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Review Article

以PIWI蛋白和PiRNA失调为生物标志物的妇科癌症诊断和治疗的新视角

卷 31, 期 4, 2024

发表于: 24 March, 2023

页: [453 - 463] 页: 11

弟呕挨: 10.2174/0929867330666230214101837

价格: $65

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摘要

术语“妇科癌症”用于女性生殖系统中发生的一组癌症。其中一些癌症在发达国家和发展中国家被列为主要死亡原因。缺乏适当的诊断策略是使它们致命的最重要原因之一。PIWI相互作用RNA或piRNA是一类小的非编码RNA，含有24-32个核苷酸。这些RNA参与一些细胞机制，它们在各种癌症中的作用被累积的证据证实。在本综述中，我们收集了一些关于这些RNA和PIWI蛋白家族成员的作用的信息，为准确的诊断生物标志物和更有效的抗癌药物提供了新的见解，副作用更少。

关键词: PIWI蛋白，piRNA，PIWIL2，卵巢癌，宫颈癌，抗癌药物。

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