., Saeedifar, A. M., Mosayebi, G., Ghazavi, A., Majeed, M., Jamialahmadi, T., Sahebkar, A. Protective effects of curcumin against lipopolysaccharide-induced toxicity. Curr. Medi. Chem., 2021, 28(33), 6915–6930.
[http://dx.doi.org/10.2174/0929867328666210525124707]
[27]
Hong, J.; Bose, M.; Ju, J.; Ryu, J-H.; Chen, X.; Sang, S.; Lee, M.J.; Yang, C.S. Modulation of arachidonic acid metabolism by curcumin and related -diketone derivatives: Effects on cytosolic phospholipase A2, cyclooxygenases and 5-lipoxygenase. Carcinogenesis, 2004, 25(9), 1671-1679.
[http://dx.doi.org/10.1093/carcin/bgh165] [PMID: 15073046]
[28]
Kahkhaie, K.R.; Mirhosseini, A.; Aliabadi, A.; Mohammadi, A.; Mousavi, M.J.; Haftcheshmeh, S.M.; Sathyapalan, T.; Sahebkar, A. Curcumin: A modulator of inflammatory signaling pathways in the immune system. Inflammopharmacology, 2019, 27(5), 885-900.
[http://dx.doi.org/10.1007/s10787-019-00607-3] [PMID: 31140036]
[29]
Korani, S.; Korani, M.; Sathyapalan, T.; Sahebkar, A. Therapeutic effects of Crocin in autoimmune diseases: A review. Biofactors, 2019, 45(6), 835-843.
[http://dx.doi.org/10.1002/biof.1557] [PMID: 31430413]
[30]
Bhandari, P.R. Crocus sativus L. (saffron) for cancer chemoprevention: A mini review. J. Tradit. Complement. Med., 2015, 5(2), 81-87.
[http://dx.doi.org/10.1016/j.jtcme.2014.10.009] [PMID: 26151016]
[31]
Bolhassani, A.; Khavari, A.; Bathaie, S.Z. Saffron and natural carotenoids: Biochemical activities and anti-tumor effects. Biochim. Biophys. Acta. Rev. Cancer., 2014, 1845(1), 20-30.
[32]
Tamanoi, F.; Bathaie, S.Z. Natural products and cancer signaling: isoprenoids, polyphenols and flavonoids. Academic Press, 2014.
[33]
El-Beshbishy, H.A.; Hassan, M.H.; Aly, H.A.A.; Doghish, A.S.; Alghaithy, A.A.A. Crocin “saffron” protects against beryllium chloride toxicity in rats through diminution of oxidative stress and enhancing gene expression of antioxidant enzymes. Ecotoxicol. Environ. Saf., 2012, 83, 47-54.
[http://dx.doi.org/10.1016/j.ecoenv.2012.06.003] [PMID: 22766413]
[34]
Assimopoulou, A.N.; Sinakos, Z.; Papageorgiou, V.P. Radical scavenging activity of Crocus sativus L. extract and its bioactive constituents. Phytother. Res., 2005, 19(11), 997-1000.
[http://dx.doi.org/10.1002/ptr.1749] [PMID: 16317646]
[35]
Razavi, M.; Hosseinzadeh, H.; Abnous, K.; Motamedshariaty, V.S.; Imenshahidi, M. Crocin restores hypotensive effect of subchronic administration of diazinon in rats. Iran. J. Basic Med. Sci., 2013, 16(1), 64-72.
[PMID: 23638294]
[36]
Amin, A.; Hamza, A.A.; Daoud, S.; Khazanehdari, K.; Hrout, A.A.; Baig, B.; Chaiboonchoe, A.; Adrian, T.E.; Zaki, N.; Salehi-Ashtiani, K. Saffron-based crocin prevents early lesions of liver cancer: In vivo, in vitro and network analyses. Recent Patents Anticancer Drug Discov., 2016, 11(1), 121-133.
