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Infectious Disorders - Drug Targets

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Review Article

Latest in COVID-19 Vaccine 'Candidates' Race

Author(s): Manar Fayiz Atoum*, Dalia Abu Zreig and Laith Majed Abu Zreig

Volume 23, Issue 1, 2023

Published on: 31 August, 2022

Article ID: e180822207640 Pages: 10

DOI: 10.2174/1871526522666220818124416

Price: $65

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Abstract

Restoring everyday civil life from the devastating pandemic of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) can be only by the development of an efficient vaccine. As of April 12, 2022, 497,960,492 confirmed cases of COVID-19 were reported, including 6,181,850 lives having been lost worldwide and completely paralyzing the d global economy. Detection of a novel coronavirus SARS-CoV-2 in Wuhan, in December 2019, and the genetic sequence of SARS-CoV-2 that was published on January 11, 2020, leads to a global race, to prepare for a preventive vaccine. No single institution can develop a vaccine individually because there are many stages for developing and producing a successful vaccine. Since this virus threatens the health, the economy, and society the demand for a fast-track vaccine is understandable. This article tries to give an overview of vaccine 'candidates' development and clinical trials, and it mentions some challenges of using these vaccines for managing SARS‐CoV‐2.

Keywords: COVID-19 vaccine, mRNA-based vaccines, inactivated virus, replication-deficient adenovirus vector, SARSCoV- 2, fast-track vaccine.

Graphical Abstract

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