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Review Article

细胞外囊泡作为评估免疫抑制药物不良反应的创新工具

卷 29, 期 20, 2022

发表于: 20 January, 2022

页: [3586 - 3600] 页: 15

弟呕挨: 10.2174/0929867328666211208114022

价格: $65

Open Access Journals Promotions 2
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摘要

背景：细胞外囊泡(EVs)是由供体细胞释放并被受体细胞吸收的异质性小囊泡家族，是在生理和病理条件中具有重要作用的重要介质。EVs存在于多种生物液体中，具有很大的诊断和预后价值。它们因其极端的多功能性而引起了科学界的兴趣。事实上，它们允许我们假设新的治疗策略，因为它们除了作为细胞信号介质外，还作为生物标志物、药物载体和潜在的新治疗药物发挥着重要的作用。它们还参与免疫调节，有能力将对药物的耐药性从一个细胞传递到一个更敏感的细胞，并可以作为药物传递系统。 目的：介绍EVs与免疫抑制药物之间的主要相互作用。 结果：已知EVs与免疫抑制药物的相互作用，特别是环孢素、糖皮质激素、雷帕霉素、甲氨蝶呤、环磷酰胺、埃库利珠单抗、英夫利昔单抗、塞妥珠单抗、依那西普、醋酸格拉拉默和芬格利莫德。 结论：本文综述提供了EVs与免疫抑制药物之间联系的相关信息，重点介绍了EVs作为评估免疫抑制剂作用的工具，提示了其创新的特性和新的可能的治疗用途。

关键词: 细胞外囊泡，免疫抑制剂，生物标志物，治疗疗效，不良反应，治疗个性化。

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