[http://dx.doi.org/10.2174/1574892810666151102110248] [PMID: 26522014]
[37]
Li, K.; Li, Y.; Ma, Z.; Zhao, J. Crocin exerts anti-inflammatory and anti-catabolic effects on rat intervertebral discs by suppressing the activation of JNK. Int. J. Mol. Med., 2015, 36(5), 1291-1299.
[http://dx.doi.org/10.3892/ijmm.2015.2359] [PMID: 26648423]
[38]
Zamani Taghizadeh Rabe, S.; Sahebari, M.; Mahmoudi, Z.; Hosseinzadeh, H.; Haghmorad, D.; Tabasi, N.; Rastin, M.; Khazaee, M.; Mahmoudi, M. Inhibitory effect of Crocus sativus L. ethanol extract on adjuvant-induced arthritis. Food Agric. Immunol., 2015, 26(2), 170-180.
[http://dx.doi.org/10.1080/09540105.2013.878900]
[39]
Higashino, S.; Sasaki, Y.; Giddings, J.C.; Hyodo, K.; Fujimoto Sakata, S.; Matsuda, K.; Horikawa, Y.; Yamamoto, J. Crocetin, a carotenoid from Gardenia jasminoides Ellis, protects against hypertension and cerebral thrombogenesis in stroke-prone spontaneously hypertensive rats. Phytother. Res., 2014, 28(9), 1315-1319.
[http://dx.doi.org/10.1002/ptr.5130] [PMID: 24550159]
[40]
Liu, M.; Amini, A.; Ahmad, Z. Safranal and its analogs inhibit Escherichia coli ATP synthase and cell growth. Int. J. Biol. Macromol., 2017, 95, 145-152.
[http://dx.doi.org/10.1016/j.ijbiomac.2016.11.038] [PMID: 27865956]
[41]
Eslami, M.; Bayat, M.; Mozaffari Nejad, A.S.; Sabokbar, A.; Anvar, A.A. Effect of polymer/nanosilver composite packaging on long-term microbiological status of Iranian saffron (Crocus sativus L.). Saudi J. Biol. Sci., 2016, 23(3), 341-347.
[http://dx.doi.org/10.1016/j.sjbs.2015.07.004] [PMID: 27081358]
[42]
Christodoulou, E.; Kadoglou, N.P.E.; Stasinopoulou, M.; Konstandi, O.A.; Kenoutis, C.; Kakazanis, Z.I.; Rizakou, A.; Kostomitsopoulos, N.; Valsami, G. Crocus sativus L. aqueous extract reduces atherogenesis, increases atherosclerotic plaque stability and improves glucose control in diabetic atherosclerotic animals. Atherosclerosis, 2018, 268, 207-214.
[http://dx.doi.org/10.1016/j.atherosclerosis.2017.10.032] [PMID: 29128090]
[43]
Sadeghnia, H.R.; Shaterzadeh, H.; Forouzanfar, F.; Hosseinzadeh, H. Neuroprotective effect of safranal, an active ingredient of Crocus sativus, in a rat model of transient cerebral ischemia. Folia Neuropathol., 2017, 3(3), 206-213.
[http://dx.doi.org/10.5114/fn.2017.70485] [PMID: 28984113]
[44]
Samarghandian, S.; Samini, F.; Azimi-Nezhad, M.; Farkhondeh, T. Anti-oxidative effects of safranal on immobilization-induced oxidative damage in rat brain. Neurosci. Lett., 2017, 659, 26-32.
[http://dx.doi.org/10.1016/j.neulet.2017.08.065] [PMID: 28866053]
[45]
Konstantopoulos, P.; Doulamis, I.; Tzani, A.; Korou, M.L.; Agapitos, E.; Vlachos, I.; Pergialiotis, V.; Verikokos, C.; Mastorakos, G.; Katsilambros, N.; Perrea, D. Metabolic effects of Crocus sativus and protective action against non-alcoholic fatty liver disease in diabetic rats. Biomed. Rep., 2017, 6(5), 513-518.
