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Current Pharmaceutical Biotechnology

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ISSN (Print): 1389-2010
ISSN (Online): 1873-4316

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Review Article

Anti-inflammatory Effects of Mesenchymal Stem Cells and their Secretomes in Pneumonia

Author(s): Kamal Hezam, Rigen Mo, Chen Wang, Yue Liu and Zongjin Li*

Volume 23, Issue 9, 2022

Published on: 07 September, 2021

Page: [1153 - 1167] Pages: 15

DOI: 10.2174/1389201022666210907115126

Price: $65

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Abstract

Mesenchymal stem cells (MSCs) are multipotent progenitor cells that play crucial roles in the microenvironment of injured tissues. The potential therapeutics of MSCs have attracted extensive attention for several diseases such as acute respiratory distress syndrome (ARDS) and novel coronavirus disease 2019 (COVID-19) pneumonia. MSC-extracellular vesicles have been isolated from MSC-conditioned media (MSC-CM) with similar functional effects as parent MSCs. The therapeutic role of MSCs can be achieved through the balance between the inflammatory and regenerative microenvironments. Clinical settings of MSCs and their extracellular vesicles remain promising for many diseases, such as ARDS and pneumonia. However, their clinical applications remain limited due to the cost of growing and storage facilities of MSCs with a lack of standardized MSC-CM. This review highlights the proposed role of MSCs in pulmonary diseases and discusses the recent advances of MSC application for pneumonia and other lung disorders.

Keywords: Pneumonia, mesenchymal stem cells (MSCs), inflammation, extracellular vesicles (EVs), acute respiratory distress syndrome (ARDS), COVID-19.

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Graphical Abstract

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