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Review Article

分子伴侣介导的自噬：代谢疾病的潜在靶标

卷 30, 期 16, 2023

发表于: 04 October, 2022

页: [1887 - 1899] 页: 13

弟呕挨: 10.2174/0929867329666220811141955

价格: $65

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摘要

自噬是细胞选择性去除受损细胞器或蛋白质的过程。分子伴侣介导的自噬（CMA）是一种降解细胞中含有KFERQ五肽的蛋白质的自噬。CMA可以降解受损或过量的蛋白质，因此在维持细胞内蛋白质平衡方面发挥着重要作用。CMA还可以通过降解生命活动中的关键蛋白质（如脂质和葡萄糖代谢）发挥调节作用。本文介绍了CMA过程，并描述了当前常用的CMA检测方法。此外，我们还描述了CMA在糖和脂质代谢中的作用。最后，我们总结了CMA在糖尿病肾病（DN）、酒精性肝病（ALD）和非酒精性脂肪性肝病（NAFLD）等代谢性疾病中的作用，并讨论了CMA作为代谢性疾病潜在治疗靶点的作用。

关键词: 分子伴侣介导的自噬（CMA）、代谢性疾病、自噬、糖尿病肾病（DN）、LAMP2A、HSC70。

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