[http://dx.doi.org/10.3892/br.2017.884] [PMID: 28529733]
[46]
Mashmoul, M.; Azlan, A.; Mohtarrudin, N.; Mohd Yusof, B.N.; Khaza’ai, H.; Khoo, H.E.; Farzadnia, M.; Boroushaki, M.T. Protective effects of saffron extract and crocin supplementation on fatty liver tissue of high-fat diet-induced obese rats. BMC Complement. Altern. Med., 2016, 16(1), 401.
[http://dx.doi.org/10.1186/s12906-016-1381-9] [PMID: 27770798]
[47]
Nader, M.; Chahine, N.; Salem, C.; Chahine, R. Saffron (Crocus sativus) pretreatment confers cardioprotection against ischemia-reperfusion injuries in isolated rabbit heart. J. Physiol. Biochem., 2016, 72(4), 711-719.
[http://dx.doi.org/10.1007/s13105-016-0510-8] [PMID: 27507116]
[48]
Ebadi, M. Pharmacodynamic basis of herbal medicine; CRC press, 2006.
[http://dx.doi.org/10.1201/9781420006452]
[49]
Yaribeygi, H.; Mohammadi, M.T.; Rezaee, R.; Sahebkar, A. Crocin improves renal function by declining Nox-4, IL-18, and p53 expression levels in an experimental model of diabetic nephropathy. J. Cell. Biochem., 2018, 119(7), 6080-6093.
[http://dx.doi.org/10.1002/jcb.26806] [PMID: 29575259]
[50]
Yaribeygi, H.; Mohammadi, M.T.; Sahebkar, A. Crocin potentiates antioxidant defense system and improves oxidative damage in liver tissue in diabetic rats. Biomed. Pharmacother., 2018, 98, 333-337.
[http://dx.doi.org/10.1016/j.biopha.2017.12.077] [PMID: 29274590]
[51]
Zhao, X.; Kim, Y.R.; Min, Y.; Zhao, Y.; Do, K.; Son, Y.O. Natural plant extracts and compounds for rheumatoid arthritis therapy. Medicina, 2021, 57(3), 266.
[http://dx.doi.org/10.3390/medicina57030266] [PMID: 33803959]
[52]
Qi, Y.; Li, S.; Pi, Z.; Song, F.; Lin, N.; Liu, S.; Liu, Z. Metabonomic study of Wu-tou decoction in adjuvant-induced arthritis rat using ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 2014, 953-954, 11-19.
[http://dx.doi.org/10.1016/j.jchromb.2014.01.044] [PMID: 24561351]
[53]
Lü, S.; Wang, Q.; Li, G.; Sun, S.; Guo, Y.; Kuang, H. The treatment of rheumatoid arthritis using Chinese medicinal plants: From pharmacology to potential molecular mechanisms. J. Ethnopharmacol., 2015, 176, 177-206.
[http://dx.doi.org/10.1016/j.jep.2015.10.010] [PMID: 26471289]
[54]
Guo, Q.; Zheng, K.; Fan, D.; Zhao, Y.; Li, L.; Bian, Y.; Qiu, X.; Liu, X.; Zhang, G.; Ma, C.; He, X.; Lu, A. Wu-Tou decoction in rheumatoid arthritis: Integrating network pharmacology and in vivo pharmacological evaluation. Front. Pharmacol., 2017, 8, 230.
[http://dx.doi.org/10.3389/fphar.2017.00230] [PMID: 28515692]
[55]
Yu, T.; Qing, M.; Xiao, W. Study of the regulatory effect of Guizhi-Shaoyao-Zhimu decoction on RA synovial cell apoptosis. Cont Med., 2010, 16, 18-20.
[56]
Liu, W.; Sun, Y.; Cheng, Z.; Guo, Y.; Liu, P.; Wen, Y. Crocin exerts anti-inflammatory and anti-arthritic effects on type II collagen-induced arthritis in rats. Pharm. Biol., 2018, 56(1), 209-216.
