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Current Medicinal Chemistry

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ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

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Review Article

Labelling Matrix Metalloproteinases

Author(s): Run-Fu Zhang, Bing Zhang, Wang Chang-Jiang* and Jing-Yi Jin*

Volume 30, Issue 40, 2023

Published on: 24 February, 2023

Page: [4569 - 4585] Pages: 17

DOI: 10.2174/0929867330666230113121728

Price: $65

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Abstract

Matrix metalloproteinases (MMPs) are a family of zinc-containing proteases that participate in many physiological and pathological processes in vivo. Recently, the MMP network has been established according to a deeper understanding of its functions. Some MMPs have been also regarded as biomarkers of various diseases, including inflammation, nerve diseases, and cancers. MMP labelling has been thus paid more attention in recent decades. Accordingly, both reagents and technologies for MMP labelling have been rapidly developed. Here we summarize the recent development of some MMP labelling methods. This review was identified through keyword (MMPs; labelling; etc.) searches in the ScienceDirect database, Scifinder, Web of Science, and PubMed for which typical cases were used for an inductive overview. In spite of the advances in MMP labelling, selective labelling of a specific MMP is still an open issue. We hope that this article can be helpful in developing specific MMP labelling methods in future.

Keywords: Matrix metalloproteinase, biological targeting, protein labelling, radioactive labelling, fluorescent probe, zinc-containing proteases.

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