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Infectious Disorders - Drug Targets

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ISSN (Print): 1871-5265
ISSN (Online): 2212-3989

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Divulging Incipient SARS-CoV-2 Delta (B.1.617.2) Variant: Possible Interference with Global Scenario

Author(s): Suman Kumar Ray and Sukhes Mukherjee*

Volume 23, Issue 1, 2023

Published on: 10 August, 2022

Article ID: e060622205636 Pages: 4

DOI: 10.2174/1871526522666220606092243

Price: $65

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Abstract

SARS-CoV-2 Delta variant, also known as lineage B.1.617.2, is a variant of lineage B.1.617 of SARS-CoV-2, the virus that causes COVID-19. The B.1.617.2 variant was first discovered in India in December 2020, and by mid-April 2021, it had become the most often reported variant. On May 31, 2021, the World Health Organization (WHO) designated it as the Delta variation. Delta is 40-60% more transmissible than Alpha and nearly twice as transmissible as the original Wuhan strain of SARSCoV- 2, according to data. According to some evidence, the Delta variation may cause more severe illness in unprotected people than prior variants. A rapid increase in instances of this variation has been observed in the United Kingdom, which has been linked to travel from India and community transmission. WHO reports that the Delta version of COVID-19 has already been found in different countries throughout the world. According to the available information, the Delta variant appears to increase transmissibility, secondary attack rate, hospitalization risk, and immune escape. Due to the lack of data, the possible effects of the Delta variation on vaccination and treatment effectiveness remain unknown. However, neutralization efficiency in vaccinated people and resistance to monoclonal antibody therapy of the Delta variant have been documented in recent investigations.

Keywords: SARS-CoV-2 Delta variant, B.1.617.2, vaccine, vaccination efficacy, patent, neutralization.

Graphical Abstract

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