[http://dx.doi.org/10.1080/13880209.2018.1448874] [PMID: 29540097]
[57]
Borashan, F.A.; Ilkhanipoor, M.; Hashemi, M.; Farrokhi, F. Investigation the effects of curcumin on serum hepatic enzymes activity in a rheumatoid arthritis model. Electron. J. Biotechnol., 2009, 4(4), 129-133.
[58]
Banji, D.; Pinnapureddy, J.; Banji, O.J.F.; Saidulu, A.; Hayath, M.S. Synergistic activity of curcumin with methotrexate in ameliorating Freund’s complete adjuvant induced arthritis with reduced hepatotoxicity in experimental animals. Eur. J. Pharmacol., 2011, 668(1-2), 293-298.
[http://dx.doi.org/10.1016/j.ejphar.2011.06.006] [PMID: 21693118]
[59]
Nair, V.; Singh, S.; Gupta, Y.K. Evaluation of disease modifying activity of Coriandrum sativum in experimental models. Indian J. Med. Res., 2012, 135(2), 240-245.
[PMID: 22446868]
[60]
Doig, K.; Zhang, B. A methodical approach to interpreting the red blood cell parameters of the complete blood count. Clin. Lab. Sci., 2017, 30(3), 173-185.
[http://dx.doi.org/10.29074/ascls.30.3.173]
[61]
Mehta, A.; Sethiya, N.K.; Mehta, C.; Shah, G.B. Anti–arthritis activity of roots of Hemidesmus indicus R.Br. (Anantmul) in rats. Asian Pac. J. Trop. Med., 2012, 5(2), 130-135.
[http://dx.doi.org/10.1016/S1995-7645(12)60011-X] [PMID: 22221757]
[62]
Patil, K.S.; Suryavanshi, J. Effect of Celastrus paniculatus Willd. seed on adjuvant induced arthritis in rats. Pharmacogn. Mag., 2007, 3(11), 177.
[63]
Ma, S.N.; Zaman Huri, H.; Yahya, F. Drug-related problems in patients with rheumatoid arthritis. Ther. Clin. Risk Manag., 2019, 15, 505-524.
[http://dx.doi.org/10.2147/TCRM.S194921] [PMID: 30962689]
[64]
Dudics, S.; Langan, D.; Meka, R.; Venkatesha, S.; Berman, B.; Che, C.T.; Moudgil, K. Natural products for the treatment of autoimmune arthritis: Their mechanisms of action, targeted delivery, and interplay with the host microbiome. Int. J. Mol. Sci., 2018, 19(9), 2508.
[http://dx.doi.org/10.3390/ijms19092508] [PMID: 30149545]
[65]
Chan, E.S.L.; Cronstein, B.N. Molecular action of methotrexate in inflammatory diseases. Arthritis Res., 2002, 4(4), 266-273.
[http://dx.doi.org/10.1186/ar419] [PMID: 12106498]
[66]
Saxena, A.K.; Singh, D.; Singh, G. Structural interaction between drug-DNA and protein-A novel approach for bioinformatics in medicine. Biomed. Res., 2009, 20(1), 28-34.
[67]
Kocaadam, B.; Şanlier, N. Curcumin, an active component of turmeric (Curcuma longa), and its effects on health. Crit. Rev. Food Sci. Nutr., 2017, 57(13), 2889-2895.
[http://dx.doi.org/10.1080/10408398.2015.1077195] [PMID: 26528921]
[68]
Zheng, Z.; Sun, Y.; Liu, Z.; Zhang, M.; Li, C.; Cai, H. The effect of curcumin and its nanoformulation on adjuvant-induced arthritis in rats. Drug Des. Devel. Ther., 2015, 9, 4931-4942.
[PMID: 26345159]
[69]
Shehzad, A.; Rehman, G.; Lee, Y.S. Curcumin in inflammatory diseases. Biofactors, 2013, 39(1), 69-77.
