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Current Molecular Medicine

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ISSN (Print): 1566-5240
ISSN (Online): 1875-5666

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Review Article

Diagnostic, Prognostic, and Therapeutic Value of miR-148b in Human Cancers

Author(s): Afsane Bahrami * and Gordon A. Ferns

Volume 22, Issue 10, 2022

Published on: 12 January, 2022

Page: [860 - 869] Pages: 10

DOI: 10.2174/1566524021666211213123315

Price: $65

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Abstract

MicroRNAs (miRs) is a class of conserved, small, noncoding RNA molecules that modulate gene expression post-transcriptionally. miR-148b is a member of miR- 148/152 family generally known to be a tumor suppressor via its effect on different signaling pathways and regulatory genes. Aberrant expression of miR-148b has recently been shown to be responsible for tumorigenesis of several different cancer types. This review discusses the current evidence regarding the involvement of miR-148b expression in human cancers and its potential clinical importance for tumor diagnosis, prognosis, and therapeutics.

Keywords: miR-148/152, KIT, Cyclin D1, ALCAM, WNT, cancer.

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