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Review Article

射血分数保留性心力衰竭病理生理机制研究进展

卷 23, 期 1, 2023

发表于: 18 February, 2022

页: [54 - 62] 页: 9

弟呕挨: 10.2174/1566524021666211129111202

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摘要

心衰（HF）是一种严重的临床综合征，通常发生在各种心血管疾病的晚期，具有高死亡率和再住院率的特点。根据左心室（LV）射血分数（LVEF），HF被分为EF降低的HF（HFrEF；LVEF<40%），EF中等的HF（HFmrEF；LVEF 40-49%），以及EF保留的HF（HFpEF；LVEF≥50%）。HFpEF约占心衰病例的50%，并已成为心衰的主要形式。HFpEF的死亡率与HFrEF相似。现在还没有明确的治疗方案可以降低HFpEF的发病率和死亡率。了解基本的病理机制对于开发新的有效的HFpEF治疗方案至关重要。近年来，对HFpEF的病理生理机制的研究已经取得了重大进展。本综述旨在更新HFpEF的病理生理学机制的研究进展。

关键词: 心力衰竭、舒张功能障碍、炎症和氧化应激、内皮功能障碍、心脏变时性功能不全、心脏储备功能障碍、肺动脉高压。

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