[http://dx.doi.org/10.1002/biof.1066] [PMID: 23281076]
[70]
Tomeh, M.; Hadianamrei, R.; Zhao, X. A review of curcumin and its derivatives as anticancer agents. Int. J. Mol. Sci., 2019, 20(5), 1033.
[http://dx.doi.org/10.3390/ijms20051033] [PMID: 30818786]
[71]
Edilova, M.I.; Akram, A.; Abdul-Sater, A.A. Innate immunity drives pathogenesis of rheumatoid arthritis. Biomed. J., 2021, , 44.(2) 172-.
[72]
Graumlich, J.F. Preventing gastrointestinal complications of NSAIDs. Postgrad. Med., 2001, 109(5), 117-128, 123-128.
[http://dx.doi.org/10.3810/pgm.2001.05.931] [PMID: 11381661]
[73]
Banji, D.; Banji, O.J.F.; Reddy, K.N.; Pinnapureddy, J.; Kumar, A.R. Evaluation of the concomitant use of methotrexate and curcumin on Freund′s complete adjuvant-induced arthritis and hematological indices in rats. Indian J. Pharmacol., 2011, 43(5), 546-550.
[http://dx.doi.org/10.4103/0253-7613.84970] [PMID: 22021998]
[74]
Coradini, K.; Friedrich, R.B.; Fonseca, F.N.; Vencato, M.S.; Andrade, D.F.; Oliveira, C.M.; Battistel, A.P.; Guterres, S.S.; da Rocha, M.I.U.M.; Pohlmann, A.R.; Beck, R.C.R. A novel approach to arthritis treatment based on resveratrol and curcumin co-encapsulated in lipid-core nanocapsules: In vivo studies. Eur. J. Pharm. Sci., 2015, 78, 163-170.
[http://dx.doi.org/10.1016/j.ejps.2015.07.012] [PMID: 26206297]
[75]
RNAE-L a, Emam, M. Therapeutic effect of crocin in collagen induced rheumatoid arthritis rat model (Crocin in Rheumatoid Arthritis). Med. J. Cairo Univ., 2017, 85(1)
[76]
Hemshekhar, M.; Sebastin Santhosh, M.; Sunitha, K.; Thushara, R.M.; Kemparaju, K.; Rangappa, K.S.; Girish, K.S. A dietary colorant crocin mitigates arthritis and associated secondary complications by modulating cartilage deteriorating enzymes, inflammatory mediators and antioxidant status. Biochimie, 2012, 94(12), 2723-2733.
[http://dx.doi.org/10.1016/j.biochi.2012.08.013] [PMID: 22939988]
[77]
Durães, F.; Pinto, M.; Sousa, E. Old drugs as new treatments for neurodegenerative diseases. Pharmaceuticals, 2018, 11(2), 44.
[http://dx.doi.org/10.3390/ph11020044] [PMID: 29751602]
[78]
McInnes, I.B.; Schett, G. The pathogenesis of rheumatoid arthritis. N. Engl. J. Med., 2011, 365(23), 2205-2219.
[http://dx.doi.org/10.1056/NEJMra1004965] [PMID: 22150039]
[79]
Lin, B.; Zhao, Y.; Han, P.; Yue, W.; Ma, X.Q.; Rahman, K.; Zheng, C.J.; Qin, L.P.; Han, T. Anti-arthritic activity of Xanthium strumarium L. extract on complete Freund׳s adjuvant induced arthritis in rats. J. Ethnopharmacol., 2014, 155(1), 248-255.
[http://dx.doi.org/10.1016/j.jep.2014.05.023] [PMID: 24862493]
[80]
Zhang, X.; Sun, J.; Xin, W.; Li, Y.; Ni, L.; Ma, X.; Zhang, D.; Zhang, D.; Zhang, T.; Du, G. Anti-inflammation effect of methyl salicylate 2-O-β-D-lactoside on adjuvant induced-arthritis rats and lipopolysaccharide (LPS)-treated murine macrophages RAW264.7 cells. Int. Immunopharmacol., 2015, 25(1), 88-95.
[http://dx.doi.org/10.1016/j.intimp.2015.01.024] [PMID: 25637446]
[81]
Zuo, J.; Xia, Y.; Li, X.; Chen, J. Therapeutic effects of dichloromethane fraction of Securidaca inappendiculata on adjuvant-induced arthritis in rat. J. Ethnopharmacol., 2014, 153(2), 352-358.
[http://dx.doi.org/10.1016/j.jep.2014.02.015] [PMID: 24583103]
[82]
Milani, A.; Basirnejad, M.; Shahbazi, S.; Bolhassani, A. Carotenoids: Biochemistry, pharmacology and treatment. Br. J. Pharmacol., 2017, 174(11), 1290-1324.
[http://dx.doi.org/10.1111/bph.13625] [PMID: 27638711]
[83]
Wang, Q.; Ye, C.; Sun, S.; Li, R.; Shi, X.; Wang, S.; Zeng, X.; Kuang, N.; Liu, Y.; Shi, Q.; Liu, R. Curcumin attenuates collagen-induced rat arthritis via anti-inflammatory and apoptotic effects. Int. Immunopharmacol., 2019, 72, 292-300.
[http://dx.doi.org/10.1016/j.intimp.2019.04.027] [PMID: 31005039]
[84]
Rinkunaite, I.; Simoliunas, E.; Alksne, M.; Dapkute, D.; Bukelskiene, V. Anti-inflammatory effect of different curcumin preparations on adjuvant-induced arthritis in rats. BMC complement. med. ther., 2021, 21(1), 1-12.
[http://dx.doi.org/10.1186/s12906-021-03207-3]
[85]
Arora, R.; Kuhad, A.; Kaur, I.P.; Chopra, K. Curcumin loaded solid lipid nanoparticles ameliorate adjuvant-induced arthritis in rats. Eur. J. Pain, 2015, 19(7), 940-952.
[http://dx.doi.org/10.1002/ejp.620] [PMID: 25400173]
[86]
Kumar, R.; Nair, V.; Gupta, Y.K.; Singh, S. Anti-inflammatory and anti-arthritic activity of aqueous extract of Rosa centifolia in experimental rat models. Int. J. Rheum. Dis., 2017, 20(9), 1072-1078.
[http://dx.doi.org/10.1111/1756-185X.12625] [PMID: 26222375]
[87]
Shapiro, S.C. Biomarkers in rheumatoid arthritis. Cureus, 2021, 13(5), e15063.
[PMID: 34141507]
[88]
Liu, H.M.; Wang, K.J. Therapeutic effect of Captopril on rheumatoid arthritis in rats. Asian Pac. J. Trop. Med., 2014, 7(12), 996-999.
[http://dx.doi.org/10.1016/S1995-7645(14)60175-9] [PMID: 25479630]
[89]
Poole, C.D.; Conway, P.; Reynolds, A.; Currie, C.J. The association between C-reactive protein and the likelihood of progression to joint replacement in people with rheumatoid arthritis: A retrospective observational study. BMC Musculoskelet. Disord., 2008, 9(1), 146.
[http://dx.doi.org/10.1186/1471-2474-9-146] [PMID: 18983663]
[90]
Goţia, S.; Popovici, I.; Hermeziu, B. Antioxidant enzymes levels in children with juvenile rheumatoid arthritis. Rev. Med. Chir. Soc. Med. Nat. Iasi, 2001, 105(3), 499-503.
[PMID: 12092181]
[91]
Mbiantcha, M.; Almas, J.; Shabana, S.U.; Nida, D.; Aisha, F. Anti-arthritic property of crude extracts of Piptadeniastrum africanum (Mimosaceae) in complete Freund’s adjuvant-induced arthritis in rats. BMC Complement. Altern. Med., 2017, 17(1), 111.
[http://dx.doi.org/10.1186/s12906-017-1623-5] [PMID: 28202019]
[92]
Xu, Q; Zhou, Y; Zhang, R; Sun, Z; Cheng, L-f Antiarthritic activity of Qi-Wu rheumatism granule (a Chinese herbal compound) on complete Freund’s adjuvant-induced arthritis in rats. Evid. Based Complement Alternat. Med., 2017, 2017, 1960517.
[http://dx.doi.org/10.1155/2017/1960517] [PMID: 29238384]
[93]
Wei, X.; Peng, M.; Liu, D.; Zhao, L.; Gu, X.; Wang, L.; Zhou, Y.; Zhao, H.; Si, N.; Wang, H.; Hou, L.; Shu, Z.; Bian, B. Integrated pharmacology reveals the mechanism of action of Bu-Shen-Tong-Du prescription against collagen-induced arthritis. Biomed. Pharmacother., 2021, 143, 112160.
[http://dx.doi.org/10.1016/j.biopha.2021.112160] [PMID: 34560546]
[94]
Xiong, H.; Ding, X.; Wang, H.; Jiang, H.; Wu, X.; Tu, C.; Wu, C.; Pi, Y.; Yang, G.; Zhao, Z.; Mei, Z. Tibetan medicine Kuan-Jin-Teng exerts anti-arthritic effects on collagen-induced arthritis rats via inhibition the production of pro-inflammatory cytokines and down-regulation of MAPK signaling pathway. Phytomedicine, 2019, 57, 271-281.
[http://dx.doi.org/10.1016/j.phymed.2018.12.023] [PMID: 30802713]
[95]
Zuo, J.; Yin, Q.; Wang, Y.W.; Li, Y.; Lu, L.M.; Xiao, Z.G.; Wang, G.D.; Luan, J.J. Inhibition of NF-κB pathway in fibroblast-like synoviocytes by α-mangostin implicated in protective effects on joints in rats suffering from adjuvant-induced arthritis. Int. Immunopharmacol., 2018, 56, 78-89.
[http://dx.doi.org/10.1016/j.intimp.2018.01.016] [PMID: 29367090]
[96]
Ogawa, M. Differentiation and proliferation of hematopoietic stem cells. Blood., 1993, 81(11), 2844-2853.
[97]
Ma, J.; Liew, C-C. Gene profiling identifies secreted protein transcripts from peripheral blood cells in coronary artery disease. J. Mol. Cell. Cardiol., 2003, 35(8), 993-998.
[http://dx.doi.org/10.1016/S0022-2828(03)00179-2] [PMID: 12878486]
[98]
Cecchi, I.; de la Rosa, A.I.; Menegatti, E.; Roccatello, D.; Collantes-Estevez, E.; Lopez-Pedrera, C.; Barbarroja, N. Neutrophils: Novel key players in rheumatoid arthritis. Current and future therapeutic targets. Autoimmun. Rev., 2018, 17(11), 1138-1149.
[http://dx.doi.org/10.1016/j.autrev.2018.06.006] [PMID: 30217550]
[99]
Hematologic abnormalities in rheumatoid arthritis. In: Seminars in arthritis and rheumatism; Mowat, A.G., Ed.; Elsevier, 1972.
[100]
Dörmer, P.; Sauer, H.; Schalhorn, A.; Wilmanns, W. Differential effect of high-dose methotrexate on erythropoiesis and granulocytopoiesis in humans. Cancer Res., 1982, 42(4), 1604-1607.
[PMID: 7060031]
[101]
Nikiphorou, E.; de Lusignan, S.; Mallen, C.; Khavandi, K.; Roberts, J.; Buckley, C.D.; Galloway, J.; Raza, K. Haematological abnormalities in new-onset rheumatoid arthritis and risk of common infections: A population-based study. Rheumatology, 2020, 59(5), 997-1005.
[http://dx.doi.org/10.1093/rheumatology/kez344] [PMID: 31501866]
[102]
Storey, M.; Jordan, S. An overview of the immune system. Nurs. Stand., 2008, 23(15), 47-56.
[http://dx.doi.org/10.7748/ns2008.12.23.15.47.c6738] [PMID: 19146032]

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